[Alternative therapies for choroidal neovessels resulting from age-related macular degeneration].

Classic neovessels (CNVs) identified on fluorescein angiography may benefit from thermal laser photocoagulation when sparing the fovea. If they extend into it, photodynamic therapy may halt the natural progression to a central scotoma. Occult CNVs, when subfoveal, may benefit from photodynamic therapy when isolated (not associated with classic CNV or with a pigment epithelium detachment).

[Decompensation of a cirsoid aneurysm: a case report].

We report a case of a 27-year-old woman with a cirsoid aneurysm, also called congenital arteriovenous communication of the retina. The cirsoid aneurysm, stage I according to Archer's classification, was revealed by a serous retinal detachment. The exudation resolved, and acuity was recovered after a short time, but exudation recurred during the 5 years of follow-up.

[Age-related macular degeneration and apoptosis].

Several studies suggest that apoptosis might play a major role in age-related macular degeneration. Apoptosis in retinal pigment epithelium cells undergoing severe oxidative stress has been reported and could therefore be involved in the pathogenesis of AMD. The processes of drusen formation seem to be similar to the processes described in apoptosis.

Implantation of Intacs and a refractive intraocular lens to correct keratoconus.

We report a case of Intacs implantation for keratoconus followed by the implantation of an anterior chamber phakic refractive lens to correct a -8.25 diopter residual error.

[Treatment of benign eyelid conditions with Argon laser].

Eyelid surgery is not always uneventful. Complications (punctal ectropion, retractile scars) can sometimes occur. Argon laser treatment is an interesting alternative technique, particularly in cases with cosmetic indications.

[Diabetic cystoid macular edema and vitrectomy. Preliminary results: about 19 cases].

Introduction: Vitrectomy can be performed to release the anteroposterior and tangential vitreoretinal tractions that sometimes create diabetic macular edema. The present study evaluates the efficacy of this treatment.

Material And Methods: We retrospectively studied 19 operated eyes in 15 patients with diabetes over 17 months.

[Study of internal limiting membrane peeling in stage-3 and -4 idiopathic macular hole surgery].

Purpose: To evaluate the advantages of peeling the internal limiting membrane (ILM) in macular hole surgery.

Patients And Methods: Retrospective analysis of the results of macular hole surgery, comparing two surgical protocols performed by the same surgeon. Both protocols included a standard pars plana vitrectomy with intravitreous nonexpansile gas and adjunction of autologous plasma over the macular hole.

[Sarcoid granuloma simulating amelanotic melanoma of the iris: a case report].

We report the case of a unilateral vascular iris tumor in a 24-year-old patient. Clinically, the iris lesion appeared similar to amelanotic melanoma. A systemic work-up (initial check-up), including an angiotensin-converting enzyme determination, provided the diagnosis of sarcoid granuloma.

[Photodynamic therapy].

Photodynamic therapy with Verteporfine (Visudyne Novartis Ophthalmics) achieves a photo occlusion of subfoveal choroidal neovascularization (CNV) resulting from age-related macular degeneration (AMD) in phase 1 and 2 studies. Thereafter, two international randomized clinical trials evaluated the product's efficacy in term of visual acuity. Eyes with neovascular lesions due to AMD of less than 5,400 micro, in size involving the fovea and presenting well-defined CNV on fluorescein angiography could be included when visual acuity was between 5 and 1/10.

[Progression of choroidal neovascularization after macular translocation in age-related macular degeneration and degenerative myopia].

Purpose: To study the progression of choroidal neovascularization (CNV) after macular translocation in age-related macular degeneration (AMD) and degenerative myopia.

Patients And Methods: The data from 42 consecutive eyes (28 AMD, and 14 degenerative myopia) operated on by limited macular translocation (DeJuan technique), with a follow-up of 6 months or more, were prospectively analyzed. In the AMD group, neovascularization was classic in 54% of eyes and classic and occult in 46% of eyes.

[Corneal herpes: what's new?].

The prognosis of herpetic keratitis has been dramatically improved during the past years because of a better understanding of their physio-pathologic phenomenons, and mostly because of the use of very efficient antiviral drugs. Superficial keratitis are easily cured in most cases; deep stromal keratitis, that often require corticosteroid treatment, are more difficult to heal. Prophylactic treatment of the recurrences by oral antiviral drugs represents a promising new concept for herpetic keratitis.

