1,482 results match your criteria: "Clinical College of Nanjing Medical University[Affiliation]"
The Efficacy and Safety of Liraglutide in Patients Remaining Obese 6 Months after Metabolic Surgery.
Diabetes Ther
December 2024
Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Zhongshan Road 321, Nanjing, 210008, China.
Introduction: The safety and efficacy of liraglutide as a weight loss intervention in individuals who remain obese within 1 year post-metabolic surgery remain unclear. This study aimed to evaluate the effects and safety of liraglutide (1.8 mg) in patients with persistent obesity at 6 months postoperatively.
View Article and Find Full Text PDFIntravenous versus oral tranexamic acid in elderly transforaminal lumbar interbody fusion patients: A prospective cohort study.
Clin Neurol Neurosurg
November 2024
Department of Orthopedics, Lianyungang Clinical College of Nanjing Medical University, 6 Zhenhua East Rd, Lianyungang 221000, China. Electronic address:
Article Synopsis
- Tranexamic acid (TXA) effectively reduces blood loss and transfusion rates during spinal surgeries, particularly important for elderly patients facing complications due to multiple surgical levels.
- A study involving 958 patients undergoing transforaminal lumbar interbody fusion (TLIF) compared the effects of oral versus intravenous TXA versus a control group to measure outcomes like total blood loss and transfusion rates.
- Results showed that while TXA significantly reduced perioperative bleeding in two-level and three-level surgeries, there was no marked difference in outcomes for one-level surgeries, and intravenous TXA had a lower drainage volume compared to oral TXA in the latter cases.
Gut microbiota alterations in adolescent idiopathic scoliosis: a comparison study with healthy control and congenital scoliosis.
Spine Deform
October 2024
Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing, 210008, China.
Purpose: This study aims to compare the composition of GM isolated from individuals with AIS or congenital scoliosis (CS) and age-matched control (Ctr).
Methods: A total of 48 patients with AIS, 24 patients with CS, and 31 healthy individuals were recruited as the discovery cohort, and 9 pairs of siblings where one was affected by AIS were recruited as the validation cohort. The GM profile was determined with 16S rRNA sequencing, and the alpha-diversity and beta-diversity metrics were performed with Mothur.
Mediation effect analysis of lipoprotein levels on BMI and cardiovascular outcomes in patients with heart failure.
BMC Cardiovasc Disord
October 2024
Department of Cardiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Zhongshan Road, Nanjing, 210008, China.
Article Synopsis
- Heart failure patients with obesity tend to have a better prognosis than those with normal weight, a phenomenon referred to as the "obesity paradox."
- A study involving 1,663 hospitalized heart failure patients analyzed the relationship between Body Mass Index (BMI), lipoprotein levels, and health outcomes using survival analysis and mediation analysis.
- The findings indicated that higher BMI was linked to lower all-cause and cardiovascular mortality, with triglyceride levels serving as the most significant mediator in the relationship between BMI and cardiovascular outcomes.
Identification of oxylipins and lipid mediators in pulmonary embolism.
Lipids Health Dis
October 2024
Department of Clinical Laboratory Medicine, The Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
Article Synopsis
- This study explored the connection between oxylipins, lipid mediators, and Pulmonary Embolism (PE) in a large group of hospitalized patients with thrombosis compared to healthy individuals.
- Among the hospitalized patients, 72.1% had venous thromboembolism, with a 12.1% incidence rate of PE, showing significant changes in coagulation and lipid levels in the PE group compared to controls.
- The analysis revealed a notable upregulation of oxidized lipid metabolites, particularly linked to the arachidonic acid metabolism, suggesting its crucial role in the development of PE.
Protective effect and mechanism of lycium barbarum polysaccharide against UVB-induced skin photoaging.
Photochem Photobiol Sci
October 2024
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Background: Cellular senescence can be categorized into two main types, including exogenous and endogenous aging. Photoaging, which is aging induced by ultraviolet (UV) radiation, significantly contributes to exogenous aging, accounting for approximately 80% of such cases. Superoxide Dismutase (SOD) is a class of antioxidant enzymes, with SOD2 being predominantly localized in the mitochondrial matrix.
