[Efficacy of Mexidol in combination with cerebral revascularization in the treatment of ischemic stroke].

Stroke is an acute life-threatening condition; its outcome is determined by the degree of damage to brain tissue, the quality and speed of medical care in the first minutes and hours after its occurrence. The main mechanism of brain tissue damage during both ischemia and reperfusion is oxidative stress. The review covers adverse influence oxidative stress at the cerebral ischemia and reperfusion periodes of ischemic stroke.

Fluctuating asymmetry of human morphometric features as a marker of developmental instability caused by adverse environmental conditions.

Background: This article is an attempt to apply fluctuating asymmetry as amorphometric method of studying changes in specific structures of the right and the left side of the body to determine variables which may affect morphogenesis and, consequently, human morphology in adulthood. The main aim of this study was to use the fluctuating asymmetry level as an indicator of adverse living conditions in childhood by determining the impact of environmental components (socio-economic factors and air pollution) on the level of body asymmetry in young women and men.

Materials And Methods: Data were collected from 877 students from various Polish universities, including 483 women and 394 men.

[Vestibular rehabilitation for peripheral vestibular hypofunction: an interdisciplinary consensus].

The literature review presents approaches to the management of patients with vestibular disorders. The principles of organization of vestibular rehabilitation in peripheral vestibular hypofunction, indications for appointment, factors influencing its implementation, technique, methods of evaluating effectiveness are considered in detail. Attention is drawn to the fact that the selection of exercises and the duration of vestibular rehabilitation is carried out individually and depends on many factors, including the nature of vestibular deficiency and the specific characteristics of the patient.

Mathematical modeling in assessing the risk of restenosis after carotid endarterectomy.

Carotid endarterectomy is the main way to combat atherosclerosis of the carotid arteries, which disrupts cerebral circulation. The generally accepted marker of atherogenesis risk are hemodynamic indices associated with near-wall shear stress. The purpose of the work is to conduct a comparative analysis of hemodynamic indices in various carotid bifurcation models.

Diagnosis and Treatment Patterns of Chronic Thromboembolic Pulmonary Hypertension in Russia, Kazakhstan, Turkey, Lebanon, and Saudi Arabia: A Registry Study.

Background: Patients with chronic thromboembolic pulmonary hypertension (CTEPH) in countries with limited resources have, to date, been poorly represented in registries.

Objective: This work assesses the epidemiology, diagnosis, hemodynamic and functional parameters, and treatment of CTEPH in Russia, Kazakhstan, Turkey, Lebanon, and Saudi Arabia.

Methods: A prospective, cohort, phase IV, observational registry with 3-year follow-up (n = 212) in patients aged ≥ 18 years diagnosed with CTEPH was created.

[Russian study on brain aneurysm surgery: a continuation (RIHA II)].

Objective: To assess the main performance indicators of neurosurgical departments in surgical treatment of cerebral aneurysms in the Russian Federation.

Material And Methods: We analyzed 22 neurosurgical departments (19 regional and 3 federal hospitals) in 2017 and 2021. The study enrolled 6.

[Improving surgical technique for tracheal resection with anastomosis].

Objective: To present modern aspects of improving surgical techniques in tracheal resection developed in recent years.

Material And Methods: The authors have the most extensive experience in tracheal surgery (>2.000 patients over the past 50 years).

Mechanical Properties of V-O-N Coatings Synthesized by Cathodic Arc Evaporation.

The V-O-N coating set was produced at different relative oxygen concentrations of O(x) = O/(N +O) using cathodic arc evaporation. The aim of the research was to determine the effect of oxygen on coating properties. The coatings' composition and structural properties (X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX)) and mechanical properties-hardness, adhesion, and wear resistance (nano-indenter, scratch tester, ball-on-disc tester)-were extensively investigated.

Blood Pressure Response and Symptoms During Active Standing Test Among Hospitalized and Outpatients With Heart Failure: Results From the GRAVITY-HF Prospective Observational Cohort Study.

Background: We conducted a multicenter, prospective, observational study to describe the incidence of orthostatic hypotension (OH) and orthostatic hypertension (OHtn) and its association with symptoms at standing and outcomes in patients with heart failure (HF).

Methods And Results: 321 active standing tests were performed in 87 inpatients during admission, and 316 tests were performed in 208 outpatients during follow-up. Blood pressure (BP) was measured by an automatic device 4 times in the supine position and at 1, 3 and 5 minutes of standing.

[Obstructive uropathia in pregnant women: results of treatment depending on the etiopatogenetic factor of development].

Unlabelled: Actuality. The development of renal colic in pregnant women is one of the most common reasons for visiting a hospital that is not associated with obstetric pathology. Given the pharmacological and diagnostic limitations during gestation, the problem of expanding the renal cavitary system in pregnant women, as well as the choice of treatment tactics, remains a difficult clinical task.

Prediction of Hospital Mortality in Patients with ST Segment Elevation Myocardial Infarction: Evolution of Risk Measurement Techniques and Assessment of Their Effectiveness (Review).

Risk stratification of hospital mortality in patients with ST segment elevation myocardial infarction on the electrocardiogram is an important part of the specialized medical care provision. The systematic review presents scientific literature data characterizing the predictive value of both classical prognostic scales (GRACE, CADDILLAC, TIMI risk score for STEMI, RECORD, etc.) and new risk measurement tools developed on the basis of modern machine learning techniques.

Osteoprotegerin Gene as a Biomarker in the Development of Osteoporosis in Postmenopausal Women.

