Lactoferrin-modified nanoemulsions enhance brain-targeting and therapeutic efficacy of arctigenin against Toxoplasma gondii-induced neuronal injury.

Toxoplasma gondii, a neurotropic protozoan parasite, affects the central nervous system and causes various neurological disorders. Previous studies have demonstrated that Arctigenin (AG) exhibits anti-T. gondii activity and reduces depression-like behaviors induced by T.

2021 JAPAN Chronic Limb Threatening Ischemia Database (JCLIMB) Annual Report.

Since 2013, the Japanese Society for Vascular Surgery has started the project of nationwide registration and tracking database for patients with critical limb ischemia (CLI) who are treated by vascular surgeons. The purpose of this project is to clarify the current status of the medical practice for patients with CLI to contribute to the improvement of the quality of medical care. This database is created on the National Clinical Database (NCD) and collects data on patients' backgrounds, therapeutic measures, early results, and long-term prognoses as long as 5 years after the initial treatment.

Technical Pitfalls and Tips of Management for Critical Limb Ischemia by Distal Bypass Using the Autogenous Veins.

It is a clear fact that many complications in surgical treatment, not just in cardiovascular surgery, are caused by things related to surgical techniques. In other words, postoperative problems are already determined by preoperative surgical management and intraoperative surgical operations. This describes strategies to avoid the surgical complications of distal bypass using the autogenous veins for each item.

Internet as a Source of Public Health Information on Acupuncture for Pain Relief: Credibility Assessment and Readability Analysis.

Background: In recent years, there has been a notable increase in the number of patients seeking information from online health websites. As the information available on these websites can significantly impact the overall health of individuals in a society, it is vital for online health information to be presented in a manner that is readable and credible to the general public. To address this concern, the objective of the study was to examine and assess the credibility and readability of websites about acupuncture as a pain management approach.

Impact of Timing of Minor Amputations After Revascularization on Patient Outcomes.

Background: Vascular complications from diabetes contribute significantly to major and minor limb amputations. Diabetes is a major health burden in Saudi Arabia, with increased incidence in rural areas. The purpose of this study was to evaluate the timing of minor lower limb amputations after revascularization and their relative outcomes.

ChatGPT-4o's performance on pediatric Vesicoureteral reflux.

Introduction: Vesicoureteral reflux (VUR) is a common congenital or acquired urinary disorder in children. Chat Generative Pre-trained Transformer (ChatGPT) is an artificial intelligence-driven platform offering medical information. This research aims to assess the reliability and readability of ChatGPT-4o's answers regarding pediatric VUR for general, non-medical audience.

Long-term Outcomes of the AcoArt II-BTK Trial: Drug-Coated Balloon Angioplasty Compared With Uncoated Balloons for the Treatment of Infrapopliteal Artery Lesions.

Purpose: Previous studies have indicated mixed short-term outcomes between drug-coated balloon (DCB) angioplasty and percutaneous transluminal angioplasty (PTA) in the treatment of infrapopliteal lesions. However, the long-term durability of DCB angioplasty remains uncertain. The objective of this study is to present the long-term outcomes of DCB angioplasty for infrapopliteal lesions in patients with critical limb ischemia (CLI).

[Successful treatment of rheumatoid arthritis complicated with myasthenia gravis with low-dose rituximab: A case report].

Rheumatoid arthritis (RA) and myasthenia gravis (MG) are two distinct autoimmune diseases. Compared with the general population, the incidence of RA is notably higher among patients with MG. Similarly, the rate of MG in patients diagnosed with RA is also significantly increased.

The promising role of chatbots in keratorefractive surgery patient education.

Purpose: To evaluate the appropriateness, understandability, actionability, and readability of responses provided by ChatGPT-3.5, Bard, and Bing Chat to frequently asked questions about keratorefractive surgery (KRS).

Method: Thirty-eight frequently asked questions about KRS were directed three times to a fresh ChatGPT-3.

blast2galaxy: a CLI and Python API for BLAST+ and DIAMOND searches on Galaxy servers.

Motivation: The Galaxy workflow system is an open-source platform supporting data-intensive research in life sciences, featuring a user-friendly web interface for complex analyses without extensive programming. It also offers a representational state transfer based API, enabling remote execution of specific tools. Galaxy supports similarity searches for nucleotide and amino acid sequences, with integrated tools like NCBI BLAST+ and DIAMOND.

