Development of a novel nomogram for the prediction of surgical site infection risk after loop ileostomy closure.

Background: A postoperative surgical site infection (SSI) is a prevalent complication after loop ileostomy closure. There are few studies on the risk factors and the development of predictive models for postoperative SSIs. The aim of this study was to develop and validate a nomogram model capable of accurately predicting the occurrence of postoperative SSIs.

Through-the-scope tack application for defect closure following endoscopic submucosal dissection.

Effective closure of both muscular and mucosal defects after endoscopic submucosal dissection (ESD) remains a technical challenge. Failure to adequately address such defects may increase the risk of delayed perforation. In this video case report, we demonstrate the application of the through-the-scope (TTS) tack system for defect closure following ESD in a patient with a cecal lesion.

Overcoming drug delivery challenges with lipid-based nanofibers for enhanced wound repair.

Wound healing is a dynamic, multi-phase process that includes haemostasis, tissue regeneration, cellular proliferation, and matrix modification. Traditional wound care procedures frequently encounter complications such as delayed healing and infection, demanding new therapeutic approaches. In this context, nanomaterial-based devices provide considerable benefits due to their capacity to improve medication delivery and tissue healing.

Management of Lumbar Abscess Secondary to Colocutaneous Fistula From Complicated Diverticular Disease Using Negative Pressure Therapy.

Diverticular disease is a common gastrointestinal condition with rising prevalence. Complications, such as fistulas, are rare but significant, often requiring innovative treatment strategies. This case report examines the use of negative pressure wound therapy (NPWT) with instillation (VERAFLO®, KCI, an Acelity Company, San Antonio, Texas) and antiseptic solution (VASHE®, Urgo Medical North America LLC, Fort Worth, Texas) in treating a colocutaneous fistula secondary to complicated diverticular disease.

Endoscopy-assisted vitrectomy for severe ocular penetrating trauma with corneal opacity.

Aim: To assess the utility and efficiency of endoscopy-assisted vitrectomy (EAV) for the treatment of corneal opacity in severe ocular trauma.

Methods: Patients who underwent fundus examination using a preoperative slit lamp and intraoperative endoscopy, followed by EAV and additional surgery were retrospectively recruited. Silicone oil removal and penetrating keratoplasty were used in selected eyes at postoperative follow-ups.

Analysis of systemic serum vancomycin levels following intraarticular application in primary total joint arthroplasty.

Introduction: Periprosthetic joint infection (PJI) is a serious complication following primary total joint arthroplasty (TJA). PJI accounts for 15-25% of revision surgeries, therefore it is associated with PJI is associated with substantial patient morbidity and mortality as well as increased healthcare expenditures due to complex treatment strategies. Recently, intraoperative local application of vancomycin powder is increasingly being used in primary total hip and knee arthroplasty (THA, TKA) as an additive strategy for PJI prevention.

Successful Investigational Phage Therapy for Pan-Resistant Bacterial Mediastinitis Following Type II Hybrid Aortic Arch Replacement.

A 47-year-old woman presented to our hospital with Stanford type B aortic dissection with retrograde arch extension. The decision was made to undergo hybrid arch repair with thoracic endovascular aortic repair. The patient underwent surgery, but her intraoperative course was complicated by delayed sternal closure and mediastinitis requiring flap reconstruction.

Endoscopic Suturing of Skull Base Dura and its Effectiveness in Preventing CSF Leak.

Proper skull base repair is essential in preventing postoperative cerebrospinal fluid (CSF) leak following endonasal endoscopic skull base surgery. Direct suturing of the skull base dura is desirable but difficult. Here, we discuss the effectiveness of endoscopic suturing of skull base dura in cases of skull base lesions with intraoperative CSF leak.

Surgical Explantation of an Amplatzer Device for Patent Foramen Ovale Closure in a Patient With Nickel Allergy: A Case Report.

Patent foramen ovale (PFO) closure using percutaneous devices, such as the Amplatzer occluder, is a common treatment for patients with a history of cryptogenic stroke or transient ischemic attack (TIA). Although generally well-tolerated, some patients may develop adverse reactions to the device materials, particularly in the presence of a nickel allergy. Symptoms can include chest pain, rashes, and migraines, which may necessitate surgical removal of the device.

Wound Healing Complications After Sternotomy-Causes, Prevention, and Treatment-A New Look at an Old Problem.

Median sternotomy is one of the most common procedures in cardiac surgery. This corresponds to the relatively high frequency of infections where surgical incisions are performed. In the prevention of healing disorders, the medical staff intervention is important, as is the patient.

The Impact of EndoVAC in Addressing Post-Esophagectomy Anastomotic Leak in Esophageal Cancer Management.

Anastomotic leakage (AL) remains a major complication after esophagectomy, especially in patients with esophagogastric cancers who have undergone neoadjuvant therapies, which can impair tissue healing. Endoscopic vacuum-assisted closure (EndoVAC) is an innovative approach aimed at managing AL by facilitating wound drainage, reducing infection, and promoting granulation tissue formation, thus supporting effective healing. This review explores the role and effectiveness of EndoVAC in treating AL post-esophagectomy in esophageal cancer patients.

Tissue adhesive for wound closure, as adjunct to staples, reduces postoperative wound drainage after total knee arthroplasty.

Background: Wound drainage after total knee or hip arthroplasty is a relatively frequent complication. It results in delayed mobilization, prolonged hospital stay, increased costs and is associated with an increased risk of infection. In this study, tissue adhesive was administered as an adjunct to skin closure with staples.

