1 results match your criteria: "Clinical Colledge of Nanjing Medicial University[Affiliation]"
Biomarkers.
Alzheimers Dement
December 2024
Department of Radiology, Drum Tower Hospital, Clinical Colledge of Nanjing Medicial University, Nanjing 210008, china, Nanjing, China.
Background: It remains unclear to what extent APOEε4 relates to amyloid beta (Aβ) and tau deposition, functional connectivity and neurodegeneration in Alzheimer's disease spectrum.
Method: In 345 participants including subjective cognitive impairment and mild cognitive impairment and Alzheimer disease, We investigate the association of APOEε 4 with Aβ and Tau, functional connectivity and neurodegeneration (cortical thickness and gray matter volume). Using mediation analyses, we tested the indirect effects of APOEε4 on neurodegeneration via Tau deposition (F-AV451 positron emission tomography) and interregional functional connectivity (functional MRI) in Braak I-II and Braak III-VI.