86 results match your criteria: "Clocheville Hospital[Affiliation]"

Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report.

Virchows Arch

January 2019

Department of Dermatology, Unit of Pediatric Dermatology - CHRU Tours, Tours, France.

Cutaneous spindle-cell neoplasms in adults as well as children represent a frequent dilemma for pathologists. Along this neoplasm spectrum, the differential diagnosis with CD34-positive proliferations can be challenging, particularly concerning neoplasms of fibrohistiocytic and fibroblastic lineages. In children, cutaneous and superficial soft-tissue neoplasms with CD34-positive spindle cells are associated with benign to intermediate malignancy potential and include lipofibromatosis, plaque-like CD34-positive dermal fibroma, fibroblastic connective tissue nevus, and congenital dermatofibrosarcoma protuberans.

View Article and Find Full Text PDF

The learning curve of robot-assisted laparoscopic pyeloplasty in children: a multi-outcome approach.

J Pediatr Urol

December 2018

Pediatric Surgery Department, University Teaching Hospital of Tours, Gatien de Clocheville Hospital, 37000 Tours, France.

Introduction: Few studies have evaluated the learning curve (LC) for robot-assisted laparoscopic pyeloplasty (RALP) for ureteropelvic junction obstruction in children. It was attempted to assess the LC of this procedure using a multi-outcome approach, accounting for patient complexity.

Material And Methods: Data on the first series of children undergoing RALP between November 2007 and December 2017 at the study institution were prospectively collected.

View Article and Find Full Text PDF

Objective: The aim of the study was to better describe incidence, risk factors, and the natural evolution of neonatal portal vein thrombosis (PVT).

Study Design: One hundred and twenty-three premature newborns or with birth weight <1.5 kg were prospectively included in a single center during a one-year period.

View Article and Find Full Text PDF

From classical surgery to robot-assisted surgery (RAS), there has been a long way allowed by the improvements achieved in minimally invasive surgery (MIS). The last three decades have witnessed a prodigious development of MIS, and especially in the field of laparoscopic pediatric surgery but there are several limitations in the use of conventional laparoscopic surgery and RAS was developed to relieve these drawbacks. This new technology enables today the performance of a wide variety of procedures in children with a minimally invasive approach.

View Article and Find Full Text PDF

Laparoscopic one port appendectomy: Evaluation in pediatric surgery.

J Pediatr Surg

November 2018

Pediatric Surgery Unit, Hospital, Universitary Center of Tours, Gatien de Clocheville Hospital, 37000 Tours, France.

Background: Appendectomy is a well-established surgical procedure in pediatric surgery used in the management of acute appendicitis. With the continuous advancement in the field of minimal invasive surgery, the recent focus is on single incision laparoscopic (SIL) surgery. SILA also goes further in order to decrease pain, improve recovery and enhance patient satisfaction.

View Article and Find Full Text PDF

Computer-Assisted Surgery in Facial Bipartition Surgery.

J Oral Maxillofac Surg

May 2018

Professor, François Rabelais University, Maxillofacial and Facial Plastic Surgery Department, Trousseau Hospital, Tours; Reference Center for Rare Craniofacial Malformations, Clocheville Hospital, Tours, France.

Purpose: Frontonasal dysplasia or median cleft syndrome is a rare condition often associated with transverse maxillary deficiency for which facial bipartition is the proper surgical treatment. This technical note describes the use and efficacy of 3-dimensional virtual surgical planning and patient-specific cutting guides in facial bipartition.

Materials And Methods: An 11-year-old boy presented with frontonasal dysplasia and a midline facial cleft.

View Article and Find Full Text PDF

Purpose: The aim of this study was to compare the radiation dose, image quality and 3D spine parameter measurements of EOS low-dose and micro-dose protocols for in-brace adolescent idiopathic scoliosis (AIS) patients.

Methods: We prospectively included 25 consecutive patients (20 females, 5 males) followed for AIS and undergoing brace treatment. The mean age was 12 years (SD 2 years, range 8-15 years).

View Article and Find Full Text PDF

Purpose: Although lumbar spondylolysis is encountered in general population with an incidence estimated to be 3-10%, limited information is available for children. The aim of the study is to determine the prevalence of spondylolysis according to associated vertebral bony malformation and spinopelvic parameters in children under eight requiring CT evaluation for unrelated lumbar conditions.

Methods: Seven hundred and seventeen abdominal and pelvic multi-detector CT scans were obtained in patients under 8 years of age were reviewed.

View Article and Find Full Text PDF

A chronic swelling of the mandible in a child.

J Stomatol Oral Maxillofac Surg

February 2018

Department of Maxillofacial and Facial Plastic Surgery, Trousseau Hospital, University of François-Rabelais, 37000 Tours, France; Department of Pediatric Maxillofacial and Facial Plastic Surgery, Clocheville Hospital, University of François-Rabelais, 37000 Tours, France.