Silver nanoparticles loaded with pomegranate peel extract and hyaluronic acid mediate recovery of cutaneous wounds infected with .

Smart innovative nanocomposites based on active ingredients and metallic nanoparticles with effective wound healing and antifungal properties are efficient in overcoming the limitations of traditional therapeutic products. Open wounds provide an ideal niche for colonization by () which poses substantial global health issues owing to delayed wound healing and disordered healing mechanisms. Therefore, proficient innovative therapies that control infection and promote wound healing are of imperative importance for the management of wounds and prevention of infection and possible complications.

Efficacy and safety of applying oxidized regenerated cellulose sheets to the parietal pleura of open chest wounds in thoracic surgery: a prospective randomized controlled trial protocol.

Background: According to a large-scale clinical trial in Japan, segmentectomy for small peripheral non-small cell lung cancer has an advantage over lobectomy in terms of overall survival, while it could also increase the incidence of local recurrence. In ipsilateral reoperations, intrathoracic adhesions from a previous surgery increase the risk of lung injury and bleeding, which may result in intraoperative and postoperative complications. The ability of oxidized regenerated cellulose (ORC) sheets to prevent postoperative adhesions has been demonstrated in the abdomen, and the same effect is expected in the thoracic region.

Surgical Site Allergic Contact Dermatitis to 2-Octyl-Cyanoacrylate: A Systematic Review and FDA MAUDE Review.

Background: Skin adhesives containing 2-ocyl cyanoacrylate are a common source of allergic contact dermatitis (ACD) that complicate postoperative wound healing. There are limited studies that describe postoperative cutaneous reactions to skin adhesives and clinical management.

Objectives: To review the incidence, description, and clinical management of surgical site ACD to 2-ocyl cyanoacrylate.

Efficacy of Cold Atmospheric Plasma in Chronic Diabetic Foot Ulcer Management: A Case Report.

BACKGROUND Diabetes mellitus is a significant global health issue, affecting millions and costing billions annually in management. A major complication of diabetes is foot ulcers, which heal slowly due to nerve damage (neuropathy) and poor circulation. These ulcers have a high risk of infection and, if untreated, can lead to amputation.

Phosphocreatine-mediated enhancement of mitochondrial function for accelerated healing of diabetic foot ulcers through the PGC-1α-NRF-1 signaling pathway.

Diabetic foot ulcers (DFUs) pose a significant clinical challenge due to their slow healing and high risk of complications, which severely affect patient quality of life. Central to the delayed healing observed in DFUs is mitochondrial dysfunction, a critical factor impairing cellular repair processes. Phosphocreatine (PCr), a vital molecule involved in cellular energy buffering and ATP regeneration, has recently emerged as a promising therapeutic candidate for ameliorating mitochondrial dysfunction and enhancing tissue repair.

Short-Term Outcomes Following Operative Repair of the Burst Abdomen: A Retrospective Review of Different Techniques.

Introduction: Abdominal wall closure in postoperative burst abdomen remains challenging. Different techniques vary between definitive closure and temporary closure. The aim of this study was to examine the short-term outcomes for different closure techniques.

Closure of the osteocutaneous fibula flap donor site with a tonearm (propeller) flap: Anatomic considerations and surgical indications.

Background: Skin graft is frequently used for donor site closure after osteocutaneous fibula free flap (OCFFF) harvest when primary closure is not possible. Partial skin graft loss requiring wound care is a common complication. The purposes of this prospective study were to investigate the perforator anatomy for local propeller or tonearm flap closure and compare the outcomes to those of skin graft closure.

Reconstruction Using a Bilobed Flap in a Patient With Recurrent Neck Soft Tissue Metastasis From Oral Cancer: A Case Report.

Soft tissue defects in the head and neck are frequently encountered, often resulting from trauma or the surgical management of malignancies. Flap reconstruction plays a critical role in the closure of these defects, aiming to minimize complications and improve cosmetic outcomes. While various flap techniques are commonly utilized in head and neck reconstruction, to the best of our knowledge, the bilobed flap has not been previously reported in this anatomical region.

Case Report: Abdominal Wall Abscess as First Clinical Sign of Jejunal Perforation After Blunt Abdominal Trauma.

Aim: To discuss extended retrorectal abscess secondary to blunt abdominal trauma as a cause of abdominal wall (AW) infection and impairment.

Methods: According to the CARE checklist, we describe a rare case of blunt abdominal trauma with late diagnosis of jejunal perforation with an abscess that extensively dissected the retromuscular space.

Results: A 65 years-old female patient experienced multiple traumas after a traffic collision.

Pediatric endoscopic pilonidal sinus treatment: lessons learned after 100 consecutive cases.

Aim: Pediatric endoscopic pilonidal sinus treatment (PEPSiT) has favorable short-term-outcomes, but there is a lack of reliable data on medium and long-term follow-up. The objective of our study was to evaluate the effectiveness and advantages of PEPSiT versus conventional surgery of pilonidal sinus in the pediatric population.

Methods: A quasi-experimental study was carried out in pediatric patients undergoing pilonidal sinus surgery at a single institution from 2019 to 2022.

Novel Use of an Aseptically Processed Amnion-Chorion Placental Allograft to Complement Wound Closure in High-Risk Sternotomy Patients: Clinical Safety and Outcomes.

Objectives Wound dehiscence is defined as the partial or complete separation of the layers of a surgical wound. Wound dehiscence and infections are of significant concern in the field of surgery as they can lead to a range of complications, including infection, delayed healing, increased healthcare costs, and patient discomfort. For patients at high risk of sternal wound dehiscence and infection, optimization of wound closure is critical.