3,937 results match your criteria: "Cochin University of Science & Technology[Affiliation]"

Article Synopsis
  • * A study examined 131 female patients with X-linked dominant incontinentia pigmenti (IP), finding that 36% produced autoantibodies against IFN-α and/or IFN-ω, significantly higher than age-matched controls.
  • * The presence of these autoantibodies is linked to an abnormally small thymus and predisposes patients to life-threatening viral infections, while those without these autoantibodies do not face the same risk.
View Article and Find Full Text PDF

IL-7-dependent and -independent lineages of IL-7R-dependent human T cells.

J Clin Invest

October 2024

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.

Article Synopsis
  • Some babies with a specific mutation in the IL7R gene have a serious immune problem called SCID, where they lack a certain type of immune cells called T cells, but still have normal B and NK cells.
  • In a study of 6 adults who have a similar genetic issue, they showed low levels of T cells but had relatively normal levels of other immune cells, indicating a more specific problem in T cell development.
  • Even though their T cells didn’t grow well in the lab, the study hints that there might be another way T cells can develop that doesn’t depend solely on the IL-7 cytokine.
View Article and Find Full Text PDF

Kuttanad is a unique wetland agriculture system featuring polder-based rice cultivation below sea level. Facing increasing pollution threats from agrochemicals, this FAO-recognized Globally Important Agricultural Heritage System (GIAHS) needs constant monitoring and risk assessment. The present study investigated the seasonal dynamics of agricultural pesticide residues in fish cultured in the wetland system.

View Article and Find Full Text PDF

Occurrence, virulence, and AMR profile of isolated from shellfish growing areas located along the south-west coast of India.

J Water Health

September 2024

Department of Marine Biology, Microbiology and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Lakeside Campus, Cochin 682 016, India E-mail:

is a leading cause of human gastroenteritis associated with seafood consumption. The present study aimed to investigate the occurrence and risk assessment of isolated from live Indian black clams, sediment, and water samples collected from shellfish harvesting areas located along the south-west coast of India. Out of the total 72 samples collected, 55.

View Article and Find Full Text PDF

We use a 16-month-long, 20 Hz wind data from a mooring deployed in the Bay of Bengal (BoB) to study the characteristics of turbulent wind stress ( events in the marine atmospheric boundary layer (MABL). Quadrant analysis of the motion-corrected and suggests that sweep and ejections, representing downward stress transfer into the ocean, dominate the (~ 140%). In comparison, outward and inward interactions representing an upward stress transfer into the atmosphere provide the counter-contribution (~ 40%).

View Article and Find Full Text PDF

Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.

Clin Microbiol Infect

December 2024

OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:

Article Synopsis
  • Hospital-acquired bloodstream infections (HA-BSI) in ICU patients can be life-threatening, and this study aimed to see how early adequate antibiotic treatment affects 28-day mortality rates for patients who survive at least one day after infection onset.
  • Using data from a multicenter study with 2,418 patients, researchers found that those who received adequate treatment within 24 hours had a lower 28-day mortality rate (32.8%) compared to those who were inadequately treated (40%).
  • The study concluded that inadequate antibiotic therapy within 24 hours contributes significantly to 28-day mortality, indicating that quicker treatment could greatly improve patient outcomes in cases of HA-BSI.
View Article and Find Full Text PDF

Effects of Losartan on Patients Hospitalized for Acute COVID-19: A Randomized Controlled Trial.

Clin Infect Dis

September 2024

Division of Critical Care Medicine, and Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, Canada.

Article Synopsis
  • Researchers investigated the effect of losartan, an angiotensin receptor blocker, on 28-day mortality in hospitalized COVID-19 patients compared to usual care, due to its potential impact on angiotensin levels.
  • The study was stopped early due to safety concerns, showing that adverse events and hypotension were significantly higher in the losartan group (39.8% SAEs and 30.4% hypotension) versus the control group (27.2% SAEs and 15.3% hypotension).
  • There was no significant difference in 28-day mortality (6.5% for losartan vs. 5.9% for usual care), indicating that ARBs should be used cautiously in this patient population to
View Article and Find Full Text PDF

Background: PET-Magnetic Resonance (PET-MR) imaging is an upcoming investigative modality with a few installations in Asia and only three in India. PET-Computed Tomography (PET-CT) is an established diagnostic cornerstone for oncological indications but with limited resolution for small lesions due to low soft-tissue contrast and additional radiation exposure.

Objective: Our primary objective was to evaluate the diagnostic performance of simultaneous PET-MR and PET-CT in lesion detection in oncological practice.

