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508 results match your criteria: "Clinical Center Nis[Affiliation]"
Radiol Med
December 2024
Department of Radiology, ASST Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127, Bergamo, Italy.
Coronary computed tomography angiography (CCTA) is a powerful tool to rule out coronary artery disease (CAD). In the last decade, myocardial perfusion CT (CTP) technique has been developed for the evaluation of myocardial ischemia, thereby increasing positive predictive value for diagnosis of obstructive CAD. A diagnostic strategy combining CCTA and perfusion acquisitions provides both anatomical coronary evaluation and functional evaluation of the stenosis, increasing the specificity and the positive predictive value of cardiac CT.
View Article and Find Full Text PDFFront Med (Lausanne)
December 2024
Department of Infectious Diseases and Epidemiology, Faculty of Medicine, University of Niš, Niš, Serbia.
Acute hepatitis E virus (HEV) and malaria are not rare infections in tropical countries; however, in the European continent, such imported entity has not been reported up to now. Herein, we report a 24-year-old male suffering from malaria and hepatitis E, who was admitted with acute hepatic failure dark colored urine, followed by coagulation and inflammation parameters increase. Blood smear analysis revealed the presence of , while serological tests revealed anti-HEV IgM antibodies.
View Article and Find Full Text PDFJ Clin Med
December 2024
Faculty of Medicine, University of Niš, Blvd. Dr Zorana Đinđića 81, 18000 Niš, Serbia.
Uterine torsion represents a rare condition that may occur during pregnancy or in non-gravid women. This condition is difficult to diagnose, since there are no specific signs besides abdominal pain. Thus, most of the cases are not diagnosed correctly before a surgical procedure and may result in complications and poor outcomes.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
December 2024
Department of Cardiology, University Hospital Basel, Basel, Switzerland.
Background: Advancing the retrograde microcatheter (MC) into the antegrade guide catheter during retrograde chronic total occlusion (CTO) percutaneous coronary intervention (PCI) can be challenging or impossible, preventing guidewire externalization.
Objectives: To detail and evaluate all the techniques focused on wiring to achieve intubation of the distal tip of a microcatheter, balloon, or stent with an antegrade or retrograde guidewire, aiming to reduce complications by minimizing tension on fragile collaterals during externalization and enabling rapid antegrade conversion in various clinical scenarios.
Methods: We describe the two main techniques, tip-in and rendezvous, and their derivatives such a facilitated tip-in, manual MC-tip modification, tip-in the balloon, tip-in the stent, deep dive rendezvous, catch-it and antegrade microcatheter probing.
Viruses
October 2024
Radiology Center, Medical Faculty, University Clinical Center Nis and University of Nis, 18000 Niš, Serbia.
The aim of this study is to examine the prognostic role of initial chest computed tomography severity score index (CTSS) and its association with demographic, socio-epidemiological, and clinical parameters in COVID-19 hospitalized patients. A retrospective study included patients who were hospitalized in the COVID Hospital of the Clinical Hospital Center Kosovska Mitrovica from July 2020 to March 2022. We compared patient characteristics and outcome of their hospital stay with values of CT severity score (mild, moderate, and severe form of the disease).
View Article and Find Full Text PDFPathogens
November 2024
Diagnostics and Laboratory Research Task Force, Balkan Association for Vector-Borne Diseases, 21000 Novi Sad, Serbia.
Tick-borne encephalitis (TBE) is a vaccine-preventable viral infection that poses significant public health challenges, particularly in regions where tick-borne diseases are endemic. This case report describes a 2-year-old boy with confirmed abortive TBEV infection following a tick bite during travel to Switzerland. The patient developed fever and mild symptoms but did not exhibit central nervous system involvement.
View Article and Find Full Text PDFMedicina (Kaunas)
October 2024
Medical Faculty, University of Nis, 18000 Nis, Serbia.
: Patients undergoing chronic hemodialysis (HD) are predisposed to both thrombotic and bleeding complications due to the complex interplay of end-stage renal disease (ESRD), cardiovascular comorbidities, and the routine use of anticoagulant and antiplatelet therapies. This study aimed to investigate the incidence of bleeding and thrombotic events in chronic HD patients receiving anticoagulant and antiplatelet therapy, with a specific focus on those with atrial fibrillation (AF). : A total of 224 patients, with 43 (19%) of them diagnosed with AF, were included in this single-center, observational cohort study conducted over 24 months.
View Article and Find Full Text PDFWorld J Clin Oncol
November 2024
Clinic for Digestive Surgery, University Clinical Center, Medical Faculty University of Nis, Nis 18000, Serbia.
