1,424 results match your criteria: "Clostridial Gas Gangrene"
A Critical Review of Postbiotics as Promising Novel Therapeutic Agents for Clostridial Infections.
Probiotics Antimicrob Proteins
November 2024
Applied Microbiology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Clostridial infections, known for their severity and rapid progression, present significant challenges in both clinical and veterinary fields. These bacteria, which can survive without oxygen and produce protective spores, cause many diseases, ranging from simple gastrointestinal disorders to severe and potentially fatal infections including botulism, tetanus, and gas gangrene. The rising occurrence of antibiotic-resistant strains and the repetitive character of some Clostridial illnesses, including Clostridioides difficile infections (CDI), highlight the immediate need for alternate treatment approaches.
View Article and Find Full Text PDFClostridium Septicum: Cause of Gas Gangrene in the Upper Extremity Leading to Proximal Trans-Humeral Amputation, A Review of Clostridium septicum.
J Orthop Case Rep
November 2024
Department of Orthopaedic Surgery, Philadelphia Hand Surgeon PLLC, Lankenau Medical Center, Wynnewood, Pennsylvania.
Introduction: Gas gangrene is a rare, often lethal infection of soft tissue that is commonly associated with the Clostridial species due to penetrating injuries. Case reports of spontaneous atraumatic gas gangrene due to the Clostridium septicum species are exceedingly rare. Atraumatic C.
View Article and Find Full Text PDFA reverse vaccinomics approach for the designing of novel immunogenic multi-epitope vaccine construct against gas gangrene and related colorectal cancer for Clostridium septicum DSM 7534.
Hum Immunol
November 2024
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan. Electronic address:
Purpose: Costridium septicum, the causative agent of clostridial myonecrosis or gas gangrene, has been linked with colorectal malignancies, particularly tumors of the ascending colon. Due to the pathogen's resistance and the limited understanding of its genomic structure, effective therapeutic strategies are needed. This study focuses on developing a vaccine to address this issue.
View Article and Find Full Text PDFLarge Clostridial Toxins: A Brief Review and Insights into Antigen Design for Veterinary Vaccine Development.
Mol Biotechnol
October 2024
Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas - Campus Universitário, Capão do Leão, Rio Grande Do Sul, CEP 96160-000, Brazil.
Article Synopsis
- * Traditional vaccines for these toxins face challenges in production and effectiveness, prompting interest in recombinant vaccines and the need for better understanding of lesser-studied toxins.
- * The study highlights the potential of immunoinformatics to map immunodominant regions of these toxins, guiding future research to develop more effective vaccination strategies against severe animal infections.
An autopsy case of gas gangrene, massive intravascular hemolysis, and cytokine storm due to type A infection.
IDCases
October 2024
Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.
Article Synopsis
- Bacteremia is a serious and often deadly condition, particularly in cases with massive intravascular hemolysis, gas gangrene, and septic shock, as highlighted by the autopsy of an 84-year-old female patient.
- The patient experienced rapid health decline, progressing to septic shock within an hour of symptoms and ultimately dying a few hours later, linked to the development of gas-filled abscesses from gas-producing bacteria.
- The study revealed a connection between specific bacterial toxins and the patient's severe inflammatory responses, indicating that the identified bacteria were responsible for the patient's severe condition and rapid demise.
[Fatal course of a fulminant gas gangrene of the right hemithorax].
Unfallchirurgie (Heidelb)
October 2024
Klinik für Unfallchirurgie und Orthopädie, Universitätsklinikum Knappschaftskrankenhaus Bochum, In der Schornau 23-25, 44892, Bochum, Deutschland.
Article Synopsis
- Gas gangrene is a rare but severe infection often caused by the pathogen Clostridium septicum, which can develop either from trauma or spontaneously, particularly in patients with conditions like occult colon carcinoma.
- Individuals with diabetes mellitus are at a higher risk for developing this infection, which has a high mortality rate of around 50%, even with aggressive treatment.
- Initial symptoms are vague, complicating early diagnosis, and treatment typically involves high-dose antibiotics, surgical removal of infected tissue, and sometimes hyperbaric oxygen therapy.