[Age-related macular degeneration].

Unlabelled: EPIDEMIOLOGICAL AND PATHOGENIC DATA: Age-related macular degeneration (ARMD) is the first cause of blindness in industrialized countries in patients over the age of 55. Its prevalence increases with age, affecting up to 25% of the population aged over 75. The pathogenesis of this disease is not well known.

[Choroidal nevi associated with serous macular detachment].

Purpose: To describe the aspect and progression of choroidal nevi associated with macular serous detachment and to analyze different treatments.

Material: and methods: Twelve posterior choroidal nevi were associated with subretinal fluid. The fovea was detached in 11 cases.

[Macular coloboma type Leber's congenital amaurosis].

Three brothers, with the macular coloboma type Leber's congenital amaurosis aged 10, 8, and 6 years respectively, are described in this report. Only the two elder brothers were symptomatic while the third patient had no complaint at the time of diagnosis. The patients had no associated systemic or ocular disorders, including nystagmus.

[Argon laser photocoagulation of circumscribed choroidal hemangiomas].

Purpose: Therapeutic retrospective results obtained after Argon laser photocoagulation of 17 circumscribed choroidal hemangiomas were analyzed.

Material And Methods: Seventeen circumscribed choroidal hemangiomas associated with serous retinal detachment were analyzed. All patients were symptomatic but one.

[Gyrate atrophy of late disclosure].

Gyrate atrophy of the choroid and retina is a chorioretinal degeneration caused by a deficiency of ornithine aminotransferase. We report the case of a 29-year-old woman who showed an advanced stage of gyrate atrophy of the choroid and retina fortuitously discovered. Examination of the patient provided an opportunity to describe pathophysiology, knowledge on the ornithine aminotransferase gene, and finally the therapeutics used in this disease.

[Radiation-induced retinopathy].

Radiation retinopathy is observed after intraocular tumor irradiation (mainly uveal melanomas, retinoblastoma being more seldom) or intracranial tumours radiotherapy. Today radiation retinopathy is also seen after irradiation for choroidal neovascularization observed in age-related macular degeneration. Radiation retinopathy after posterior uveal tumor irradiation will be described.

[Age-related macular degeneration and genetics].

Age related macular degeneration (AMD) is the main cause of blindness after age 55 in western countries. These last past years, several lines of evidence such as familial aggregation or twin studies suggested a genetic component in AMD. However, the late onset of the disease and the fact that AMD is a polygenic and multifactorial disease are the main limiting factors for linkage studies.

[Optical coherence tomography in the follow up of macular edema treatment in retinitis pigmentosa].

Macular edema is frequently responsible for loss of central vision in patients affected with retinitis pigmentosa (RP). This macular edema can be treated with acetazolamide. Our purpose was to evaluate optical coherence tomography (OCT) examination in the follow-up of macular edema in RP.

[New therapies for the treatment of age-related macular degeneration].

Age-related macular degeneration has a natural progression from the precursors (the drusen) towards atrophic or neovascular complications. Choroidal neovascularization is undoubtedly the aspect of the disease that benefits most from new therapeutical approaches. Destructive photocoagulation based on fluorescein angiography has demonstrated since 20 years its efficiency on choroidal neovascularization.

[Conjunctival epithelial carcinoma in a 9-year-old child with xeroderma pigmentosum. Case report].

We report the case of a conjunctival tumor in a 9-year-old patient, suffering from Xeroderma Pigmentosum. Our patient presented a raspberry-colored conjunctival tumor. The tumor was resecked without any additional treatment.

[Photodynamic therapy in choroidal new vessels].

Photodynamic therapy (PDT) is a new approach for subfoveal choroidal new vessels (CNV) in age-related macular degeneration (ARM) and myopia, currently being evaluated in clinical trials. PDT is a two-step procedure: the intravenous perfusion of a photosensitizer is followed by light irradiation at the adapted wavelength. Verteporfin, the photosensitizer under investigation, has a maximum absorption at 692nm.