The potential role of synthetic computed tomography in spinal surgery: generation, applications, and implications for future clinical practice.

Computed tomography (CT) is widely used for the diagnosis and surgical treatment of spinal pathologies, particularly for pedicle screw placement. However, CT's limitations, notably radiation exposure, necessitate the development of alternative imaging techniques. Synthetic CT (sCT), which generates CT-like images from existing magnetic resonance imaging (MRI) scans, offers a promising alternative to reduce radiation exposure.

Can unilateral-transforaminal lumbar interbody fusion replace the traditional transforaminal lumbar interbody fusion procedure for lumbar degenerative disc diseases?: a single center matched case-control mid-term outcome study.

Study Design: Matched case-control study.

Purpose: To evaluate the midterm outcomes of unilateral pedicle screw fixation (UPSF) versus bilateral pedicle screw fixation (BPSF) in transforaminal lumbar interbody fusion (TLIF) procedure, ascertain efficacy of UPSF in adequately decompressing contralateral foramen+spinal canal and reducing rate of adjacent segment degeneration (ASD) at 4-8-year follow-up (FU).

Overview Of Literature: Previous meta-analyses found no significant differences between UPSF and BPSF regarding fusion rates, clinical and radiological outcomes; however, few studies have reported higher rates of cage migration/subsidence and pseudoarthrosis in the UPSF.

Comparison of en-bloc direct vertebrae rotation and non-direct vertebrae rotation for the correction of adolescent idiopathic scoliosis Lenke 5C: a retrospective study in Changsha, China.

Study Design: A retrospective study.

Purpose: This study aimed to compare the clinical effectiveness of en-bloc direct vertebrae rotation (DVR) to non-DVR for the correction of Lenke 5C.

Overview Of Literature: The primary goal of posterior correction is to preserve the lumbar spine and achieve a well-balanced spine.

Identifying and Understanding Seizure Liability in Drug Development.

Seizures are complex electrophysiological disturbances affecting one or more populations of brain neurons. Seizures following test article (TA) exposure pose significant challenges in drug development. This paper considers the diverse neurological manifestations, mechanisms, and functional and structural assessments needed to investigate TA-related seizure liabilities, with a particular focus on nonclinical species.

A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia ().

The study's objective is to conduct a comprehensive systematic review for assessing the safety and efficacy of Ayurvedic interventions in managing hemiplegia/Pakshaghata. The study involved a search across multiple online databases and online clinical trial registries. Additionally, major Ayurveda postgraduate institutes were contacted to acquire unpublished trial data related to hemiplegia/Pakshaghata.

Properties of New Partially Crystallized Lithium Disilicate CAD-CAM Materials.

Objective: The purpose of this study was to compare the optical, mechanical, and biological properties of two new, inexpensive lithium disilicate (LS2) materials (Lodden (LOD), LD Medical Technology; and BeautyZir (BZ), BeautyZir Technology) to a clinically established LS2 material (IPS e.max CAD (EMAX), Ivoclar Vivadent).

Methods And Materials: The optical properties of the translucency parameter (TP) and opalescence parameter (OP) were obtained with a dental spectrophotometer.

Ventricular Septal Rupture as a Complication of Acute Myocardial Infarction: Clinical Characteristics and Prognostic Comparison of Different Treatment Methods.

Background: This research aimed to investigate the clinical features exhibited by individuals diagnosed with acute myocardial infarction (AMI) complicated by ventricular septal rupture (VSR) and to compare the prognostic outcomes of different treatment modalities.

Methods: A retrospective study on a cohort of 200 patients who were diagnosed with AMI complicated by VSR at a specialized medical facility from 2018 to 2023 was conducted. The patients were categorized into 3 different treatment groups: group A received medical management, group B underwent surgical repair, and group C underwent percutaneous device closure.

Transcatheter Aortic Valve-in-Valve Implantation with Newer Generation Evolut Valve by Size of Failed Bioprosthesis.

Background: To evaluate the clinical outcomes of valve-in-valve transcatheter aortic valve replacement (ViV TAVR) with newer-generation self-expanding Evolut valves according to the size of the failed surgical bioprosthesis.

Methods: This single-center retrospective study evaluated consecutive patients undergoing ViV TAVR with the Evolut Pro/Pro+/Fx between 2018 and 2022. These patients were compared based on the true internal diameter (ID) of the failed bioprosthesis, specifically ≤19 mm (small group) vs.

Expert Consensus on Developing Information and Communication Technology-Based Patient Education Guidelines for Rheumatic Diseases in the Korea.

Background: This study aimed to identify key priorities for the development of guidelines for information and communication technology (ICT)-based patient education tailored to the needs of patients with rheumatic diseases (RDs) in the Republic of Korea, based on expert consensus.

Methods: A two-round modified Delphi study was conducted with 20 rheumatology, patient education, and digital health literacy experts. A total of 35 items covering 7 domains and 18 subdomains were evaluated.

Gaps and Similarities in Research Use LOINC Codes Utilized in Korean University Hospitals: Towards Semantic Interoperability for Patient Care.

Background: The accuracy of Logical Observation Identifiers Names and Codes (LOINC) mappings is reportedly low, and the LOINC codes used for research purposes in Korea have not been validated for accuracy or usability. Our study aimed to evaluate the discrepancies and similarities in interoperability using existing LOINC mappings in actual patient care settings.

Methods: We collected data on local test codes and their corresponding LOINC mappings from seven university hospitals.

A-to-I-Edited miR-1304-3p Inhibits Glycolysis and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inactivating Wnt5a/ROR2 Signaling.

