9 results match your criteria: "Clinical Trials Center Cardiovascular Research Foundation New York NY.[Affiliation]"
Comparison of Ridaforolimus-Eluting and Zotarolimus-Eluting Coronary Stents: 5-Year Outcomes From the BIONICS and NIREUS Trials.
J Am Heart Assoc
November 2024
Department of Cardiology, Tel Aviv Sourasky Medical Center, Affiliated with the School of Medicine Tel Aviv University Tel Aviv Israel.
Article Synopsis
- The BIONICS and NIREUS trials compared the ridaforolimus-eluting stent (RES) and zotarolimus-eluting stent (ZES), showing that RES was noninferior to ZES for 1-year target-lesion failure and 6-month lumen loss.
- A pooled analysis of 2221 patients over 5 years found similar rates of target-lesion failure (12.2% for RES vs 11.3% for ZES), with no significant differences in other outcomes like myocardial infarction or stent thrombosis.
- Although the RES group had higher rates of target-vessel revascularization and cardiac death, these differences were not significant after adjusting for patient characteristics, indicating long-term
Article Synopsis
- The VIRGO study analyzed 3,572 young adults (ages 18-55) who experienced an acute myocardial infarction (AMI), focusing on the effects of obstructive sleep apnea (OSA) on health outcomes, particularly by sex.
- About 49% of patients were identified as high risk for OSA, but only 4.7% had a prior diagnosis, highlighting a significant gap in awareness.
- Women at high risk for OSA showed significantly worse physical and mental health outcomes compared to their male counterparts, suggesting they are more adversely affected by the condition following an AMI.
Article Synopsis
- The study investigates the impact of peripheral artery disease (PAD) on the outcomes of transcatheter mitral valve repair (TMVr) in heart failure (HF) patients with severe mitral regurgitation, comparing results with guideline-directed medical therapy (GDMT) alone.
- Among 614 patients, 109 had PAD; findings showed that PAD was linked to higher mortality but did not affect hospitalization rates for heart failure.
- TMVr significantly reduced mortality for patients without PAD, but not for those with PAD; however, it consistently decreased hospitalization rates and improved health status and exercise capacity for all patients regardless of PAD status.
Article Synopsis
- The study explored the relationship between high platelet reactivity (HPR) on clopidogrel and the risk of major adverse cardiac events (MACE) in patients undergoing coronary interventions, particularly focusing on those with diabetes mellitus (DM).
- Among the 8,582 patients in the study, it was found that HPR was more common in individuals with DM, and both groups (with and without diabetes) experienced increased rates of MACE linked to HPR.
- However, the impact of HPR on MACE risk differed based on diabetes type, with non-insulin-treated diabetes mellitus (non-ITDM) showing a stronger association compared to insulin-treated diabetes mellitus (ITDM).
Article Synopsis
- A study analyzed the effectiveness of the modified ACC/AHA lesion classification as a way to predict short- and long-term outcomes in patients undergoing percutaneous coronary intervention (PCI) with second-generation drug-eluting stents.
- Data from 8,516 patients revealed that those with complex lesions (B2/C) experienced higher instances of target lesion failure (TLF) compared to those with noncomplex lesions (A/B1) at multiple follow-up points (30 days, 1 year, and 5 years).
- The findings suggest that the historical ACC/AHA classification system remains relevant for predicting clinical outcomes after PCI, particularly highlighting worse outcomes for complex lesions after 5 years.
Background In-stent restenosis, especially for neoatherosclerosis, is a major concern following percutaneous coronary intervention. This study aimed to elucidate the association of features of in-stent restenosis lesions revealed by optical coherence tomography (OCT)/optical frequency domain imaging (OFDI) and the extent of lipid-rich neointima (LRN) assessed by near-infrared spectroscopy (NIRS) and intravascular ultrasound, especially for neoatherosclerosis. Methods and Results We analyzed patients undergoing percutaneous coronary intervention for in-stent restenosis lesions using both OCT/OFDI and NIRS-intravascular ultrasound.
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- The study examines the neutrophil-to-lymphocyte ratio (NLR) as a potential indicator of systemic inflammation and its link to prognosis in patients with severe aortic stenosis undergoing TAVR or SAVR.
- Data from 5881 patients showed that a higher baseline NLR significantly correlated with increased risks of death or rehospitalization after 3 years, highlighting its potential as a risk stratification tool.
- Additionally, a decrease in NLR levels within the first year post-surgery was associated with improved outcomes, further suggesting the importance of monitoring NLR in patient management.
Guideline-based medical therapy is the foundation of treatment for individuals with coronary artery disease. However, revascularization with either percutaneous coronary intervention or coronary artery bypass grafting may be beneficial in patients with acute coronary syndromes, refractory symptoms, or in other specific scenarios (eg, left main disease and heart failure). While the goal of percutaneous coronary intervention and coronary artery bypass grafting is to achieve complete revascularization, anatomical and ischemic definitions of complete revascularization and their methodology for assessment remain highly variable.
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