13 results match your criteria: "Clinical Division of Paediatrics[Affiliation]"
Exercise-induced bronchoconstriction in adolescent recreational athletes: Potential screening strategies.
Pediatr Allergy Immunol
August 2024
Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
Article Synopsis
- Intense physical exercise in adolescents can lead to exercise-induced bronchoconstriction (EIB), which affects 22% of athletes studied, with many being unaware of their condition.
- The study involved 327 adolescent athletes who underwent various tests, revealing links between EIB, asthma history, and atopy, with many EIB athletes not using inhalation therapy.
- Effective screening methods like questionnaires and lung function tests were highlighted, emphasizing the need for better detection of EIB, particularly in athletes exposed to air pollution.
Combined Exercise and Diet Induce Airway Hyperreactivity While Reducing Liver Steatosis in Mice with Diet-Induced Obesity.
Nutrients
July 2024
KU Leuven, Department of Public Health and Primary Care, 3000 Leuven, Belgium.
Article Synopsis
- Obesity is linked to various health issues, including non-alcoholic fatty liver disease and asthma, but there is limited research on how exercise and diet affect these conditions in the context of obesity.
- In an experiment with mice, those on a high-fat diet were split into two groups: one continued on the high-fat diet while the other switched to a normal diet, with half of each group doing exercise.
- The results showed that while combining diet and exercise reduced liver fat and damage, it increased airway inflammation and sensitivity in mice, highlighting a complex relationship between weight management and respiratory health.
Validation and shortcomings of the most common mouse model of chronic rhinosinusitis with nasal polyps.
Rhinology
August 2024
Pole of Pneumology, ORL (airways) and Dermatology (skin) (LUNS), Institute of Experimental and Clinical Research (IREC), Universitat Catholique de Louvain (UCLouvain), Brussels, Belgium; Department of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Background: Chronic rhinosinusitis (CRS) is a highly prevalent airway disease worldwide. Whereas eosinophilic CRS with nasal polyps (eCRSwNP) represents its most severe phenotype, pathogenic mechanisms remain poorly understood despite a wide spectrum of in vitro and in vivo experimental models. A mouse model of experimental ovalbumin (OVA)-induced airway allergy with coadministration of Staphylococcus aureus enterotoxin B (SEB) has been widely used to study eosinophilic eCRSwNP.
View Article and Find Full Text PDFCan AQUA© questionnaire and FeNO predict atopy in early-career athletes?
Pediatr Allergy Immunol
March 2023
Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.
Activation of epithelial and inflammatory pathways in adolescent elite athletes exposed to intense exercise and air pollution.
Thorax
August 2023
Allergy and Clinical Immunology Research Group, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
Article Synopsis
- The study examines how high-intensity exercise and air pollution impact the airway barrier in adolescent elite athletes versus healthy controls.
- It involved testing 90 athletes from Flemish Elite Sports Schools and 25 control subjects for exercise-induced bronchoconstriction (EIB) using the eucapnic voluntary hyperventilation (EVH) test, alongside analyzing sputum samples for genetic and inflammatory markers.
- Results indicated that athletes had higher levels of airway inflammation and cell damage, with 9% showing EIB, suggesting that intense exercise combined with air pollution exposure can harm respiratory health.
Association between outdoor air pollution and chronic rhinosinusitis patient reported outcomes.
Environ Health
December 2022
Department of Microbiology, Allergy and Clinical Immunology Research Group, Immunology & Transplantation, Herestraat 49/811, 3000, Louvain, KU, Belgium.
Background: The aetiology of chronic rhinosinusitis (CRS) is multifactorial with a complex interplay between environmental, microbial endogenous and genetic factors. The impact of outdoor air pollution on prevalence or severity of CRS remains largely unknown.
Methods: Real-life geolocation data (2017-2018, Belgium) from 278 CRS patients (2576 health records) using the mySinusitisCoach mobile application were analysed to calculate the patients' individual exposure to outdoor air pollutants (ozone (O), black carbon (BC), nitrogen dioxide (NO) and particulate matter with diameter < 2.
Corrigendum: Innate lymphoid cells are required to induce airway hyperreactivity in a murine neutrophilic asthma model.
Front Immunol
September 2022
Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.
Article Synopsis
- The text refers to a correction made to a specific article with the DOI: 10.3389/fimmu.2022.849155, indicating that there may have been an error or oversight in the original publication.
- The correction is important for maintaining the accuracy and integrity of the scientific record related to the research presented in the article.
- Readers looking for the corrected information or updates should refer to the corrected version of the article through its DOI link.
Chlorine exposure and intensive exercise induces airway hyperreactivity in a 3-week murine exercise model.
Sci Total Environ
October 2022
KU Leuven, Department of Public Health and Primary Care, Centre for Environment and Health, Herestraat 49 box 952, 3000 Leuven, Belgium. Electronic address:
Rationale: Exercise-induced bronchoconstriction (EIB) is defined as acute narrowing of the airways during or immediately after exercise. EIB has a high prevalence in elite swimmers probably due to the high ventilation rate and exposure to the chlorine by-products. It is still puzzling which pathophysiological mechanisms drive EIB.
View Article and Find Full Text PDFInnate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model.
Front Immunol
April 2022
Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.
Rationale: Non-allergic asthma is driven by multiple endotypes of which neutrophilic and pauci-granulocytic asthma have been best established. However, it is still puzzling what drives inflammation and airway hyperreactivity (AHR) in these patients and how it can be treated effectively. Recently, a potential role of the innate immune system and especially the innate lymphoid cells (ILC) has been proposed.
View Article and Find Full Text PDFHow to detect young athletes at risk of exercise-induced bronchoconstriction?
Paediatr Respir Rev
December 2022
KU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven 3000, Belgium; UZ Leuven, Clinical Division of Paediatrics, Leuven 3000, Belgium.
Exercise-induced bronchoconstriction (EIB) is a prevalent condition in elite athletes caused by transient airway narrowing during or after exercise. Young athletes nowadays start early to perform high level exercise, highlighting the need to screen for EIB in a younger population. The purpose of this review is to evaluate current evidence of pre-tests with high probability to predict a positive provocation test in young and adolescent athletes, aged 12-24 years and thus indicate whether a young athlete is at risk of having EIB.
View Article and Find Full Text PDFEarly-onset airway damage in early-career elite athletes: A risk factor for exercise-induced bronchoconstriction.
J Allergy Clin Immunol
November 2019
KU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium; UZ Leuven, Clinical Division of Paediatrics, Leuven, Belgium. Electronic address:
Innate lymphoid cells in asthma: pathophysiological insights from murine models to human asthma phenotypes.
Curr Opin Allergy Clin Immunol
February 2019
Department of Microbiology and Immunology, Laboratory of Clinical Immunology, KU Leuven, Leuven, Belgium.
Purpose Of Review: The current review describes the role of different types of innate lymphoid cells (ILCs) in the pathogenesis of asthma inflammatory phenotypes by linking findings from murine asthma models with human studies. Novel treatment options are needed for patients with steroid-insensitive asthma. Strategies targeting ILCs, or their upstream or downstream molecules are emerging and discussed in this review.
View Article and Find Full Text PDFAQUA Questionnaire as prediction tool for atopy in young elite athletes.
Pediatr Allergy Immunol
September 2018
Laboratory of Paediatric Immunology, KU Leuven, Leuven, Belgium.