366 results match your criteria: "Clinical Research and Public Health[Affiliation]"

Background: Agriculture is a hazardous industry, with tractor-related incidents being among the leading causes of traumatic injury and death. These injuries tend to take place far away from hospitals, thus leading to increased prehospital time to receive care. Understanding the relationship between prehospital time and outcomes such as hospital length of stay and mortality in the state of Nebraska could inform resource allocation for tractor related injuries.

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Background: In dogs with idiopathic epilepsy (IE), 33% develop resistance to conventional anti-seizure medication (ASM) despite adequate treatment. In human medicine, an immune-mediated etiology is suspected in a subset of ASM-resistant patients with epilepsy and cerebrospinal fluid (CSF)-specific immunoglobulin G (IgG)-type oligoclonal bands (OCBs) have been detected. In dogs, cases of autoimmune encephalitis recently were reported.

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The Teachers' Knowledge of Type 1 Diabetes in Schools: An Interventional Study.

Curr Diabetes Rev

December 2024

Department of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, Mohammed 1st University, Oujda, Morocco.

Background: Managing type 1 diabetes in school is a real challenge for teachers, parents, and students themselves. Involving school educators in providing care and support is becoming more of a necessity than a luxury to facilitate access to healthcare services in schools for children with type 1 diabetes.

Objectives: Our work aimed to assess the background knowledge of teachers on type 1 diabetes and evaluate the impact of an educational intervention in improving this knowledge.

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Human craniofacial shape is highly variable yet highly heritable with numerous genetic variants interacting through multiple layers of development. Here, we hypothesize that Mendelian phenotypes represent the extremes of a phenotypic spectrum and, using achondroplasia as an example, we introduce a syndrome-informed phenotyping approach to identify genomic loci associated with achondroplasia-like facial variation in the general population. We compare three-dimensional facial scans from 43 individuals with achondroplasia and 8246 controls to calculate achondroplasia-like facial scores.

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Mapping genes for human face shape: Exploration of univariate phenotyping strategies.

PLoS Comput Biol

December 2024

Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, Belgium.

Human facial shape, while strongly heritable, involves both genetic and structural complexity, necessitating precise phenotyping for accurate assessment. Common phenotyping strategies include simplifying 3D facial features into univariate traits such as anthropometric measurements (e.g.

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Pregnancy revealing hereditary angioedema type III with factor XII mutation managed in a resource-limited setting with no C1-inhibitor concentrate availability: a case report.

Int J Obstet Anesth

October 2024

Department of Dermatology, Venerology and Allergology, CHU Mohammed VI, Oujda, Morocco; Laboratory of Epidemiology, Clinical Research and Public Health. Faculty of Medicine and Pharmacy, Mohammed Premier University, Oujda, Morocco.

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Background And Purpose: The literature lacks large studies on outcomes of cerebrovascular disease (CVD) in patients with muscular dystrophies (MDs). Previous studies primarily focused on ischemic stroke. CVD can add considerable morbidity in patients with MD.

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[Not Available].

Tunis Med

November 2024

Faculty of Medicine and Pharmacy of Oujda, Mohammed Premier University, 60000. Laboratory of Epidemiology, Clinical Research and Public Health (LERCSP). Morocco.

Introduction: Globally and in Morocco, viral hepatitis is a major public health priority, and knowledge and awareness are essential in the combat against this disease.

Aim: To assess the knowledge, attitudes and practices of university students regarding viral hepatitis.

Methods: A descriptive and analytical cross-sectional study was conducted among students enrolled at Mohammed Premier University in Oujda, for the 2023-2024 academic year, using a self-administered and anonymous online questionnaire.

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Is there any association between vitamin D status and PCOS disease?

Gynecol Endocrinol

December 2024

Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohamed the First University, Oujda, Morocco.

Article Synopsis
  • Polycystic ovary syndrome (PCOS) is a widespread hormonal disorder in women of reproductive age, and this study focused on evaluating vitamin D levels in women with PCOS compared to healthy controls.
  • The study analyzed 176 women, finding that 40.2% of those with PCOS had vitamin D deficiency, significantly higher than the 24% observed in healthy controls, and those with both PCOS and obesity or insulin resistance had even lower vitamin D levels.
  • The research suggests that vitamin D deficiency may play a role in the development of PCOS, particularly in women with obesity or insulin resistance, indicating that vitamin D supplementation could be helpful in managing the condition.
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Background: Smoking in pregnancy continues to cause significant morbidity to mothers and babies and contributes to tremendous costs to society. Maternal-fetal attachment (MFA) may differentiate smokers who quit or pregnant smokers from non-smokers. Researchers have recommended utilizing interventions that improve MFA to help decrease smoking within pregnancy.

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Introduction: Central line-associated bloodstream infections (CLABSI) are prevalent and preventable hospital-acquired infections associated with high morbidity and costs. Disparities based on race, ethnicity, and hospital factors remain underexplored. This study compares cost, length of stay, and mortality for adults with CLABSI by race-ethnicity, hospital location-teaching status, and geographic region in the United States using data from the National Inpatient Sample (NIS) database from 2016 to 2020.

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Left lateral-aortic paraganglioma in an adolescent: A rare case report.

