3 results match your criteria: "Clinical Research Center of Clifford Hospital[Affiliation]"
CD27 is not an ideal marker for human memory B cells and can be modulated by IL-21 upon stimulated by Anti-CD40.
Sci Rep
October 2024
Clinical Research Center of Clifford Hospital, Guangzhou, People's Republic of China.
Article Synopsis
- B cells are crucial for the immune response as they produce antibodies, and there's ongoing research into their development, but results vary due to different species and methods used in studies.
- The current research focuses on characterizing B cells from human sources, identifying that around 50% of IgG-producing B cells in blood and up to 90% in tonsils are "atypical" memory B cells.
- The study also explored how cytokines IL-21 and TGF-β1 affect the production and expression of antibodies on B cells, revealing significant differences in their effects.
Unlike T cells in other tissues, uterine T cells must balance strong immune defense against pathogens with tolerance to semiallogeneic fetus. Our previous study fully elucidated the characteristics of T cells in nonpregnant uterus and the mechanism modulated by estrogen. However, comprehensive knowledge of the immunological properties of T (including CD4T cells and CD8T) cells in nonpregnancy uterus has not been acquired.
View Article and Find Full Text PDFTissue resident memory T cells are enriched and dysfunctional in effusion of patients with malignant tumor.
J Cancer
May 2023
Academician Workstation, Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, P.R. China.
Most malignant effusion is secondary to metastases to the pleura or peritoneum and portend poor oncological outcomes. Malignant effusion has different tumor microenvironment from primary tumor, containing a variety of cytokines and immune cells and directly contacting with tumor cells. However, the characteristic of CD4 T cells and CD8 T cells in malignant effusion remains unclear.
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