Exploring nagZ as a virulence biomarker and treatment target in Enterobacter cloacae.

Background: Enterobacter cloacae is increasingly prevalent and resistant to multiple antibiotics, making it a significant pathogen in healthcare settings with high mortality rates. However, its pathogenic mechanisms are not fully understood.

Results: In this study, we explored the role of nagZ in regulating the virulence of E.

The risk factors and prediction model for postoperative pneumonia after craniotomy.

Background: Craniotomy is highly susceptible to postoperative pneumonia, which significantly impacts the outcomes of patients undergoing such procedures. Our study aims to examine the risk factors associated with postoperative pneumonia and establish a predictive model with a nomogram to assess this risk.

Methods: We conducted a matched 1:1 case-control study involving 831 adult patients undergoing craniotomy at our hospital.

Thiostrepton suppresses colorectal cancer progression through reactive oxygen species related endoplasmic reticulum stress.

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Due to the poor therapeutic efficacy of CRC treatments and poor prognosis of the disease, effective treatment strategies are urgently needed. As long-term proteotoxic stress is a major cause of cell death, agents that induce proteotoxic stress offer a promising strategy for cancer intervention.

Development and validation of interpretable machine learning models for postoperative pneumonia prediction.

Background: Postoperative pneumonia, a prevalent form of hospital-acquired pneumonia, poses significant risks to patients' prognosis and even their lives. This study aimed to develop and validate a predictive model for postoperative pneumonia in surgical patients using nine machine learning methods.

Objective: Our study aims to develop and validate a predictive model for POP in surgical patients using nine machine learning algorithms.

Predicting postoperative pulmonary infection risk in patients with diabetes using machine learning.

Background: Patients with diabetes face an increased risk of postoperative pulmonary infection (PPI). However, precise predictive models specific to this patient group are lacking.

Objective: To develop and validate a machine learning model for predicting PPI risk in patients with diabetes.

Serum pentraxin-3 as a potential biomarker for diagnosis and prognosis in primary liver cancer: An observational study.

This study aimed to examine serum pentraxin 3 levels in patients with primary liver cancer and to assess its potential as a diagnostic and prognostic biomarker. Serum samples were obtained from 180 patients with primary liver cancer and 180 healthy control subjects. The concentration of PTX3 in these samples was measured using an ELISA kit.

Development of a novel difficulty scoring system for laparoscopic liver resection procedure in patients with intrahepatic duct stones.

Background: For intrahepatic duct (IHD) stones, laparoscopic liver resection (LLR) is currently a reliable treatment. However, the current LLR difficulty scoring system (DSS) is only available for patients with hepatocellular carcinoma.

Aim: To explore the development of a DSS for IHD stone patients with LLR and the validation of its reliability.

Clinical and prognostic significance of Hec1 expression in patients with Cervical Cancer.

Objective: Hec1 is a component of the Ndc80 kinetochore complex and is frequently upregulated in various cancers. However, the clinical significance of Hec1 in cervical cancer remains largely unknown. This study aimed to investigate the expression patterns of Hec1 in cervical cancer and its relationship with the clinicopathological characteristics of patients diagnosed with the disease.

Clinical effectiveness and safety of preoperative oral carbohydrate loading in patients with diabetes: A systematic review.

Background: The effectiveness and safety of preoperative oral carbohydrate (POC) for people with diabetes remain controversial.

Methods: We systematically reviewed studies comparing POC to fasting or placebo in elective surgery for diabetic adults, focusing on gastric volume, postoperative complications, hospital stay, and glycemic control.

Results: Fourteen studies (n = 1870 patients) were included.

Associations between obstructive sleep apnea risk and urinary incontinence: Insights from a nationally representative survey.

Obstructive sleep apnea (OSA) and urinary incontinence (UI) are two prevalent health conditions with significant impacts on individuals' quality of life. Although they appear distinct in nature, a growing body of evidence suggests a potential interrelationship between these conditions. Our objective was to explore the association between the risk of OSA and the occurrence of UI within a nationally representative sample of U.

Rhoifolin Attenuates Concanavalin A-Induced Autoimmune Hepatitis in Mice via JAKs/STATs Mediated Immune and Apoptotic Processes.

Rhoifolin (ROF) exhibits a diverse range of biological activities, encompassing anticancer, hepatoprotective, antidiabetic, antirheumatic, and antiviral properties. However, the specific protective effects and possible mechanisms of the compound against T-cell-mediated autoimmune hepatitis have not been previously elucidated. In the present study, adult male mice were administered Con A (20 mg/kg, intravenously) for 8 h.

Prognosis in HR-positive metastatic breast cancer with HER2-low versus HER2-zero treated with CDK4/6 inhibitor and endocrine therapy: a meta-analysis.

Background: The combination of CDK4/6 inhibitors (CDK4/6i) and endocrine therapy (ET) is currently the standard first-line treatment for patients with metastatic hormone receptor positive (HR+), and HER2-negative (HER2-) breast cancer. However, the impact of HER2 status on the prognosis of patients receiving CDK4/6i and ET remains unclear. The meta-analysis was conducted to evaluate different outcomes between HER2-low and HER2-zero patients in advanced HR+ breast cancer receiving CDK4/6i and ET.

Chemerin 15 peptide reduces neuroinflammation via the ChemR23 receptor after ischemia-reperfusion injury.

Microglia-mediated neuroinflammation plays a crucial role in ischemic stroke; consequently, understanding its regulation could facilitate the development of therapies for ischemic stroke. Chemerin 15, a 15-amino acid peptide derived from chemerin, exerts powerful anti-inflammatory effects through ChemR23, modulates macrophage polarization, and diminishes inflammatory cytokine expression in peripheral inflammation models. However, its effects on microglia and stroke remain unclear.

Process Evaluation of an Ambulance-Delivered Early Intensive Blood Pressure-Lowering Stroke Trial: Design, Rationale, and Reflection.

Introduction: The fourth INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4) is a large-scale, multicenter, prospective, randomized, open-label, blinded endpoint assessment trial, initiated in an ambulance in China, aiming at evaluating the effectiveness and safety of prehospital blood pressure (BP) lowering in patients with suspected acute stroke and elevated BP. A prespecified process evaluation is intended to explore the implementation of the trial intervention, provide support to interpret the trial outcomes and put forward suggestions to scale up the intervention in broader settings in the future.

Methods: This process evaluation is a mixed-methods design, and follows the Normalization Process Theory (NPT) and the UK Medical Research Council (UK MRC) guidance.

Natural killer cells: a future star for immunotherapy of head and neck squamous cell carcinoma.

The interplay between immune components and the epithelium plays a crucial role in the development and progression of head and neck squamous cell carcinoma (HNSCC). Natural killer (NK) cells, one of the main tumor-killing immune cell populations, have received increasing attention in HNSCC immunotherapy. In this review, we explore the mechanism underlying the interplay between NK cells and HNSCC.

The effect of perineural dexamethasone on nerve injury and recovery of nerve function after surgery: A randomized controlled trial.

Background: While numerous studies have examined the influence of perineural dexamethasone on nerve block duration, its potential impact on postoperative nerve injury has not been adequately addressed.

Objective: This study aims to elucidate the effect of perineural dexamethasone on nerve injury and nerve function recovery after surgery.

Design: A prospective randomized double-blinded trial.