Gas gangrene with Clostridium septicum in a neutropenic patient.
Infection
October 2024
Department of Plastic Surgery and Hand Surgery, Cantonal Hospital Aarau, Aarau, Switzerland.
Article Synopsis
- Gas gangrene is a serious infection caused by Clostridium bacteria, often resulting in rapid tissue death and requiring quick, multidisciplinary medical intervention.
- The case describes a 62-year-old woman with neutropenic fever from chemotherapy for breast cancer, who initially showed signs of cellulitis but deteriorated into septic shock despite antibiotic treatment.
- After extensive surgical intervention and adjustment of her antibiotics, the patient stabilized and was eventually discharged for rehabilitation, underscoring the diagnostic and therapeutic challenges associated with infections in immunocompromised individuals.
Review of advances in molecular structure and biological function of toxin of .
Can J Vet Res
October 2024
College of Medical Technology, Chongqing Medical and Pharmaceutical College, 82 Daxuecheng Road, Chongqing 401331, PR China (Chongli Xu, She, Fu, Peng); School of Biology and Agriculture, Shaoguan University, Shaoguan 512005, PR China (Chongbo Xu).
Article Synopsis
- - Recent studies have focused on the molecular structure and biological function of a specific toxin produced by an anaerobic, spore-forming, Gram-positive bacillus, which can cause serious intestinal diseases.
- - This toxin is categorized into five types (A, B, C, D, and E) and is known for being highly lethal and damaging, functioning as a metalloenzyme that disrupts cell membranes.
- - Future research aims to understand how the toxin interacts with cell membranes and its role in platelet activation, which could lead to better disease management strategies and improved vaccine efficacy.
Clostridial gas gangrene involving the brain, gallbladder, heart, and soft tissue: A case report and literature review.
IDCases
September 2024
Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Article Synopsis
- Clostridial gas gangrene (CGG) is a severe, fast-spreading infection with near-100% mortality if untreated, often linked to trauma but can arise spontaneously in immunocompromised individuals.
- Quick recognition and treatment are crucial, as CGG symptoms develop rapidly and require urgent surgical and antimicrobial care.
- A case study of a 73-year-old woman with spontaneous CGG illustrates the disease's severity; despite intensive treatment, she died from metastatic infection within 48 hours.
The presence of differentiated C2C12 muscle cells enhances toxin production and growth by type A strain ATCC3624.
Virulence
December 2024
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Article Synopsis
- Type A strains of bacteria cause gas gangrene by infecting muscle, where alpha toxin (PLC) and perfringolysin O (PFO) play significant roles in disease development.
- In this study, muscle cell line C2C12 was used to investigate how these toxins may help the bacteria by releasing nutrients from muscle cells.
- Results showed that differentiated C2C12 cells increase the production of PLC and PFO and that these toxins are cytotoxic, supporting bacterial growth by damaging muscle cells and releasing essential nutrients.
Fatal Clostridium septicum gas gangrene complicating ECMO: case report and review of literature.
Access Microbiol
August 2024
Critical Care Unit, Department of Anaesthesia, Critical Care and Perioperative Medicine, University Hospital of Rennes, Rennes, France.
Article Synopsis
- Gas gangrene is a serious infection caused by a specific type of bacteria, and it can occur either due to trauma or spontaneously without an apparent injury.
- This report presents a case where a patient suffered from a severe form of gas gangrene following cardiac arrest and needed advanced life support through ECMO.
- The study also highlights the complications of diagnosing and treating spontaneous gas gangrene while emphasizing the importance of appropriate antibiotic treatment before starting ECMO.
Clostridial Myonecrosis: A Comprehensive Review of Toxin Pathophysiology and Management Strategies.
Microorganisms
July 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Article Synopsis
- Clostridial myonecrosis, or gas gangrene, is a serious and fast-moving bacterial infection that affects muscles and soft tissues, with around 1000 cases annually in the U.S. and even more in developing nations.
- It is primarily caused by the Clostridium bacteria, which thrive in low-oxygen environments from injuries, leading to two types: traumatic (from injuries) and spontaneous (in immunocompromised individuals).
