1 results match your criteria: "Clinical Imaging Centre Hammersmith Hospital[Affiliation]"
Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A.
Nucl Med Biol
August 2011
GlaxoSmithKline, Clinical Imaging Centre Hammersmith Hospital, London, W12 0NN, UK.
Article Synopsis
- The study aimed to assess a new PET radioligand, [(11)C]MP-10, which targets the PDE10A enzyme in the brain.
- The research involved labeling MP-10 with carbon-11 and conducting PET imaging in pig and baboon brains, revealing that [(11)C]MP-10 rapidly penetrated the brain in pigs and had a slower uptake in nonhuman primates.
- The findings confirmed that [(11)C]MP-10 demonstrated selectivity and suitability for quantifying PDE10A in vivo, with consistent regional brain binding patterns aligned with existing knowledge about PDE10A distribution.