2 results match your criteria: "Clinical University Hospital Virgen de la Arrixaca (IMIB-Arrixaca)[Affiliation]"
Cardiolipin in Immune Signaling and Cell Death.
Trends Cell Biol
November 2020
Molecular Inflammation Group, Biomedical Research Institute of Murcia, Clinical University Hospital Virgen de la Arrixaca (IMIB-Arrixaca), Carretera Buenavista s/n, Murcia 30120, Spain.
Cardiolipin (CL) is a tetra-acylated diphosphatidylglycerol lipid. In physiological conditions, CL presents unsaturated chains and is located in the inner mitochondria membrane (IMM). Dead signals, infection, or disease may change the level of CL saturation and oxidation and cause its translocation to the cytosolic side of the outer mitochondrial membrane (OMM), affecting mitochondrial function and the inflammatory response.
View Article and Find Full Text PDFHepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis.
J Hepatol
January 2021
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. Electronic address:
Background & Aims: Increased hepatocyte death contributes to the pathology of acute and chronic liver diseases. However, the role of hepatocyte pyroptosis and extracellular inflammasome release in liver disease is unknown.
Methods: We used primary mouse and human hepatocytes, hepatocyte-specific leucine 351 to proline Nlrp3CreA mice, and Gsdmd mice to investigate pyroptotic cell death in hepatocytes and its impact on liver inflammation and damage.