View Article and Find Full Text PDF

The cultivation of tilapias, the third most farmed fish group globally, has been rapidly growing, especially in Southeast Asia. This surge in tilapia farming intensification has led to increased use of antibiotics to control bacterial diseases. This study investigated the safety implications of administering graded doses of enrofloxacin (ENF) at 0 (control), 10, 30, 50 and 100 mg/kg biomass/day orally to .

View Article and Find Full Text PDF

Purpose: To evaluate biopsy-related complications and detection rates of any PCa and clinically significant PCa (csPCa, intended as grade group ≥ 2) between MRI-targeted TP fusion biopsies (TPBx) and TR ones (TRBx).

Methods: We performed a multicentric study on 4841 patients who underwent fusion biopsy between 2016 and 2023. A case-control matching was performed to find comparable cohorts of 646 TPBx and 646 TRBx.

View Article and Find Full Text PDF

River discharge into the sea and its implications on the environmental setting and fauna in the nearshore represent the intricate interactions among the atmosphere, hydrosphere, lithosphere, and biosphere. This study, based on in-situ and satellite data, presents how spatially varying river discharge laden with suspended sediments structure the hydrography and the nearshore benthic environment over a 590 km southwest (Kerala) coast of India. The 41 rivers that discharge along the Kerala coast are monsoon-driven; they are small but swift and cumulatively supply huge amounts of freshwater and suspended sediments into the Southeastern Arabian Sea (SEAS) during the Southwest Monsoon (SWM) when around 70 % (1925 mm) of the yearly rainfall occurs.

View Article and Find Full Text PDF
Article Synopsis
  • - Patient-reported outcome measures (PROMs) are tools that help assess a patient's health at a specific time and are important for personalized healthcare.
  • - The paper reviews the use of visual analog scales (VAS) for measuring asthma and allergic rhinitis control, particularly focusing on the MASK-air app, which includes electronic VAS forms.
  • - A randomized controlled trial was conducted to validate the electronic VAS, and further evaluations confirmed the effectiveness of VAS questions and additional medication scores for allergic asthma symptoms.
View Article and Find Full Text PDF

This study focuses on the distribution of some selected organochlorine pesticides and emerging contaminants within the surface sediments of an Arctic fjord, Kongsfjorden and nearby lakes. Organochlorine pesticides (OCPs) such as dicloran, p,p'-DDT, p,p'-DDE, p,p'-DDD were studied along with five emerging contaminants namely diuron, chlorpyrifos, dicofol, pendimethalin and bifenthrin. The highest values of OCPs recorded among the fjord and lake environments during the time of study was 0.

View Article and Find Full Text PDF

This paper proposes the design of a metasurface for polarization and incident angle-insensitive RCS reduction applications. An ellipse-shaped unit cell is utilized as a polarization converter, which is then arranged to form a checkerboard surface. While a single layer checkerboard structure gives a wideband RCS reduction, a double layer structure yields polarization and incident angle independent operation.

View Article and Find Full Text PDF

Genomic insights into symbiosis and host adaptation of sponge-associated novel bacterium, Rossellomorea orangium sp. nov.

FEMS Microbiol Lett

January 2024

Department of Marine Biology, Microbiology and Biochemistry, Lake Side Campus, Cochin University of Science and Technology, Fine Arts Avenue, Pallimukku, Kochi, Ernakulam 682016, Kerala, India.

Sponge-associated microorganisms play vital roles in marine sponge ecology. This study presents a genomic investigation of Rossellomorea sp. MCCB 382, isolated from Stelletta sp.

View Article and Find Full Text PDF

The 16th Network of Young Researchers in Andrology meeting, hosted at the Sleepwell Hostel in Brussels, Belgium, was the first Network of Young Researchers in Andrology meeting as the young arm of the European Academy of Andrology. Over three days, this vibrant event provided a valuable platform for early-career researchers in andrology to present and discuss their research. With 41 attendees from 12 different countries, the meeting featured a diverse scientific program including keynote lectures from six world-leading experts, covering a broad range of topics in andrology.

View Article and Find Full Text PDF

Prolonged exposure of human dermal fibroblasts (HDF) to ultraviolet (UV) radiation triggers the production of reactive oxygen species by upregulating the expression of matrix metalloproteinases (MMPs), causing type-I collagen degradation and photoaging. A sulfated (1 → 3)/(1 → 4) mannogalactan exopolysaccharide (BVP-2) characterized as [→3)-α-Galp-{(1 → 4)-α-6-O-SO-Manp}-(1 → 3)-α-6-O-SO-Galp-(1→] was isolated from seaweed-associated heterotrophic bacterium Bacillus velezensis MTCC13097. Whole genome analysis of B.