A-to-I RNA editing is a pervasive mechanism in the human genome that affects the regulation of gene expression and is closely associated with the pathogenesis of numerous diseases. This study elucidates the regulatory mechanism of A-to-I edited miR-1304-3p in esophageal squamous cell carcinoma (ESCC). Western blot, immunohistochemistry, and RT-qPCR assays were employed to quantify protein and mRNA expression.

Effect of Superficial Large Vessel Insulation Combined with Self-heating Warm Paste on Intraoperative Hypothermia in Patients Undergoing Urologic Surgery.

Objective: This study aimed to explore the application effect of superficial large vessel insulation combined with self-heating warm paste on intraoperative hypothermia in patients undergoing urologic surgery.

Methods: This study included 313 patients who underwent urologic surgery in Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University from May 2023 to March 2024. After 13 patients with incomplete clinical data, abnormal basal metabolism and preoperative skin injury were excluded, 300 patients were finally included.

Immunotherapy in Penile Cancer: A Systematic Review.

Penile cancer (PeCa) ranks as the 30th most prevalent cancer globally, predominantly affecting populations in developing countries. Phimosis and Human Papillomavirus (HPV) infection are recognized as the primary risk factors. Early-stage diagnosis typically warrants limited excision or non-invasive therapies.

Association between laboratory data-based frailty index and clinical health outcomes in critically ill older patients: A retrospective correlational study.

Background: Although frailty assessment is crucial for understanding critically ill patients' prognosis, traditional frailty measures require substantial efforts and time from health care professionals. To address this limitation, the laboratory frailty index (FI-LAB) based on laboratory clinical data was developed. However, knowledge regarding its correlation with health outcomes among critically ill older patients is limited.

The 2023 fatal dengue outbreak in Bangladesh highlights a paradigm shift of geographical distribution of cases.

In 2023, Bangladesh experienced its largest and deadliest outbreak of the Dengue virus (DENV), reporting the highest-ever recorded annual cases and deaths. Historically, most of the cases were recorded in the capital city, Dhaka. We aimed to characterize the geographical transmission of DENV in Bangladesh.

Clinical pharmacology and pharmaceutical medicine - creation of a new specialist title for physicians in Belgium.

Belgium has a vibrant health eco-system, with world-class universities and hospitals, and a strong presence of pharmaceutical companies, resulting in a substantial contribution to drug development and a high number of clinical trials. Talent development is pivotal for further growth of this eco-system and to attract future professionals. Although physicians play an important role in this complex eco-system, with an estimated 400-450 Belgian physicians presently active in the field of the drug life cycle, Pharmaceutical Medicine and Clinical Pharmacology were not recognized as a speciality in Belgium until recently.

Commentary on the Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety and Related Disorders: Evidence-Based Treatments Require Appropriate Systems of Care to Be Implemented.

Plain Language Summary Key points about the CANMAT perinatal guidelines are commented on. The process of developing the guidelines was robust and there can be a high level of confidence in their recommendations. An important aspect is that services for women with perinatal mood and anxiety disorders need to put in place so that the range on evidence based treatments can be implemented.

Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune Thrombocytopenia.

Objectives: To explore the risk factors for thrombi occurring in patients with immune thrombocytopenia (ITP) and establish a risk prediction model to better predict the risk of thrombosis in patients with ITP.

Methods: We retrospectively analyzed 350 ITP patients who had been hospitalized in the First People's Hospital of Yunnan Province between January 2024 and June 2024. For all patients, we recorded demographic characteristics and clinical data, analyzed the risk factors for thrombosis in ITP patients and then developed a risk prediction model.

Evidence-based Interventions for Youth With Concurrent Mental Health and Substance Use Disorders: A Scoping Review: Interventions fondées sur des données probantes pour les jeunes atteints de troubles concomitants de santé mentale et liés à l'usage de substances psychoactives : une étude de la portée.

Background: Mental health and substance use disorders typically onset during youth and commonly co-occur. Integrated treatment of two or more co-existing mental health and substance use disorders (i.e.

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Background: Although self-esteem is a relatively new concept, first developed in the field of social psychology, it has gained increasing importance in psychiatry, especially as a diagnostic criterion. However, it is poorly evaluated in clinical practice. The lack of an instrument allowing an easy global assessment may be the reason for this.

Machine perfusion organ preservation: Highlights from the American transplant congress 2024.

The American Transplant Congress (ATC) 2024, held in Philadelphia, serves as a vital platform for unveiling new research and clinical experience in organ machine perfusion-a key area in organ transplantation. This year's congress gathered 4652 participants from 49 countries, including top experts, to spotlight innovations in machine perfusion across various organ types, such as the liver, kidney, heart, and lung. A total of 87 abstracts on organ machine perfusion were presented.

Non-pharmacological Interventions for Preoperative Anxiety in Children: A Systematic Review and Network Meta-Analysis.

Aims: This study aimed to compare the efficacy of non-pharmacological interventions in children with preoperative anxiety.

Background: It is estimated that preoperative anxiety affects up to 60% of children which is associated with both immediate and long-term adverse outcomes. Several non-pharmacological interventions have been demonstrated to be effective, but further research is necessary to determine which is the most effective.

Prospective Study of lncRNA NORAD for Predicting Cerebrovascular Events in Asymptomatic Patients with Carotid Artery Stenosis.

Background: Carotid artery stenosis (CAS) may cause many cerebrovascular diseases, and a biomarker for screening and monitoring is needed. This study focused on the clinical significance of long-chain non-coding RNA (lncRNA) non-coding RNA activated by DNA damage (NORAD) in patients with CAS and aimed to search for potential biomarkers of CAS.

Methods: Eighty-six asymptomatic patients with CAS and 60 healthy individuals were enrolled, with corresponding clinical data and serum samples collected.