Int J Surg Case Rep

December 2024

Department of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed First, Oujda, Morocco; Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy, University of Mohammed First, Oujda, Morocco. Electronic address:

Article Synopsis
  • Paraganglioma is a rare neuroendocrine tumor that occurs outside the adrenal gland, and its pediatric form is particularly uncommon.
  • A 15-year-old boy experienced a hypertensive crisis caused by a left lateral-aortic paraganglioma, which was successfully managed with alpha-1 blockers before the complete surgical removal of the tumor.
  • Early intervention is crucial to prevent complications from high blood pressure, and preoperative care is necessary to minimize risks during and after surgery.
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Environment and Health: Water and Soil Contamination.

FP Essent

October 2024

Department of Clinical Research and Public Health, Creighton University School of Medicine, Omaha, Nebraska.

Exposures to pollutants and contaminants can occur through water or soil, which can be contaminated naturally or through human activities. The toxicity and adverse health effects of these substances depend on exposure route, quantity, and duration. Mechanisms of water contamination include runoff, flooding, infrastructure failures, and contamination from air and surface water pollution.

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Environment and Health: Heavy Metal Toxicity.

FP Essent

October 2024

Department of Clinical Research and Public Health, Creighton University School of Medicine, Omaha, Nebraska.

Heavy metals are naturally occurring, high-density elements such as arsenic, cadmium, chromium, lead, and mercury. These five metals are the most common causes of heavy metal poisonings. Zinc is also of concern.

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Environment and Health: Poisoning Management.

FP Essent

October 2024

Department of Clinical Research and Public Health, Creighton University School of Medicine, Omaha, Nebraska.

Article Synopsis
  • - Poisoning is the top cause of unintentional injury deaths in the US, with 2 to 4 million exposures reported annually.
  • - Poison control centers (PCCs) collaborate with health care providers to identify and manage poisonings, offering expert support and education.
  • - Family physicians often serve as the first contact for patients with potential poison exposure symptoms and can consult PCCs for assistance in diagnosis and treatment.
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Article Synopsis
  • Researchers investigated how machine learning could improve predicting cardiomyopathy risk in childhood cancer survivors using echocardiograms from multiple centers.
  • They designed deep convolutional neural networks (DCNNs) to analyze different sets of echocardiographic data and gauge model performance using standard metrics like F1-score and AUPRC.
  • Results showed that the DCNN effectively distinguished between survivors who developed cardiomyopathy and those who didn't, suggesting a potential tool for early prediction in at-risk patients.
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Introduction: The debate remains open as to the difference in prevalence of mortality and occurrence of acute events in patients with Myocardial infarction with non-obstructive coronary arteries (MINOCA) and others with Myocardial infarction with coronary arteries disease (MI-CAD).

Methods: We conducted a 2-year retrospective study for patients admitted for Acute coronary syndrome (ACS) to analyze the clinical and prognostic characteristics of patients with MINOCA versus MI-CAD. We defined 1-year all-cause mortality as the primary outcome, and the secondary outcome as a composite of 1-year readmission for myocardial infarction or acute heart failure (AHF).

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Antiphospholipid syndrome (APS) is characterized by hypercoagulability, manifesting as venous or arterial thrombosis, and pregnancy-related complications, such as fetal loss, pre-eclampsia, and eclampsia. These conditions occur in the presence of antiphospholipid antibodies (aPL), including anticardiolipin antibodies (aCL) and/or a positive lupus anticoagulant (LA) test. Antiphospholipid syndrome (APS) can manifest as a primary, isolated condition or be associated with connective tissue diseases, such as systemic lupus erythematosus (SLE).

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Appendicitis in Children: Does Age Really Matter?

Afr J Paediatr Surg

September 2024

Department of Visceral and Urological Pediatric Surgery "A", Mohammed VI University Hospital, Oujda, Morocco.

Article Synopsis
  • Acute appendicitis (AA) is a serious stomach problem that affects children, especially those under 5 years old.
  • A study looked at 402 kids with AA and found that younger kids often show different symptoms like fever and more pain than older kids.
  • The younger kids also had more severe cases, with a higher chance of their appendix bursting compared to the older ones, making it harder to diagnose them quickly.
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A thyroid nodule is managed according to the clinical context, ultrasound (US) findings, and fine needle aspiration (FNA) results. Most thyroid nodules are benign; however, nodule classification is crucial to avoid unnecessary thyroid surgery. We conducted this study to compare the findings of fine-needle aspiration cytology (FNAC) expressed using the Bethesda system with the features of thyroid US classified using the EU-TIRADS classification to assess the risk of malignancy.

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Article Synopsis
  • HTG-AP hospitalizations are on the rise in the US, particularly affecting Hispanic patients more than non-Hispanic whites, with both groups experiencing increased hospitalization rates.
  • The study analyzed data from the National Inpatient Sample from 2016 to 2020, finding that HTG-AP accounted for 5.9% of all acute pancreatitis cases, with significantly higher rates in the Hispanic population.
  • Despite similar clinical outcomes between the groups, Hispanic patients faced substantially higher hospital costs, totaling an excess of over $26 million compared to their non-Hispanic white counterparts.
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Article Synopsis
  • * Dienogest (DNG), a selective progestin, is commonly used for treating adenomyosis, but a specific case raised concerns about its safety.
  • * A 42-year-old woman on dienogest therapy suffered from dangerous uterine bleeding leading to hemorrhagic shock and a pulmonary embolism, ultimately requiring emergency surgery and anticoagulation treatment, suggesting a link between her condition, the medication, and the complications.
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