Glucocorticoid regulation of the mTORC1 pathway modulates CD4 T cell responses during infection.

Objectives: Conventional glucocorticoid (GC) treatment poses significant risks for opportunistic infections due to its suppressive impact on CD4 T cells. This study aimed to explore the mechanisms by which GCs modulate the functionality of CD4 T cells during infection.

Methods: We consistently measured FOXP3, inflammatory cytokines and phospho-S6 ribosomal protein levels in CD4 T cells from patients undergoing conventional GC treatment.