View Article and Find Full Text PDF

Polyurethane versus silicone port a cath: What's going on at removal?

J Pediatr Surg

July 2018

Pediatric Surgery Unit, Hospital Universitary Center of Tours, Gatien de Clocheville Hospital, 37000 Tours, France. Electronic address:

Background: Port-a-cath (PAC) is an essential device in the management of the patients of chronic illness, but despite theirs benefits there are many complications either at the time of insertion or at time of removal. Our aim of this study is to evaluate the fracture rate of the catheter at removal time in comparison with catheter type either polyurethane or silicone.

Methods: A retrospective monocentric study of all PACs which were removed at our university pediatric hospital between 1 January 2006 and 31 December 2016.

View Article and Find Full Text PDF

Background The aim of this preliminary study is to evaluate the results of T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in pediatric patients at 1.5T, with a low peripheral intravenous gadoteric acid injection rate of 1 ml/s. Materials and methods Children with neurological symptoms were examined prospectively with conventional MRI and T1-weighted DCE MRI.

View Article and Find Full Text PDF

Sonography of suspected acute appendicitis in children: Evaluation of the progress in performance of senior residents.

J Pediatr Surg

April 2018

Pediatric Radiology Department, Clocheville Hospital, 49 Boulevard Beranger, 37000, University Hospital Tours, France; Faculty of Medicine, Francois Rabelais University, Tours, France. Electronic address:

Purpose: The objective of this study was to evaluate the progress in performance of senior residents in diagnosing acute appendicitis.

Material And Methods: Results were collected and compared of ultrasound examinations performed for suspected acute appendicitis by three senior residents and two faculty members over a six-month period in a university hospital setting. A grid with the sonographic findings was completed separately by the residents and the faculty members immediately after each examination.

View Article and Find Full Text PDF

Introduction: Preoperative information is a legal and ethical obligation. Very little studies have evaluated the preoperative information method in pediatrics. Having a child operated on is stressful for the parents.

View Article and Find Full Text PDF

Use of cutting guides during craniosynostosis sequelae surgery: A comparative study between computer-assisted planning and post-operative results.

J Craniomaxillofac Surg

July 2017

Department of Maxillofacial Surgery, Centre Hospitalier Universitaire de Tours, France; Department of Craniofacial Surgery, Clocheville Hospital, Centre Hospitalier Universitaire de Tours, France; Université of Medecine François Rabelais, Tours, France.

Background: The authors compared results of craniofacial reconstruction surgery using cutting guides with planned reconstruction on patients presenting craniosynostosis surgery sequelae.

Methods: This is a retrospective study performed on seven patients who had undergone craniofacial reconstructive surgery in University Hospital Center of Tours (France) in 2015. Patients had long-term sequelae of trigonocephaly and anterior plagiocephaly surgery.

View Article and Find Full Text PDF

Background: Branch pulmonary artery (BPA) stenosis is frequently associated with congenital heart disease. Management of BPA stenosis is challenging for surgeons due to a high rate of recurrence. The purpose of this study was to assess the results of intraoperative pulmonary artery stenting associated with or without surgical angioplasty.

View Article and Find Full Text PDF

Objective: Rasmussen's encephalitis (RE) is a severe chronic inflammatory brain disease affecting one cerebral hemisphere and leading to drug-resistant epilepsy, progressive neurologic deficit, and unilateral brain atrophy. Hemispherotomy remains the gold standard treatment but causes permanent functional impairment. No standardized medical treatment protocol currently exists for patients prior to indication of hemispherotomy, although some immunotherapies have shown partial efficacy with functional preservation but poor antiseizure effect.

View Article and Find Full Text PDF

Background: Mutations in Phenylalanine Hydroxylase (PAH) gene cause phenylketonuria. Sapropterin (BH4), the enzyme cofactor, is an important therapeutical strategy in phenylketonuria. However, PAH is a highly polymorphic gene and it is difficult to identify BH4-responsive genotypes.

View Article and Find Full Text PDF

Biological treatment in systemic juvenile idiopathic arthritis: achievement of inactive disease or clinical remission on a first, second or third biological agent.

RMD Open

October 2015

Department of Paediatric Immunology, Hematology and Rheumatology and Institut IMAGINE , Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris , Paris , France ; Université Paris-Descartes, Paris , France.

Objectives: To analyse the effect of biological agents (BAs) in terms of achieving inactive disease (ID) or clinical remission (CR) in patients with systemic juvenile idiopathic arthritis (SJIA), to describe effects of switching or discontinuing a BA and to assess the proportion of patients able to maintain ID or CR off steroids and after withdrawing BA therapy.