Background: Primary pancreatic lymphoma (PPL) is a rare tumor that mimics pancreatic adenocarcinoma, leading to diagnostic and therapeutic challenges. PPL accounts for 0.2% of all pancreatic tumors and is typically treated with chemotherapy.
View Article and Find Full Text PDFJCO Oncol Pract
November 2024
Luca Arecco, MD, Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genova, Genova, Italy, Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Academic Trials Promoting Team, Brussels, Belgium; Abeid Omar, MD, Department of Clinical Oncology, Kenyatta University Teaching, Referral and Research Hospital (KUTRRH), Nairobi, Kenya; Luciana de Moura Leite, MD, Department of Medical Oncology, A.C. Camargo Cancer Center, São Paulo, Brazil; Kristina Janković, MD, Clinic of Oncology, University Clinical Center Nis, Nis, Serbia; Gabriella Gentile, MD, Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, Rome, Italy; Mihaela Stana, MD, Department of Medical Oncology, Elysée Hospital, Alba Iulia, Romania; Hatem A. Azim Jr, MD, PhD, Cairo Cure Oncology Center, Cairo, Egypt; and Matteo Lambertini, MD, PhD, Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genova, Genova, Italy, Department of Medical Oncology, U.O.C. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Foodborne Pathog Dis
November 2024
Public Health Institute Niš, Niš, Serbia.
We performed a literature review focusing on case reports and case series studies, aiming to better define the clinical presentation of isolated lateral intraventricular neurocysticercosis (LVNCC) and to discuss the current knowledge of its characteristics, patient demographics, clinical manifestations, treatment, and prognosis, based on the collected data. Data for this study were gathered by conducting searches on the Medline database and Google Scholar using various combinations of the following terms "intraventricular neurocysticercosis (IVNCC)," "brain ventricle cyst," "cysticercosis of lateral brain ventricles," "cysticercus cyst in brain ventricles," and "intraventricular cystic brain lesion." Articles published in English between January 1980 and March 2023 that reported cases of LVNCC were selected for analysis.
View Article and Find Full Text PDFXenobiotica
October 2024
Clinic of Nephrology, University Clinical Center Nis, Nis, Serbia.
1. Introduction: The study aimed to investigate the influence of interleukin (IL)-6 -174 G/C gene polymorphism on graft function (defined as estimated glomerular filtration rate, eGFR), as well as on the tacrolimus (Tac) pharmacokinetics during the five years after kidney transplantation.
2.
Pharmaceuticals (Basel)
October 2024
Lee Health Heart Institute, Fort Myers, FL 33908, USA.
Background: Immune checkpoint inhibitors (ICIs) have been successfully used in the previous decade for the treatment of a variety of malignancies. Adverse events (AEs) can cause many symptoms, most notably cardiac. We analyzed the frequency of these adverse events, comparing pembrolizumab and other ICIs.
View Article and Find Full Text PDFPharmazie
October 2024
Clinic for Oncology, University Clinical Center Nis, Serbia.
Tapentadol is a unique opioid analgesic due to its dual mechanism of action. Compared to other opioids with a classical mechanism of action, its analgesic potential is not far behind them, and its advantages are: a better safety profile in terms of a lower potential for drug-drug interactions and a lower potential for causing adverse events, and it is safe to use in sensitive populations. Tapentadol in the form of a immediate release formulation is an adequate drug of choice for achieving a pharmacotherapeutic analgesic response in acute pain conditions, while in the form of a extended release formulation it is an adequate pharmacotherapeutic analgesic solution for chronic pain syndromes of various etiology.
View Article and Find Full Text PDFPharmazie
October 2024
Department for Oncology, Faculty of Medicine, University of Nis; Clinic for Oncology, University Clinical Center Nis, Serbia.
The incorporation of bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF), has redefined therapeutic strategies for advanced ovarian cancer. This study evaluates the efficacy of bevacizumab combined with standard chemotherapy by comparing progression-free survival (PFS) and overall survival (OS) outcomes with a historical cohort of patients treated with standard chemotherapy alone. We conducted an analysis of 71 patients with advanced epithelial ovarian cancer treated at the University Clinical Center in Niš, Serbia, from April 2017 to March 2023.
View Article and Find Full Text PDFDiagnostics (Basel)
September 2024
Clinic of Nephrology Prof Dr Spira Strahinjić, University Clinical Center Niš, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.
Pathophysiology
September 2024
N.A. Semashko Public Health and Healthcare Department, F.F. Erismann Institute of Public Health, I.M. Sechenov First Moscow State, 119435 Moscow, Russia.