View Article and Find Full Text PDFClinical implications of CT-detected ascites in gastric cancer: association with peritoneal metastasis and systemic inflammatory response.
Insights Imaging
October 2024
Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 210008, Nanjing, China.
Article Synopsis
- This study evaluated the relationship between CT-detected ascites and peritoneal metastasis (PM) in gastric cancer patients, finding that many with ascites did not have PM.
- The researchers analyzed various systemic inflammatory indexes, tumor markers, and characteristics of ascites from 111 patients, discovering significant differences between those with and without PM.
- Findings suggest that upper abdominal ascites are clinically important for diagnosing PM, and higher systemic inflammatory indexes are associated with increased ascites volume in patients with PM.
Corrigendum to "Thirdhand smoke exposure promotes gastric tumor development in mouse and human" [Environ. Int. 191 (2024) 108986].
Environ Int
October 2024
Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China; Department of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China. Electronic address:
Establishment and Validation of Prognostic Nomograms for Nonmetastatic Melanoma of the Limbs-A SEER-Based Study.
J Invest Surg
December 2024
Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Article Synopsis
- This study investigates factors that predict the survival of patients with nonmetastatic cutaneous melanoma on their limbs, aiming to create nomograms for overall survival (OS) and cancer-specific survival (CSS).
- The research analyzed a large patient cohort (15,606 individuals) using various statistical methods to identify key prognostic factors, such as age, tumor thickness, and treatment types, and developed predictive nomograms that showed strong accuracy in tests.
- The resulting nomograms serve as valuable tools for doctors to personalize risk management and improve outcomes for patients with this aggressive form of skin cancer.
Postoperative Coronal Imbalance in Lenke 5C Adolescent Idiopathic Scoliosis: Evolution, Risk Factors, and Clinical Implications.
Neurospine
September 2024
Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Objective: To explore the changes in coronal imbalance (CIB) in Lenke 5C adolescent idiopathic scoliosis (AIS) after posterior selective fusion surgery and determine their implications for surgical decision-making.
Methods: One hundred twenty patients were categorized according to the preoperative coronal pattern (type A, coronal balance distance [CBD]<20 mm; type B, CBD≥20 mm and coronal C7 plumbline [C7PL] shifted to the concave side of the curve; type C, CBD≥20 mm and C7PL shifted to the convex side of the curve). CIB group (CIB+) was defined as having a CBD≥20 mm at the 2-year follow-up.
Predicting postoperative mechanical complications with the ethnicity-adjusted global alignment and proportion score in degenerative scoliosis: does paraspinal muscle degeneration matter?
Spine J
February 2025
Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. Electronic address:
Article Synopsis
- - The study focuses on improving the ethnicity-adjusted GAP score (C-GAP score) for predicting mechanical complications after spinal surgery in Chinese degenerative scoliosis patients by factoring in paraspinal muscle degeneration, which is linked to complication severity.
- - Researchers analyzed 107 adult patients who underwent spinal fusion surgery to assess the correlation between their C-GAP scores, muscle degeneration, and clinical outcomes.
- - The findings suggest that incorporating muscle degeneration indices into the C-GAP score may enhance its predictive accuracy for mechanical complications in these patients, potentially leading to better surgical outcomes.
High-throughput and multimodal profiling of antigen-specific T cells with a droplet-based cell-cell interaction screening platform.
Biosens Bioelectron
January 2025
Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen, 518107, China. Electronic address:
Article Synopsis
- Identifying antigen-specific T cells from tumors is crucial for developing effective immunotherapies, but traditional techniques face challenges in efficient and simultaneous screening.
- The new method, DropCCI, uses droplets to link antigen information to T cells while preventing contamination, enabling high-throughput and precise multimodal profiling.
- DropCCI utilizes click chemistry for rapid single-cell sequencing, avoiding complex equipment and allowing for a clearer understanding of T cell responses, with potential applications beyond immunotherapy.
Association of gastrointestinal symptoms with mortality in patients with severe fever with thrombocytopenia syndrome.
Heliyon
September 2024
Department of Respiratory Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Article Synopsis
- * A study of 304 hospitalized SFTS patients from 2010 to 2022 found that those with GI symptoms had different demographic and lab results, such as a lower percentage of males and higher enzyme levels, compared to those without GI symptoms.