Methods: Retrospective study in a French paediatric rheumatology reference centre using the CEMARA (CEntre des MAladies RAres) register.

Results: Seventy-seven patients were included with a cumulative follow-up of 245.

View Article and Find Full Text PDF

Stenting in paediatric and adult congenital heart diseases: A French multicentre study in the current era.

Arch Cardiovasc Dis

December 2015

Groupe de cathétérisme interventionnel pédiatrique et congénitale/filiale de cardiologie pédiatrique et congénitale de la société française de cardiologie, France; Paediatric and congenital cardiology, La Timone Hospital, M3C CHU de Marseille, Marseille, France; Royal Brompton Hospital, London, England, UK.

Background: Many stents are used "off-label" during the management of congenital heart diseases (CHD).

Aims: To describe indications for, results of, and adverse events associated with stenting in CHD in current practice.

Methods: Participation in this study was proposed to all catheterization laboratories that specialize in CHD in France (M3C network).

View Article and Find Full Text PDF

Frontofacial Monobloc Advancement With Simultaneous Frontal Cranioplasty in Adolescents With Residual Apert Syndrome Deformations.

J Craniofac Surg

October 2015

*Department of Plastic Facial Surgery †Department of Paediatric Maxillo-facial ‡Department of Paediatric Neurosurgery, Clocheville Hospital, Faculty of Medicine of Tours, François Rabelais University, Tours, France.

Introduction: The treatment of faciocraniosynostosis has steadily evolved since the introduction of craniofacial surgery in the 1950s. The aim of this study is to demonstrate the positive results obtained by frontofacial monobloc advancement with simultaneous frontal cranioplasty in adolescents with adult facial bones and residual Apert syndrome deformations.

Materials And Methods: Three adolescents underwent surgery between September 1, 2010 and March 31, 2011.

View Article and Find Full Text PDF

Comprehensive PKD1 and PKD2 Mutation Analysis in Prenatal Autosomal Dominant Polycystic Kidney Disease.

J Am Soc Nephrol

March 2016

Assistance Publique des Hôpitaux de Paris, Centre de référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte (MARHEA), Department of Pediatric Nephrology, University Hospital Necker-Enfants Malades Paris, France;

Prenatal forms of autosomal dominant polycystic kidney disease (ADPKD) are rare but can be recurrent in some families, suggesting a common genetic modifying background. Few patients have been reported carrying, in addition to the familial mutation, variation(s) in polycystic kidney disease 1 (PKD1) or HNF1 homeobox B (HNF1B), inherited from the unaffected parent, or biallelic polycystic kidney and hepatic disease 1 (PKHD1) mutations. To assess the frequency of additional variations in PKD1, PKD2, HNF1B, and PKHD1 associated with the familial PKD mutation in early ADPKD, these four genes were screened in 42 patients with early ADPKD in 41 families.

View Article and Find Full Text PDF

The translation of new treatments based upon established evidence into clinical practice is often difficult. The establishment of a therapeutic hypothermia (TH) service and a related cooling register would provide the opportunity to examine how a new therapy becomes implemented in a country or region. The objectives of a TH program should be: to provide guidance to clinicians who are considering the introduction of this new therapy; to ensure standardized clinical practices; to audit the implementation and conduct of TH; to provide surveillance for cooling-related adverse effects; and to evaluate the subsequent neurodevelopmental outcome.

View Article and Find Full Text PDF

Cortical involvement in focal epilepsies with epileptic spasms.

Epilepsy Res

November 2014

Hôpital Henri Gastaut, Marseille, France; Service de Neurophysiologie Clinique, Assistance Publique des Hôpitaux de Marseille, Marseille F-13005, France. Electronic address:

The pathophysiological mechanisms of epileptic spasms are still poorly understood. The role of subcortical structures has been suggested on the basis of non-localized EEG features and from experimental data. The description of asymmetric spasms associated with lateralized EEG patterns has challenged this view and raises the possibility of a cortical origin.

View Article and Find Full Text PDF

The use of computed tomography and nuclear medicine examinations in paediatric oncology: An analysis of practice in a university hospital.

Diagn Interv Imaging

April 2014

Department of Paediatric Radiology, Tours Regional University Hospitals, Clocheville Hospital, 49, boulevard Béranger, 37000 Tours, France.

Purpose: The purpose of this study is to evaluate, in terms of number of examinations and how effective doses are distributed by location and chronology, the use of CT and nuclear medicine examinations in the management of paediatric oncology patients.

Materials And Methods: This was a retrospective and descriptive study that included 57 children (13 with neonatal neuroblastoma, 18 with renal tumours, and 26 with lymphoma) over a 5-year period, with the length of monitoring ranging from 1 to 7 years. All CT scans and nuclear medicine examinations were counted, and the effective doses calculated.

View Article and Find Full Text PDF