12 results match your criteria: "Clinical Evidence Research[Affiliation]"

[Guideline for Minimizing Radiation Exposure of Interventionalists during Fluoroscopy-guided Interventional Procedures].

Korean J Gastroenterol

December 2024

Division of Healthcare Research, Clinical Evidence Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea.

As fluoroscopy-guided interventional procedures gain popularity, the associated health threats from radiation exposure to interventionalists during these procedures are increasing. Therefore, an understanding of the potential risks of radiation and careful consideration on minimizing exposure to radiation during the procedures are of paramount importance. The Korean Pancreatobiliary Association has developed a clinical practice guideline to minimize radiation exposure during fluoroscopy-guided interventional procedures.

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Backgrounds/aims: This meta-analysis examined whether preoperative vibration-controlled transient elastography (VCTE) can predict postoperative complications and recurrence in patients undergoing hepatic resection for hepatocellular carcinoma (HCC).

Methods: A systematic literature search was conducted using Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases. Out of 431 individual studies, thirteen published between 2008 and 2022 were included.

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Article Synopsis
  • - The Fibrosis-4 index (FIB-4) is a noninvasive test used to assess advanced liver fibrosis (AF) in patients with nonalcoholic fatty liver disease (NAFLD), though its effectiveness in those with type 2 diabetes mellitus (T2DM) is debated due to high AF rates in this group.
  • - A meta-analysis of 12 studies involving 5,624 NAFLD patients with T2DM revealed that FIB-4 has moderate sensitivity and specificity, particularly showing better performance at high cutoffs (high specificity but lower sensitivity).
  • - While FIB-4 can be useful for diagnosing AF, the current evidence is limited and varied, suggesting a need for more research to
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Article Synopsis
  • Childhood obesity is linked to a rising prevalence of nonalcoholic fatty liver disease (NAFLD) in kids and teens, yet systematic studies on this issue are scarce.
  • A comprehensive search of multiple databases yielded 62 relevant studies for analysis, revealing that NAFLD affects 13% of the general pediatric population and 47% of obese kids.
  • The study found significant gender differences in prevalence, with higher rates in males than females for both general and obese populations, highlighting the urgent need for more epidemiological research on NAFLD in pediatrics.
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Aims: Influenza remains a contributor to substantial global morbidity and mortality. There is very limited data on disease burden in Egypt. The purpose of this study was to estimate the incidence of influenza-associated Severe Acute Respiratory Illness (SARI) in three districts in Gharbia governorate in 2018.

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Article Synopsis
  • The study analyzed the effectiveness of anabolic agents versus bisphosphonates in preventing new osteoporotic vertebral fractures (OVF) and aiding in fracture healing among patients with existing OVF, using meta-analysis of randomized controlled trials (RCTs).
  • After screening 518 studies, only 6 RCTs met the criteria, revealing that anabolic agents like teriparatide and romosozumab significantly reduced the risk of new OVF compared to bisphosphonates, with high-certainty evidence for this finding.
  • While anabolic agents were effective in preventing new fractures, there was no significant difference in the healing of existing fractures when comparing teriparatide with alendronate
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Author`s reply: Effect of exercise-based interventions in nonalcoholic fatty liver disease: A systematic review with meta-analysis.

Dig Liver Dis

November 2023

Clinical Evidence Research, Division of Health Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency, Seoul 04933, Republic of Korea. Electronic address:

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Effect of exercise-based interventions in nonalcoholic fatty liver disease: A systematic review with meta-analysis.

Dig Liver Dis

September 2023

Clinical Evidence Research, National Evidence-based Healthcare Collaborating Agency, Seoul, 04933, Republic of Korea. Electronic address:

Background: The global burden of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing.

Aims: This study aimed to evaluate the effect of exercise on intrahepatic lipid (IHL), serum alanine aminotransferase (ALT), body mass index (BMI), and insulin resistance in NAFLD patients.

Methods: We searched MEDLINE, Embase, Cochrane CENTRAL, KMbase, and the Korean Studies Information Service System through April 2022.

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Background/aims: Several noninvasive scoring systems have been developed to determine the risk of advanced fibrosis in nonalcoholic fatty liver disease (NAFLD). We examined the diagnostic accuracy of the fibrosis-4 (FIB-4) score and NAFLD fibrosis score (NFS) in patients with biopsy-proven NAFLD.

Methods: For this meta-analysis, various databases including PubMed (MEDLINE), EMBASE, OVID Medline and the Cochrane Library were systematically searched.

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Purpose: To assess the CT diagnostic performance for evaluating resectability of pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant therapy and identify the factor(s) that affect(s) diagnostic performance.

Methods: Databases were searched to identify studies published from January 1, 2000, to November 5, 2019 that evaluated the CT diagnostic performance for assessing resectability of post-neoadjuvant PDAC. Two reviewers independently extracted data and assessed the study quality.

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Adverse events following implantable cardioverter defibrillator implantation: a systematic review.

J Interv Card Electrophysiol

August 2014

Center for Clinical Evidence Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.

Article Synopsis
  • Implantable cardioverter defibrillators (ICDs) are effective for preventing sudden cardiac death, but patients should be informed about potential adverse events associated with their use.
  • A review of studies identified low rates of serious adverse events during hospitalization (2.8-3.6%) and variable rates of long-term complications after ICD implantation, but the quality of evidence for these long-term effects was low.
  • Up to 21% of patients may experience inappropriate shocks from the device, highlighting the importance of patient counseling about risks involved.
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