104 results match your criteria: "Clubbing of the Nails"
[Nail Clubbing].
Rev Med Suisse
October 2024
Service de médecine interne et des soins intensifs, Hôpital de Nyon, Groupement hospitalier de l'Ouest lausannois, 1260 Nyon.
Article Synopsis
- A 78-year-old male with COPD (GOLD 3E) is hospitalized due to a COPD exacerbation and exhibits unusual finger and nail abnormalities, indicating nail clubbing.
- The hyponychial angle is measured at 195 degrees, and a positive Schamroth sign is present, suggesting a potential underlying issue.
- Further investigation reveals significant weight loss and a CT scan that identifies a peri-hilar mass, ultimately diagnosing small cell lung cancer through biopsy.
Digital clubbing in cystic fibrosis: The nails as clues to advanced disease.
J Am Acad Dermatol
November 2024
Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address:
Response to Hill et al, "Digital clubbing in cystic fibrosis: The nails as clues to advanced disease".
J Am Acad Dermatol
November 2024
Department of Dermatology, University of Virginia, Charlottesville, Virginia.
Homozygous Missense Variant in the Solute Carrier Organic Anion Transporter 2A1 () Gene Underlies Isolated Nail Clubbing.
Genes (Basel)
February 2023
Department of Biochemistry, Women University Swabi, Swabi 23430, Khyber Pakhtunkhwa (KPK), Pakistan.
Article Synopsis
- - The study focuses on a rare genetic condition called inherited isolated nail clubbing, characterized by enlarged finger and toe terminal segments and thickened nails, linked to mutations in specific genes.
- - Researchers examined an extended Pakistani family with two affected siblings from an unaffected consanguineous union to better understand the genetic and clinical aspects of this condition.
- - A novel genetic variant was identified, which may disrupt normal protein function, providing new insights into the genetic basis of nail development and the underlying causes of isolated congenital nail clubbing.
Ellis-Van Creveld Syndrome: A Rare Case Report of an Indian Child With Rare Cardiac Anomalies and Normal Intelligence.
Cureus
October 2022
Department of Cardiology, CARE Hospital, Hyderabad, IND.
Article Synopsis
- Ellis-Van Creveld syndrome (EVCS) is a genetic disorder caused by abnormalities in a gene on chromosome 4, leading to specific skeletal and cardiovascular defects.
- Symptoms of EVCS include short stature, short limbs, polydactyly (extra fingers/toes), malformed nails, dental issues, and congenital heart defects.
- The case report describes a 4.5-year-old girl exhibiting symptoms like a cough, cyanosis, rapid heart and breathing rates, along with signs of facial swelling and clubbing, highlighting a rare manifestation of EVCS.
Nail involvement in autosomal recessive congenital ichthyosis.
Clin Dermatol
October 2022
Department of Dermatology, Research Unit Genodermatosis and Cancers LR12SP03, Habib Thameur Hospital, University of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Article Synopsis
- - The study focuses on autosomal recessive congenital ichthyosis (ARCI), a type of nonsyndromic ichthyosis, and particularly examines the frequently overlooked nail changes associated with the condition, which had limited documentation in existing literature.
- - Researchers conducted a clinical and dermatoscopic examination of 25 ARCI patients aged 1 to 43 years at a Tunisian hospital over a six-month period, finding that 72% exhibited changes in multiple nails, with common issues including periungual hyperkeratosis and xanthonychia.
- - The findings revealed that adults had a significantly higher frequency of nail changes compared to children, establishing associations between certain nail abnormalities and ARCI, while also creating the first comprehensive
Soft Tissue Chondroma: A Possible Diagnosis of Single-Digit Nail Clubbing.
Dermatol Surg
January 2022
Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
Article Synopsis
- Supplemental digital content enhances the main text by providing additional resources and information.
- This content may include videos, charts, or interactive elements that aid understanding.
- Accessing this supplemental material can deepen your grasp of the subject matter discussed in the main text.
Digital Clubbing in Hereditary Hemorrhagic Telangiectasia/Juvenile Polyposis Syndrome.
Acta Dermatovenerol Croat
April 2021
Anna Mrzljak MD, PhD, Department of Gastroenterology and Hepatology, University Hospital Center Zagreb, Kišpatićeva 12, Zagreb; School of Medicine, University of Zagreb, , Salata 3b, 10000 Zagreb, Croatia;
Article Synopsis
- * The condition can coexist with juvenile polyposis syndrome (JPS), complicating treatment and increasing health risks, but often only leads to mild physical symptoms like digital clubbing.