- Symptoms include severe pain and swelling, rapid tissue death, and systemic effects if untreated; diagnosis relies on clinical assessments and imaging, while treatment consists of surgery, antibiotics, and possibly hyperbaric oxygen therapy.
Salvage radiofrequency ablation for microwave ablation treated hepatocellular carcinoma complicated by gas gangrene: case report.
J Ultrasound
September 2024
Malattie Apparato Digerente, ASL Salerno, Ospedale L. Curto, Polla, Italy.
Article Synopsis
- Gas gangrene (GG) is a rare but severe infection often caused by Clostridium species, commonly developing after surgeries.
- A case study describes a 76-year-old woman who developed GG in the liver after a microwave (MW) ablation for liver cancer, initially misdiagnosed as an anaerobic liver abscess.
- The successful treatment involved percutaneous Radiofrequency ablation (RFA) when antibiotics failed, suggesting RFA as a potential option for GG when surgery isn't feasible.
Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against Infection.
Int J Mol Sci
June 2024
State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
Article Synopsis
- Absent in melanoma 2 (AIM2) is an important protein that detects foreign DNA from bacteria and viruses, but its role in fighting infections from extracellular bacteria is not well understood.
- Research shows that mice lacking AIM2 are more vulnerable to infections caused by a specific type of bacteria (identified as "pathogenic ."), indicating that AIM2 is crucial for protecting the host.
- The study reveals that AIM2 helps activate inflammasome signaling, which is essential for effectively killing and clearing bacterial infections, particularly through recognizing DNA from these pathogens.
Purinergic Receptor Antagonists Inhibit Hemolysis Induced by Alpha Toxin.
Pathogens
May 2024
State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing 100071, China.
Article Synopsis
- Alpha toxin (CPA) is a harmful substance produced by certain bacteria that causes diseases like yellow lamb disease in sheep and food poisoning in humans, primarily affecting blood cells through hemolysis.
- Recent research indicates that CPA-induced hemolysis relies on the activation of purinergic P2 receptors, revealing that both CPA and another non-pore-forming toxin, β-Hemolysin, use this mechanism.
- The study found that CPA activates specific pathways (PI3K/Akt and MEK1/ERK1) leading to the production of reactive oxygen species, which ultimately contribute to the damage of red blood cells.
Hyperbaric oxygen treatment in bilateral orchiopexy and post-circumcision haematoma in a thrombocytopenic patient with Noonan syndrome.
Diving Hyperb Med
June 2024
Pediatric Urology, Eskişehir Osmangazi University, Turkey.
Article Synopsis
- Hyperbaric oxygen treatment (HBOT) is effective for various conditions like necrotising soft tissue infections and delayed wound healing.
- A 17-month-old boy with multiple health issues developed ischaemic symptoms after surgery, prompting the use of HBOT alongside other treatments.
- His condition showed rapid improvement within five days, suggesting HBOT as a beneficial option for similar cases, with no prior reports in existing literature.
Article Synopsis
- The article discusses the corrections made to previously published research, providing updated data or insights.
- It highlights specific areas where inaccuracies were identified and clarifies the implications of these corrections for future studies.
- The importance of maintaining academic integrity and the role of peer review in the correction process is emphasized.
Gas Gangrene of the Spleen Caused by Clostridium perfringens After Mild Blunt Trauma.
Cureus
April 2024
Department of Gastroenterological Surgery, Shizuoka General Hospital, Shizuoka, JPN.
Article Synopsis
- - A 73-year-old woman developed splenic gas gangrene after blunt abdominal trauma, leading to symptoms like fatigue, dyspnea, and left-sided abdominal pain.
- - Diagnostic imaging revealed gas in the spleen and pleural effusion, prompting treatment with antibiotics and a splenectomy.
- - The bacteria causing the infection was identified from blood cultures; due to its normal presence in the gut, it should be suspected as a possible pathogen in similar splenic cases.
Hematological investigations in a case of intravascular hemolysis due to infection.
Biochem Med (Zagreb)
June 2024
Clinical Institute of Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Article Synopsis
- A patient with hip trauma presented with fever and severe pain, leading to an urgent fasciotomy and laboratory tests that revealed anemia and severe infection.