: The pathophysiological mechanism underlying pregnancy complications is not entirely known. Although it is currently impossible to predict the occurrence of redox imbalance, it is possible to identify women with a high or medium risk of developing this disease prior to a negative outcome by non-invasive diagnostic methods. : This study aimed to examine the possible role of the parameter of oxidative stress (OS) measured in early pregnancy in the screening/treatment of obesity and its complications during pregnancy.
View Article and Find Full Text PDFJ Neurol
December 2024
Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia.
Background: The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry.
Methods: Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies.
Curr Vasc Pharmacol
August 2024
Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Serbia.
Systemic arterial hypertension (HTN) is the main cause of morbidity and mortality, and HTN crises contribute significantly to an unfavourable clinical course. For decades, HTN crises have been dichotomized into hypertensive emergency (HTN-E) and hypertensive urgency (HTN-U). The main difference between the two is the presence of acute hypertension-mediated organ damage (HMOD) - if HMOD is present, HTN crisis is HTN-E; if not, it is HTN-U.
View Article and Find Full Text PDFCureus
July 2024
Department for Cardiovascular Diseases, Institute for Treatment and Rehabilitation Niska Banja, Nis, SRB.
Atrial fibrillation (AF) is the most common long-term arrhythmia in adults. Rhythm control in patients with AF involves efforts to restore and maintain sinus rhythm and is accomplished by medication, catheter ablation, or electrical cardioversion. Amiodarone represents one of the most commonly used antiarrhythmic medications.
View Article and Find Full Text PDFESMO Open
August 2024
Center for Dermato-oncology, Department of Dermatology, Eberhard Karls University of Tübingen, Tübingen; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Tübingen. Electronic address:
Background: The introduction of anti-programmed cell death protein 1 (PD-1) immunotherapy has revolutionized the treatment landscape for melanoma, enhancing both response rates and survival outcomes in patients with advanced stages of the disease. Despite these remarkable advances, a noteworthy subset of patients (40%-60%) does not derive advantage from this therapeutic approach. This study aims to identify key predictive factors and create a user-friendly predictive nomogram for stage IV melanoma patients receiving first-line anti-PD-1-based immunotherapy, improving treatment decisions.
View Article and Find Full Text PDFIran J Public Health
July 2024
Department of Medical Statistics and Informatics, Medical Faculty University of Niš, Niš, Serbia.
Background: We aimed to evaluate the quality of the cause of death (COD) concerning mortality patterns and completeness of death registration to identify areas for improvement in Serbia.
Methods: COD data collected from the mortality register in Serbia from 2005 to 2019 (1540615 deaths) were analyzed with the software Analysis of National Causes of Death for Action. The Vital Statistics Performance Index for Quality (VSPI(Q)) is estimated for the overall COD data quality.
Rev Cardiovasc Med
August 2023
Faculty of Medicine, Department of Internal Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Spontaneous coronary artery dissection (SCAD) is a non-traumatic, non-atherosclerotic layering of the coronary artery wall due to the presence of a subintimal hematoma or an intimal tear with the creation of a false lumen that compresses the true lumen and restricts or obstructs the flow. Patients with SCAD and preserved coronary flow are treated conservatively according to the general recommendations. However, percutaneous coronary intervention should be considered in patients with artery occlusion and/or refractory ischemia.
View Article and Find Full Text PDFPharmacogenomics
September 2024
University Clinical Center Nis, Clinic of Nephrology, Nis, Serbia.
IL-6 and IL-10 may affect the activity of cytochrome P450 (CYP) 3A enzymes involved in tacrolimus (Tac) metabolism. Moreover, the effect of IL-6 and IL-10 on Tac pharmacokinetics may differ with respect to the genetic variations in their genes. To examine the influence of IL-6 and IL-10 gene polymorphisms on Tac dose requirements and exposure over a 5-year period following kidney transplantation.
View Article and Find Full Text PDFMedicina (Kaunas)
June 2024
Department of Physiology, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.
: Even though measles is easily prevented by vaccination, infection outbreaks are not rare. Infection carries a great risk for pulmonary complications, which are sometimes hard to predict, especially in a group of outpatients. This study aims to evaluate the association between serum CRP changes and the severity of respiratory complications in the group of inpatients treated for measles.
View Article and Find Full Text PDFJ Pers Med
June 2024
Lee Health Heart Institute, Fort Myers, FL 33908, USA.
Spontaneous coronary artery dissection (SCAD) is a spontaneous intimal tear of the coronary artery wall. A factor rarely associated with SCAD is autosomal dominant polycystic kidney disease (ADPKD). Using the PRISMA guidelines, we identified 10 unique cases of SCAD in ADPKD patients reported between 1998 and 2021.
View Article and Find Full Text PDF