1,419 results match your criteria: "Clinical Affairs[Affiliation]"

Article Synopsis
  • This study explored the link between fetal fraction (amount of fetal DNA in the mother's blood) and low birth weight in twin pregnancies, aiming to understand how these factors relate, especially in the first trimester.
  • The analysis included 1,041 twin pregnancies and found that no significant differences in fetal fraction existed between twins with low birth weight (<10th percentile) and those with normal birth weight (≥10th percentile).
  • Ultimately, the results indicated no correlation between high or low fetal fractions and low birth weight, suggesting that fetal fraction is not a reliable predictor of adverse birth weight outcomes in twin pregnancies.
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Introduction: The advent of digital and mobile health innovations, especially use of wearables for passive data collection, allows remote monitoring and creates an abundance of data. For this information to be interpretable, machine learning (ML) processes are necessary.

Research Question: Can a machine learning model successfully identify patients expected to have low gait speed in the early recovery period following joint replacement surgery?

Methods: A commercial database from a smartphone-based care management platform passively collecting mobility data pre- and post-lower limb arthroplasty was used.

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  • The study looks at how many days patients with hard-to-treat epilepsy can go without seizures after getting a treatment called vagus nerve stimulation (VNS).
  • They looked at 362 patients over three years and found that only about 11% had complete freedom from all types of seizures for at least a year, but 55% of those with a specific kind of seizure (TCS) did experience this.
  • Patients who went a year without any seizures reported that their quality of life got much better compared to those who still had seizures.
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Deep Learning-Based ASPECTS Algorithm Enhances Reader Performance and Reduces Interpretation Time.

AJNR Am J Neuroradiol

September 2024

From the Departments of Clinical Affairs and Research & Development (A.A., M.T., S.Q., S.F., C.A., Y.C.), Avicenna.AI, La Ciotat, France. From the Department of Engineering (A.D.), Amalgamated Vision, LLC, Brentwood, TN, USA. From the Department of Radiological Sciences (P.D.C., D.S.C., D.F.), University of California Irvine, Orange, CA, USA. From the Center for Artificial Intelligence in Diagnostic Medicine (P.D.C., D.S.C.), University of California Irvine, Orange, CA, USA. From the David Geffen School of Medicine (K.N.), UCLA, Los Angeles, CA, USA. From Advance Research Associates (P.S.) Santa Clara, CA, USA.

Article Synopsis
  • The ASPECTS criteria for assessing acute ischemic stroke is complex, leading to variability in interpretations among physicians, prompting a study to evaluate the impact of a deep learning (DL) algorithm on clinicians' performance.
  • A total of 200 non-contrast CT scans were reviewed by various clinicians with and without the support of the CINA-ASPECTS algorithm, which automates the ASPECTS assessment.
  • Results showed that the software improved accuracy and consistency in evaluations while also reducing the time needed for assessment, indicating its potential to enhance clinical decision-making in stroke treatment.
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Article Synopsis
  • The CALCIPHYX trial tested hexasodium fytate, a potential treatment for calciphylaxis, a rare condition causing painful skin lesions, in a double-blind, placebo-controlled setting.
  • Out of the randomised patients, both those receiving hexasodium fytate and the placebo group showed similar improvements in wound assessment and pain scores after 12 weeks, indicating no significant benefit from the treatment over placebo.
  • Serious adverse events were lower in the fytate group compared to the placebo group, suggesting that hexasodium fytate may be safer, but there was no substantial difference in healing or pain reduction between the two groups.
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Article Synopsis
  • The COMFORT Study aims to assess the safety and effectiveness of Nalu Neurostimulation for treating chronic neuropathic pain compared to standard medical treatment.
  • This randomized controlled trial (RCT) will involve multiple centers, focusing on pain in specific areas like the low back, shoulder, knee, or foot/ankle and following participants for 36 months.
  • The findings could provide crucial evidence supporting the use of Peripheral Nerve Stimulation (PNS) for chronic pain, as it would be the largest and first Level-I evidence study on this therapy.
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Article Synopsis
  • In 2005, routine vaccination against invasive meningococcal disease (IMD) was recommended for 11-12-year-olds and high-risk children aged 2-10, followed by a 2010 booster for 16-year-olds.
  • Optional vaccination against serogroup B was introduced in 2015, with a new combined vaccine (MenABCWY) for five serogroups available in 2023.
  • The review discusses how these policy changes aim to improve vaccination coverage and efficiency while addressing disparities in immunization.
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Robotics and artificial intelligence have marked the beginning of a new era in the care and integration of people with disabilities, helping to promote their independence, autonomy and social participation. In this area, bioethical reflection assumes a key role at anthropological, ethical, legal and socio-political levels. However, there is currently a substantial diversity of opinions and ethical arguments, as well as a lack of consensus on the use of assistive robots, while the focus remains predominantly on the usability of products.