- * A case study of a 15-year-old girl highlighted her diagnosis of HHT and JPS, revealing challenges such as recurrent gastrointestinal bleeding and the absence of typical skin findings (telangiectasias) usually seen in HHT patients.
Nails in systemic disease.
Clin Med (Lond)
May 2021
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK
Article Synopsis
- - Changes in the color, size, shape, or texture of nails can signal systemic diseases and are important for diagnosis! - Understanding these nail changes helps healthcare professionals manage general medical patients more effectively! - The article reviews both common and rare nail changes linked to various systemic health issues!
Unilateral Nail Clubbing in a Hemiparetic Patient.
Cutis
February 2021
Department of Dermatology, Cleveland Clinic Foundation, Ohio.
Cutaneous Paraneoplastic Syndromes with Nail Involvement.
Dermatol Clin
April 2021
Nail Disease Centre, Rue des Serbes 42, Cannes 06400, France.
Article Synopsis
- Cutaneous paraneoplastic syndromes are rare skin conditions that are not cancerous themselves but are related to the presence of a tumor.
- These skin and nail changes occur due to substances produced by the tumor or as a reaction to it, and they often improve when the underlying cancer is treated.
- The article aims to help with the early identification of these skin signs, which can lead to quicker cancer diagnosis and better patient outcomes.
Nail is Systemic Disorders: Main Signs and Clues.
Dermatol Clin
April 2021
Saint-Pierre, Brugmann and Queen Fabiola Children University Hospitals, Université Libre de Bruxelles, Belgium. Electronic address:
Article Synopsis
- This article offers a brief overview of common nail symptoms and signs associated with various systemic disorders, useful for dermatology consultations.
- It summarizes the information found in specialized textbooks, making it more accessible for readers.
- Each section includes capsule summaries to highlight key points about nail signs related to specific health issues.
Chronic Enteropathy Associated with SLCO2A1 with Pachydermoperiostosis.
Intern Med
April 2021
Department of General Internal Medicine, Saitama Medical University, Japan.
A 49-year-old man complained of chronic palpitation and shortness of breath, which had recently become exacerbated. A blood examination indicated severe refractory anemia and hypoproteinemia. Physical examinations revealed anemia, a systolic murmur, and spoon nails.
View Article and Find Full Text PDFOccult Non-small Cell Lung Cancer Presenting as Paraneoplastic Gastroparesis: A Case Report and Literature Review.
Cureus
March 2019
Gastroenterology and Hepatology, John H. Stroger Jr. Hospital of Cook County, Chicago, USA.
Article Synopsis
- A case study is presented of a 61-year-old man who experienced severe gastroparesis, which is a rare condition often linked to underlying cancer, specifically poorly differentiated non-small cell lung cancer in this instance.
- Initial symptoms included significant nausea, vomiting, bloating, and a substantial weight loss, while various tests yielded normal results until imaging revealed a lung nodule associated with cancer.
- Treatment involved chemotherapy, abdominal symptom management, dietary changes, and psychological support, leading to gradual clinical improvement in the patient's condition.
Congenital methaemoglobinaemia diagnosed in an adolescent boy.
BMJ Case Rep
March 2019
Cardiology, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Article Synopsis
- * Medical exams showed consistent central cyanosis and low oxygen saturation while cardiovascular and respiratory systems appeared normal; previous diagnoses of pulmonary arteriovenous fistulae were ruled out with further tests.
- * The tests revealed unusually high levels of methaemoglobin in the blood, confirming a diagnosis of methaemoglobinaemia, and the family was informed about its hereditary nature.
Nail clubbing in laxative abuse: case report and review of the literature.
J Eat Disord
March 2019
3Department of Renal medicine, Gosford Hospital, Gosford, Australia.
Article Synopsis
- * A specific case of a young woman with clubbing related to laxative abuse is presented, along with a review of similar instances in the literature.
- * The conclusion emphasizes the need to consider laxative abuse when assessing clubbing in individuals prone to eating disorders, to avoid unnecessary medical investigations and better address the underlying eating disorder.
[A boy with digital clubbing].