- * Despite the prevalence of GI symptoms, the study concluded that they did not significantly impact mortality rates or the likelihood of ICU admission, indicating they are not an independent risk factor for worse outcomes in SFTS patients.
Non-Coding RNA Networks in Pulmonary Arterial Hypertension.
Pharmacology
September 2024
Department of Pharmacy, The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People's Hospital of Lianyungang, Lianyungang, China.
Article Synopsis
- - Pulmonary artery hypertension (PAH) is a serious cardiovascular condition that results in high pressure in the pulmonary arteries, leading to heart strain and potential heart failure, with current treatments not fully addressing the problem.
- - Recent studies have identified non-coding RNAs (ncRNAs), such as lncRNAs, circRNAs, miRNAs, and piRNAs, as key players in the development of PAH, affecting disease progression without coding for proteins.
- - The research highlights the need for more understanding of ncRNAs in PAH and suggests that they could be useful as biomarkers for diagnosis and as therapeutic targets to improve treatment options for the disease.
Effects of tenofovir alafenamide fumarate on serum lipid profiles in patients with chronic hepatitis B.
Virol J
September 2024
Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, No. 321 Zhongshan Road, Nanjing, Jiangsu, 210008, China.
Background: Concerns have been raised regarding changes in lipid profiles among patients with chronic hepatitis B (CHB) during tenofovir alafenamide fumarate (TAF) treatment. We aimed to evaluate the effect of TAF treatment on the lipid profiles of patients with CHB.
Methods: A total of 430 patients with CHB from three hospitals were retrospectively included, including 158 patients treated with TAF and 272 patients treated with tenofovir disoproxil fumarate (TDF).
Detection of the Fatty Acid Metabolism-Linked Genes in Lung Adenocarcinoma as Biomarkers for Clinical Prognosis and Immunotherapeutic Targets.
Clin Respir J
October 2024
Department of Thoracic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province, China.
Background: Lung cancer, on a global scale, leads to the most common cases of cancer mortalities. Novel therapeutic approaches are urgently needed to disrupt this lethal disease. The rapid development of tumor immunology combining breakthroughs involving fatty acid metabolism brings possibilities.
View Article and Find Full Text PDFMulti-step gene set analysis identified HTR3 family genes involving childhood acute lymphoblastic leukemia susceptibility.
Arch Toxicol
January 2025
Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Article Synopsis
- A previous study identified the WWOX gene as a risk factor for developing acute lymphoblastic leukemia (ALL), leading to deeper genetic analysis of the disease using a sample of 269 cases and 1039 controls from Chinese descent.
- The analysis revealed that the serotonin-activated cation-selective channel complex gene-set plays a significant role in ALL, with the T allele of rs33940208 linked to a lower risk of developing the disease, and the A allele of rs6779545 associated with a higher risk.
- Combining these genetic variants showed that having multiple risk alleles significantly increases the likelihood of developing childhood ALL, highlighting the need for further research to understand the molecular mechanisms involved and improve prevention strategies.
GFPT2: A novel biomarker in mesothelioma for diagnosis and prognosis and its molecular mechanism in malignant progression.
Br J Cancer
November 2024
Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Article Synopsis
- Mesothelioma (MESO) is a challenging cancer with poor outcomes, and the study identifies GFPT2 as a key biomarker for diagnosing and predicting its progression.
- Using various methods, including tissue samples and advanced lab techniques, the research highlights GFPT2's significant role in enhancing MESO's malignancy and its potential in driving aggressive cancer behavior.
- The findings position GFPT2 as not only a vital diagnostic tool for MESO but also a promising target for new treatment approaches, potentially improving management strategies for this disease.
Association of hepatitis B core antibody level and hepatitis B surface antigen clearance in HBeAg-negative patients with chronic hepatitis B.
Virulence
December 2024
Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Predicting hepatitis B surface antigen (HBsAg) clearance is important for chronic hepatitis B (CHB) patients receiving pegylated interferon-alfa (Peg-IFN) therapy. We aimed to determine the predictive value of serum hepatitis B core antibody (anti-HBc) for HBsAg clearance. A total of 189 HBeAg-negative CHB patients who received Peg-IFN based therapy were retrospectively included and classified into two groups: nucleos(t)ide analogues (NAs) add-on Peg-IFN group (add-on group, = 94) and Peg-IFN combined with NAs or Peg-IFN monotherapy group (combination or monotherapy group, = 95).