Osteoporosis is a multifactorial and polygenic disease caused by an imbalance between osteoclastogenesis and osteoblastogenesis, leading to a decrease in bone mineral density and the occurrence of disorders in the microarchitecture and metabolism of bone tissue. In postmenopausal women, there is a significant decrease in the production of estrogens, which play a key role in maintaining proper bone mineral density. Estrogens have an inhibitory effect on the development and activity of osteoclasts by reducing the synthesis of pro-resorption cytokines and stimulating the expression of osteoprotegerin (OPG).

[Psychosocial pathomorphosis of depressions].

Objective: The aim is to determine the changes in phenomenology of depressions (mostly of melancholic type with pronounced affect of sadness, chronobiological shift, neurovegetative changes and typical affect-congruent depressive ideas) over the past decades.

Material And Methods: We've compared the archival data of one of the authors (V.N.

[Total replacement of both carotid arteries combined with ascending aorta and aortic arch replacement for acute DeBakey type I aortic dissection].

Involvement of supra-aortic vessels into acute DeBakey type I aortic dissection is a significant predictor of adverse postoperative neurological outcomes and mortality. The choice of surgical tactics remains open in such patients. We present total replacement of both common carotid arteries and proximal part of the right subclavian artery with reconstruction of ascending aorta and aortic arch for acute DeBakey type I dissection.

[Clinical and economic aspects of laparoscopic surgery for acute cholecystitis in delayed presentation].

Objective: To study the clinical and economic features of laparoscopic surgery for acute cholecystitis in delayed presentation.

Material And Methods: A prospective non-randomized study (2020-2021) included 101 patients (73.2% (=74) men and 26.

[THE STATUS OF THE SERVICE OF MEDICAL STATISTICS ACCORDING TO THE STAFF SURVEY RESULTS].

Inroduction: The Medical Statistics Service plays an important role in providing a medical organization with timely, high-quality statistical information. Therefore, it is important to study the opinions of specialists on the organization of this work.

Purpose: To analyze the opinions of the staff of departments (offices) of medical statistics on the current work organization.

Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio in ADHD: a systematic review and meta-analysis.

Introduction: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an unclear etiology. Systemic inflammation and immune dysregulation may play a role in the pathogenesis of ADHD. Morphology-derived parameters such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR), have been proposed as peripheral biomarkers of the immune-inflammatory process in various diseases.

Analysis of , , , , , and Gene Expression Levels in Peripheral Blood of Patients with Early Stages of Parkinson's Disease.

Parkinson's disease (PD) is a common chronic, age-related neurodegenerative disease. This disease is characterized by a long prodromal period. In this context, it is important to search for the genes and mechanisms that are involved in the development of the pathological process in the earliest stages of the disease.

[Living related liver transplantation in the Republic of Uzbekistan: current status and development prospects].

Objective: To analyze primary results of living related liver transplantation in the Republic of Uzbekistan.

Material And Methods: There were 44 living related transplantations of the right liver lobe in patients with decompensated liver failure between February 2018 and February 2023.

Results: Uneventful postoperative period was observed in 17 (38.

Analysis of the Polymorphisms and Expression Levels of the BCL2, BAX and c-MYC Genes in Patients with Ovarian Cancer.

Ovarian cancer (OC) is one of the biggest problems in gynecological oncology and is one of the most lethal cancers in women worldwide. Most patients with OC are diagnosed at an advanced stage; therefore, there is an urgent need to find new biomarkers for this disease. Gene expression profiling is proving to be a very effective tool for exploring new molecular markers for OC patients, although the relationship between such markers and patient survival and clinical outcomes is still elusive.

[Methods of surgical treatment for isolated lesions of the sphenoid sinus].

This article presents an analytical review of scientific publications on the topic of surgical treatment of isolated lesions of the sphenoid sinus. The publications, research data presented in the RSCI database, PubMed in the period 1985-2021 are analyzed. The selection of the material was carried out according to the keywords: sphenoid sinus, isolated sphenoiditis, phenotypes of sphenoiditis, endoscopic sphenotomy, relapses of sphenoiditis, sphenoid sinus, isolated sphenoiditis, phenotypes of sphenoiditis.

[Local fibrinolisis in nontraumatic intraventricular hemorrhages].

The management of patients with hemorrhagic stroke is an important problem in modern neurology and neurosurgery. The proportion of hemorrhagic stroke is only 15% of all cases of acute cerebrovascular accident, but mortality reaches 50% (and with intraventricular hemorrhages up to 80%), and disability is over 75%. Minimally invasive methods are being developed to reduce intraoperative damage to brain and improve the prognosis for the patient.

Larval Wound Therapy: Possibilities and Potential Limitations-A Literature Review.

Patient-centered care (PCC) is recognized as a standard in healthcare for determining high quality. Honoring patients' values, experiences, needs, and preferences in devising, coordinating, and delivering care underscores the enhancement of the therapeutic rapport between patients and healthcare providers. Wound treatment involves a multi-stage process encompassing diagnostics and local wound dressing, which reduces the risk of infection through a coordinated interdisciplinary team.

Multimodal Diagnostics of Changes in Rat Lungs after Vaping.

(1) Background: The use of electronic cigarettes has become widespread in recent years. The use of e-cigarettes leads to milder pathological conditions compared to traditional cigarette smoking. Nevertheless, e-liquid vaping can cause morphological changes in lung tissue, which affects and impairs gas exchange.