- After initial testing, the laboratory noted severely hemolyzed samples and repeated draws also resulted in hemolysis, indicating a potential underlying issue.
- The confirmed diagnosis of gas gangrene was linked to hemolysis caused by α-toxin from an anaerobic gram-positive bacterium, prompting a review of laboratory procedures to identify causes of intravascular hemolysis.
Spontaneous gas gangrene of the pancreas: extremely rare condition.
J Surg Case Rep
April 2024
University of Sousse, Sousse 4200, Tunisia.
Article Synopsis
- Acute pancreatitis is a frequently occurring condition that can sometimes lead to serious complications like necrosis of the pancreas, but this is not very common.
- When abscesses form in the pancreas, they are usually caused by a mix of both aerobic (oxygen-requiring) and anaerobic (not requiring oxygen) bacteria found in the intestines.
- The case discussed involves a patient who had clostridial emphysematous pancreatitis, which resulted in gas in the abdominal cavity (pneumoperitoneum) without any holes or tears in the surrounding organs.
A case of gas gangrene caused by Clostridium septicum with undiagnosed advanced colon cancer.
J Dermatol
August 2024
Department of Dermatology, Gifu Municipal Hospital, Gifu, Japan.
Catheter-related gas-forming suppurative thrombophlebitis.
Int J Emerg Med
March 2024
Department of Emergency and Critical Care Medicine, Saku Central Hospital Advanced Care Center, Nakagomi, Saku, Nagano, 3400-28, Japan.
Article Synopsis
- Catheter-related suppurative thrombophlebitis (CRST) is a serious infection related to catheter use, often linked to catheter-related bloodstream infections (CRBSI).
- The microbiological profile of CRST aligns closely with that of CRBSI, but Clostridium perfringens, which causes gas gangrene, is an uncommon pathogen in these cases.
- A case study highlights that the presence of gas-forming thrombus around the catheter can aid in the early diagnosis of this specific type of thrombophlebitis caused by Clostridium perfringens.
Article Synopsis
- Gas gangrene is a rare but serious infection that can occur after intramuscular injections, leading to severe complications and potentially death, as demonstrated in a case study involving a diabetic patient who received diclofenac and vitamin B12 injections.
- The patient experienced increasing pain and swelling after the injections, was diagnosed with gas gangrene in the emergency department, and ultimately died from sepsis and acute kidney injury despite intensive medical treatment.
- The report highlights the challenges faced by forensic pathologists in linking the infection to the injections, as well as the difficulty in identifying the causative organisms, underscoring the importance of blood cultures in both ante-mortem and postmortem settings.
Clostridial Catastrophe in Orthopedics - A Case Report.
J Orthop Case Rep
January 2024
Department of Orthopaedics, Velammal Medical College Hospital and Research Institute, Madurai, Tamil Nadu, India.
Article Synopsis
- A 51-year-old man with a Gustillo-Anderson type II fracture from a bicycle accident developed severe left forearm symptoms and was transferred to a hospital due to his deteriorating condition and a history of poorly controlled type 2 diabetes mellitus.
- Upon arrival, he exhibited severe signs of infection, including fever, limb swelling, and the presence of gas in his forearm, leading to a provisional diagnosis of gas gangrene confirmed by culture.
- Immediate emergency surgery was performed, resulting in limb amputation, and despite aggressive treatment including antibiotics and further surgeries, the patient recovered and was discharged 20 days later, highlighting the need for quick recognition and comprehensive care for severe infections.
Infective Endocarditis by and Species-A Narrative Review.
Antibiotics (Basel)
December 2023
School of Medicine, University of Crete, 71003 Heraklion, Greece.
Article Synopsis
- Bacteria from the genus being studied are Gram-positive, spore-forming, and can cause serious infections through toxin production, including diseases like colitis and gas gangrene.
- This study reviewed cases of infective endocarditis (IE) caused by these bacteria, analyzing data from 20 studies and 21 patients, revealing common valve involvement and clinical symptoms like fever and sepsis.
- Treatment often involved beta-lactams and metronidazole, with surgery needed in nearly half of the cases; however, mortality rates were significant, particularly for patients with multiple valve involvement.