View Article and Find Full Text PDFCorrelation of lower limb alignment with medial mensical extrusion in knee osteoarthritis.
Arch Orthop Trauma Surg
November 2024
Lianyungang Clinical College of Nanjing Medical University, No. 6 Zhenhua East Road, Haizhou District, Lianyungang City, Jiangsu Province, China.
Background: This study aims to explore the relationship between Lower limb alignment parameters and the degree of Medial Meniscal Extrusion (MME) in patients with Knee Osteoarthritis (KOA), in hopes of providing new reference data for the prevention and treatment of KOA.
Methods: A retrospective study design was employed, analyzing 623 KOA patients treated at our hospital from 2022 to 2023, with 307 patients' information collected according to inclusion and exclusion criteria. Patients were divided into mild and severe groups based on the degree of MME, and differences in Lower limb alignment parameters between the two groups were compared.
NIR-II Orthogonal Fluorescent Ratiometric Nanoprobe for In Situ Bioimaging of Carbon Monoxide.
Small
December 2024
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Carbon monoxide (CO) functions as a significant endogenous cell signaling molecule and is strongly associated with many physiological and pathological processes. However, conventional fluorescence imaging in the visible and near-infrared (NIR) I regions suffers autofluorescence background and photon scattering, hindering the accurate detection of CO in vivo. In addition, the complexity of physiological environments leads to fluctuating fluorescence emission.
View Article and Find Full Text PDFIron metabolism indexes as predictors of the incidence of cardiac surgery-associated acute kidney surgery.
J Cardiothorac Surg
September 2024
Department of Intensive Care Unit, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, Jiangsu, China.
Background: Acute kidney injury (AKI) is a major complication following cardiac surgery. We explored the clinical utility of iron metabolism indexes for identification of patients at risk for AKI after cardiac surgery.
Methods: This prospective observational study included patients who underwent cardiac surgery between March 2023 and June 2023.
The presence of genes encoding carbapenem-hydrolyzing oxacillinase and lack of carbapenem resistance in non-baumannii Acinetobacter misidentified as Acinetobacter baumannii causing bloodstream infections in a tertiary hospital over a 3-year period.
Infect Genet Evol
November 2024
Department of Infectious Disease, Nanjing Drum Tower Hospital, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. Electronic address:
Objective: This study aims to analyze the genomic and clinical characteristics of Non-baumannii Acinetobacter strains misidentified as A. baumannii, causing bloodstream infections (BSIs) in our hospital.
Materials And Methods: Whole genome sequencing was performed and average nucleotide identity (ANI) was analyzed.
Severe stress cardiomyopathy following spinal corrective surgery for scoliosis complicated with pectus excavatum: a case report.
BMC Anesthesiol
September 2024
Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Article Synopsis
- Stress cardiomyopathy (SCM) is a temporary heart condition that can cause severe issues like heart failure, and it has been rarely seen in patients undergoing spinal surgery.
- A case report details a scoliosis patient who developed severe SCM during her surgery wake-up period, resulting in circulatory collapse but ultimately leading to a good recovery after treatment.
- The study emphasizes the importance of early diagnosis and management of SCM, especially for patients with risk factors, to prevent severe complications and improve outcomes.
Dynamic change of lymphocytes associated with short-term prognosis in anti-MDA5-positive dermatomyositis with interstitial lung disease: a multicenter retrospective study.
Clin Rheumatol
November 2024
Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.
Article Synopsis
- Lymphopenia, or low lymphocyte count, is linked to poor short-term outcomes in patients with anti-MDA5 positive dermatomyositis and interstitial lung disease (MDA5 + DM-ILD).
- A study analyzing 263 patients found that lower lymphocyte counts were associated with higher risk of death within one month, particularly when lymphocyte levels declined over time.
- Dynamic changes in lymphocyte levels provide a better indication of disease progression and prognosis than just looking at initial lymphocyte counts at baseline.