Ned Tijdschr Geneeskd
December 2018
Maastricht Universitair Medisch Centrum+, afd. Kindergeneeskunde, Maastricht.
Article Synopsis
- A 4-year-old boy was referred for medical evaluation due to symptoms including pan-digital clubbing and watch-glass nails.
- Other significant findings included a history of surgical closure of a patent arterial duct, reduced knee mobility, and the fact that his parents are consanguineous (related by blood).
- These symptoms and family background suggest a diagnosis of primary hypertrophic osteoarthropathy (PHO), which was confirmed by identifying a homozygous mutation in the 15-hydroxyprostaglandine dehydrogenase gene.
Pachydermoperiostosis: The value of molecular diagnosis.
Ann Dermatol Venereol
December 2017
Department of Dermatology, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France; MAGEC, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France. Electronic address:
Article Synopsis
- Pachydermoperiostosis is a rare genetic disorder linked to mutations in two genes, HPGD and SLCO2A1, leading to symptoms like thickened skin and bone changes.
- Two cases illustrate the disorder: a 7-year-old girl with HPGD mutation and a 41-year-old man with SLCO2A1 mutation, each presenting distinct symptoms and complications.
- Genotype-phenotype correlations indicate that SLCO2A1 mutation patients may have more severe symptoms and complications, suggesting the need for molecular diagnosis and hematologic follow-up.
[Anomalous Systemic Arterialization of a Normal Basal Lung Segment with Aneurysm of the Aberrant Artery].
Kyobu Geka
November 2016
Department of Surgery, Oita Prefectural Hospital, Oita, Japan.
Article Synopsis
- A 40-year-old woman undergoing smoking cessation was found to have clubbing of the nails and an aneurysm in an aberrant artery associated with her left lung, which was linked to anomalous systemic arterialization.
- The aberrant artery measured 13 mm in diameter and developed an aneurysm of 17 mm, leading to surgical intervention involving ligation and lobectomy by a cardiovascular surgeon.
- Pathological examination revealed severe atherosclerosis in the aberrant artery, emphasizing the need for careful treatment strategies when dealing with such conditions, especially in cases with aneurysms.
Homozygous SLCO2A1 translation initiation codon mutation in a Pakistani family with recessive isolated congenital nail clubbing.
Br J Dermatol
August 2017
Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, CO, 80045, U.S.A.
[Chronic kidney disease associated with Poems syndrome: Report of one case].
Rev Med Chil
April 2016
POEMS syndrome is characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes. We report a woman with the syndrome, who had peripheral polyneuropathy, osteosclerotic myeloma, monoclonal IgA elevation, hypothyroidism, hypogonadotrophic hypogonadism, hyperprolactinemia, adrenal insufficiency, hepatosplenomegaly, lymphadenopathy, thyroid and parotid enlargement, Castlemans disease, papilledema, stiff and hyperpigmented skin, white nails, clubbing, ascites and chronic diarrhea. She had also a nephropathy characterized by microscopic hematuria, proteinuria, renal insufficiency and a unilateral kidney retraction.
View Article and Find Full Text PDF[Tranverse acro-osteolysis: A rare cause of nail dystrophy].
Ann Dermatol Venereol
April 2016
Service de dermatologie, hôpital Saint-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France. Electronic address:
Article Synopsis
- * A 48-year-old woman exhibited a nail lesion and pseudo-clubbing in her right index finger; X-rays showed transverse osteolysis in the distal phalanx, while other clinical exams were normal.
- * The case emphasizes the unique characteristics of transverse AO and its potential links to various causes, noting the significance of nail involvement in diagnosis, marking it as the first documented instance of transverse AO in a single finger linked to brachyonychia without a known cause.
Nail Deformities and Injuries.
Prim Care
December 2015
Department of Family and Community Medicine, Penn State Milton S. Hershey Medical Center, 500 University Avenue, Hershey, PA 17033, USA. Electronic address:
Article Synopsis
- - Nail deformities are common in primary care and can indicate underlying disorders that may go unnoticed unless properly inspected during routine visits.
- - Many nail issues, like onychomycosis (fungal infection), paronychia (infection around the nail), and ingrown toenails, can be treated effectively by primary care providers.
- - More serious conditions, such as early pterygium (abnormal skin growth) or clubbing (curved nails), require a detailed evaluation and may need referral to a specialist for further assessment.