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Which Patients with Giant Cell Arteritis Will Develop Cardiovascular or Cerebrovascular Disease? A Clinical Practice Research Datalink Study.
J Rheumatol
June 2016
From the Faculty of Health and Applied Sciences, University of the West of England; School of Clinical Sciences at South Bristol, University of Bristol; Rheumatology, University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Rheumatology Department, Nuffield Orthopaedic Centre, Oxford; Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton; Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine Room; Clinical Effectiveness Unit, The Royal College of Surgeons of England, London; Southend University Hospital NHS Trust, Essex; University of Exeter Medical School, Exeter, UK.J.C. Robson, MBBS, PhD, MRCP, Consultant Senior Lecturer in Rheumatology, Faculty of Health and Applied Sciences, University of the West of England, Bristol, and Honorary Senior Lecturer, School of Clinical Sciences at South Bristol, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A. Kiran, PhD, Statistician, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Nuffield Orthopaedic Centre; J. Maskell, BSc, Data Manager, Faculty of Medicine, University of Southampton, Southampton General Hospital; A. Hutchings, MSc, Lecturer, Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine Room; N. Arden, MBBS, FRCP, MSc, MD, Professor of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Nuffield Orthopaedic Centre; B. Dasgupta, MBBS, MD, FRCP, Professor of Rheumatology, Southend University Hospital NHS Trust; W. Hamilton, MD, FRCP, FRCGP, Professor of Primary Care Diagnostics, University of Exeter Medical School; A. Emin, BSc, MSc, MBBS, MRCS, UK Cardiothoracic Transplant Research Fellow, Clinical Effectivene
Objective: To evaluate the risk of cerebrovascular disease and cardiovascular disease (CVD) in patients with giant cell arteritis (GCA), and to identify predictors.
Methods: The UK Clinical Practice Research Datalink 1991-2010 was used for a parallel cohort study of 5827 patients with GCA and 37,090 age-, sex-, and location-matched controls. A multivariable competing risk model (non-cerebrovascular/CV-related death as the competing risk) determined the relative risk [subhazard ratio (SHR)] between patients with GCA compared with background controls for cerebrovascular disease, CVD, or either.