View Article and Find Full Text PDF

In India, Ceramic Water Filters (CWF) named G-filters are becoming a point-of-use household water treatment solution. The filter's reliability may be primarily characterized by the filtrate turbidity and microbial removal efficiency. The temperature and moisture gradients of the location affect its performance.

View Article and Find Full Text PDF

Fish skin-derived gelatin has garnered significant attention recently due to its abundant availability and promising bioactive properties. This comprehensive review elucidates various intricacies concerning fish skin-derived gelatin peptides, including their preparation techniques, bioactive profiles, underlying mechanisms, and methods for stability enhancement. The review investigates diverse extraction methods and processing approaches for acquiring gelatin peptides from fish skin, emphasizing their impact on the peptide composition and functional characteristics.

View Article and Find Full Text PDF
Article Synopsis
  • Photobiomodulation (PBM) is a new technique using light to potentially slow down early and intermediate dry age-related macular degeneration (dAMD) and is being analyzed for its safety and effectiveness with the EYE-LIGHT device.
  • The study involved patients over 50 with dAMD, randomly assigned to either PBM treatment or a sham procedure, with assessments conducted after four weeks.
  • Results showed that PBM treatment was generally well-tolerated, with improved visual acuity for some patients, though no significant differences in central subfield thickness were observed.
View Article and Find Full Text PDF

Assessing anticancer properties of PEGylated platinum nanoparticles on human breast cancer cell lines usingassays.

Biomed Phys Eng Express

September 2024

Department of Physics and Electronics, Christ University, Bengaluru, Karnataka- 560029, India.

This study describes the in-vitro cytotoxic effects of PEG-400 (Polyethylene glycol-400)-capped platinum nanoparticles (PEGylated Pt NPs) on both normal and cancer cell lines. Structural characterization was carried out using x-ray diffraction and Raman spectroscopy with an average crystallite size 5.7 nm, and morphological assessment using Scanning electron microscopy (SEM) revealed the presence of spherical platinum nanoparticles.

View Article and Find Full Text PDF

While most individuals suffer progressive disease following HIV infection, a small fraction spontaneously controls the infection. Although CD8 T-cells have been implicated in this natural control, their mechanistic roles are yet to be established. Here, we combined mathematical modeling and analysis of previously published data from 16 SIV-infected macaques, of which 12 were natural controllers, to elucidate the role of CD8 T-cells in natural control.

View Article and Find Full Text PDF

The Fracture Phenotypes in Women and Men of 50 Years and Older with a Recent Clinical Fracture.

Curr Osteoporos Rep

December 2024

Department of Rheumatology, Amsterdam UMC, Amsterdam, the Netherlands.

Purpose Of Review: We review the literature about patients 50 years and older with a recent clinical fracture for the presence of skeletal and extra-skeletal risks, their perspectives of imminent subsequent fracture, falls, mortality, and other risks, and on the role of the fracture liaison service (FLS) for timely secondary fracture prevention.

Recent Findings: Patients with a recent clinical fracture present with heterogeneous patterns of bone-, fall-, and comorbidity-related risks. Short-term perspectives include bone loss, increased risk of fractures, falls, and mortality, and a decrease in physical performance and quality of life.

View Article and Find Full Text PDF

Genetic modifiers and ascertainment drive variable expressivity of complex disorders.

medRxiv

August 2024

Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.

Article Synopsis
  • - The study examines how secondary genetic variants can influence the clinical features of individuals with primary disease-causing variants, suggesting that these modifiers play a significant role in disease expression.
  • - Specifically focusing on the 16p12.1 deletion, researchers identified various rare and common variants that predisposed individuals to specific developmental issues, such as neurological defects and microcephaly.
  • - By analyzing data from different cohorts, the findings indicate that the effects of primary and secondary variants on phenotype vary depending on the specific primary variant involved, highlighting the need for personalized approaches in treatment.
View Article and Find Full Text PDF

Socioeconomic Deprivation Weighs Heavily on Liver Fibrosis and Mortality After Hepatitis C Cure (ANRS CO22 Hepather).

J Viral Hepat

December 2024

Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, Marseille, France.

Although Hepatitis C virus (HCV) infection can be cured with direct-acting antivirals (DAA), some cured patients face a serious risk of advanced liver damage and early mortality. In order to avoid these two negative health outcomes, it is important to identify and assess related risk factors. Little is currently known about socioeconomic and behavioural factors in this context.

View Article and Find Full Text PDF