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Article Synopsis
  • - Acute transverse myelitis (TM) is a rare spinal cord disorder characterized by symptoms like motor weakness, sensory changes, and bowel or bladder dysfunction, affecting mostly younger and middle-aged adults, although this case involves a 72-year-old male.
  • - The patient, with a history of hypertension and type 2 diabetes, presented with upper extremity weakness and new abdominal numbness after a trip to a theme park, leading to a diagnosis of TM confirmed by MRI and lumbar puncture.
  • - The patient's TM was linked to newly diagnosed Sjögren's autoimmune disease, and although he was treated with intravenous steroids, he was readmitted due to poor adherence to discharge instructions, highlighting the need for quick recognition and treatment to prevent further
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The performance of a novel selective agar was evaluated against the performance of conventional mycobacterial cultures, i.e., a combination of the mycobacterial growth indicator tube (MGIT) with Löwenstein-Jensen (LJ), for the detection of nontuberculous mycobacteria (NTM) in sputum samples from people with cystic fibrosis (pwCF).

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Customizing implant emergence profile and provisional prostheses. Combination of the digital and the analog protocol. A Case Report.

J Clin Exp Dent

June 2024

DDS, MS, PhD. Clinical Professor and Associate Dean for Clinical Affairs and Quality Assurance, Department of Restorative Dental Sciences, College of Dentistry, University of Florida, Gainesville, FL, USA.

The emergence profile in implant restoration has an important contribution to the final esthetic result. Moreover, a properly shaped emergence profile enables well-performed dental hygiene and protects the implant-restoration complex from peri-implant infections. This report describes a clinical case that combines digital workflow and designing with a custom implant healing abutment system (Cervico).

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Clinical trials often demonstrate treatment efficacy through change in forced expiratory volume in one second (FEV), comparing single FEV measurements from post- versus pre-treatment timepoints. Day-to-day variation in measured FEV is common for reasons such as diurnal variation and intermittent health changes, relative to a stable, monthly average. This variation can alter estimation of associations between change in FEV and baseline in predictable ways, through a phenomenon called regression to the mean.

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Unlabelled: Serogroup B (MenB) is the leading cause of invasive meningococcal disease among adolescents and young adults in the United States. The US Advisory Committee on Immunization Practices (ACIP) recommends MenB vaccination based on shared clinical decision making between patients and providers. However, suboptimal understanding of these recommendations could contribute to low vaccination awareness and coverage.

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Are physical and mechanical properties of 3D resins dependent on the manufacturing method?

Odontology

August 2024

Associate Professor, Department of Advanced Specialty Sciences, James B. Edwards College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA.

This research analyzed the effect of the manufacturing method on the flexural strength and color stability of 3D-printed resins used for producing indirect restorations. For this, two dental restorative biocompatible resin materials, OnX (OnX, SprintRay) and CB (Crown and Bridge, Dentca), were divided into 2 groups according with manufacturing method (printed with a Pro95 3D printer - SprintRay; and not printed, with samples obtained with the fluid resin being poured on PVS molds for further light activation in the post-curing process), and subdivided into 2 groups according to the post-curing method: VG (Valo Grand, Ultradent Products) for 120 s and PC (Procure 2, SprintRay). Bar-shaped samples were used to evaluate the flexural strength 24 h after storage in distilled water at 37 °C using a universal testing machine.

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Article Synopsis
  • - The Navitor IDE study examines the safety and effectiveness of the Navitor valve for patients with severe aortic stenosis who are at high surgical risk, focusing on the connection between patient factors and the rate of new permanent pacemaker implantation (PPI) within 30 days post-surgery.
  • - Researchers analyzed data from 260 patients, excluding those with prior pacemakers, and found that specific conduction abnormalities, like first-degree atrioventricular block and right bundle branch block, increased the likelihood of new PPI, while the depth of the valve implantation also played a significant role.
  • - The study concludes that both existing conduction issues and the surgical technique (implant depth) are critical predictors of whether patients will need a new pacemaker
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Bone marrow lesions (BMLs) are MRI-visible subchondral bone alterations, highly correlated with symptoms in the knee. Subchondroplasty (SCP) is able to fill the subchondral defects associated with BMLs using an injectable bone substitute material. The aim of the present study is to evaluate the 12-month outcomes of the SCP in the treatment of symptoms of mild-to-moderate knee osteoarthritis (OA) patients with persistent BMLs of the knee.

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Functional priorities of individuals with spinal cord injury: a Saudi Arabian perspective.

Spinal Cord

September 2024

Department of Biostatistics, Research Services Administration, Research Center, King Fahad Medical City, Riyadh, Saudi Arabia.

Context/objective: People with spinal cord injury (SCI) are the deciding force behind the rehabilitation program to improve their quality of life (QoL) based on their personal preferences. Here we aimed to determine the preferences perceived most vital by Saudi SCI population to improve their QoL, and explore if these preferences are affected by gender, education, and duration, level, or extent of injury.

Design: Participants ranked seven priorities of bodily functions as Rank I-VII with "I" being "Most important," and "VII" being "Least important.

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Objective: The objective of this work was to establish sustainable systems for quality improvement in an Academic Medical Center and Safety Net Hospital.

Method: High reliability principles of leadership engagement, a culture of safety, and sustainable performance improvement were used. Target areas for improvement were clinical outcomes for patients, public reputation scores, and lower cost of care.

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Objective: The purpose of this study was to examine the association between lifestyle factors and body weight in a nationally representative sample of US adults and to evaluate the association between a novel "Healthy Habits Composite Score (HHCS)" and risk of obesity.

Methods: This cross-sectional study included data from 4870 adults who participated in the 2017-2018 National Health and Nutrition Examination Survey (NHANES). The HHCS was developed based on 4 factors: diet, physical activity, sedentary time, and sleep, all of which were measured during the NHANES.

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