Effect of evolocumab in patients with chronic limb threatening ischemia (Evol-CLI study).

Background: Chronic limb-threatening ischemia (CLTI) is associated with increased risk of major adverse cardiac and limb events (MACLE). In patients with peripheral arterial disease (PAD), evolocumab is associated with decreased MACLE, improved maximal walking time, increased vascular flow-mediated dilation (FMD), and decreased carotid intima-media thickness (IMT). We investigated the additive effect of evolocumab in patients with CLTI on maximally tolerated lipid lowering therapy after an index revascularization for non-healing wounds.

Advanced Wound, Ischemia, and foot Infection stage is associated with poor outcomes in the BEST-CLI trial.

Objective: Wound, Ischemia, and foot Infection (WIfI) staging was established to provide objective classification in patients with chronic limb-threatening ischemia (CLTI) and to predict 1-year major amputation risk. Our goal was to validate WIfI staging using data from the Best Endovascular vs Best Surgical Therapy in Patients with CLTI (BEST-CLI) trial.

Methods: Data from the BEST-CLI Trial, a prospective randomized trial comparing surgical revascularization (OPEN) and endovascular revascularization (ENDO), were used to assess the association of WIfI stage on long-term outcomes in an intention-to-treat analysis.

Gender-modulated influence of BDNF concentration and Val66Met polymorphism on cognitive outcomes in chronic limb ischemia patients.

Introduction: While numerous studies have established associations between brain-derived neurotrophic factor (BDNF) and cognitive functioning, limited research has delved into the role of BDNF concerning cognitive outcomes in atherosclerosis-related conditions. This study aimed to investigate the correlations between cognitive performance, serum BDNF levels, and the BDNF Val66Met polymorphism in individuals diagnosed with chronic limb ischemia (CLI).

Participants And Procedure: The study encompassed 159 CLI patients (52 females, 107 males) aged 59-73 years.

Uncovering the pharmacological mechanism and the main herbal medicine contributing to the efficacy of Xiaoyanlidan Tablet (XYLDT) in treating cholestatic liver injury.

Ethnopharmacological Relevance: Xiaoyanlidan Tablet (XYLDT) is a Chinese patent medicine consisted of three traditional Chinese medicines (TCMs) including Andrographis Herba (AH), Linearstripe Rabdosia Herba (LRH) and Picrasmae Ramulus et Folium (PRF). In Chinese traditional medicine theory, XYLDT has the "heat-clearing, dampness-dispelling and gallbladder function promoting" properties, and was widely used in the clinic for decades to treat pain in the subcostal region or bitter taste in the mouth, which were induced by liver-gallbladder dampness-heat. Meanwhile, it was also used for the therapy of acute cholecystitis and cholangitis.

STRprofiler: efficient comparisons of short tandem repeat profiles for biomedical model authentication.

Summary: Short tandem repeat (STR) profiling is commonly performed for authentication of biomedical models of human origin, yet no tools exist to easily compare sets of STR profiles to each other or an existing database in a high-throughput manner. Here, we present STRprofiler, a Python package, command line tool, and Shiny application providing methods for STR profile comparison and cross-contamination detection. STRprofiler can be run with custom databases or used to query against the Cellosaurus cell line database.

Estimating nonlinear anisotropic properties of healthy and aneurysm ascending aortas using magnetic resonance imaging.

An ascending aortic aneurysm is an often asymptomatic localized dilatation of the aorta. Aortic rupture is a life-threatening event that occurs when the stress on the aortic wall exceeds its mechanical strength. Therefore, patient-specific finite element models could play an important role in estimating the risk of rupture.

Resistance Index as a Prognostic Factor for Patency in Distal Lower Limb Arterial Revascularization.

Background: Critical limb ischemia (CLI) of the lower limbs (LLs) is a severe condition caused by peripheral arterial obstructive disease (PAOD). Surgical planning for CLI requires the study of limb circulation, and the vascular resistance index (RI) measured by Doppler ultrasound (US) has been used to aid in surgical decision-making. The objective is to correlate the RI of recipient arteries with the patency of LL revascularization surgeries in patients with CLI.

Hydrogen spillover for boosted catalytic activity towards hydrazine oxidation.

A nanoflower-like MoO-Rh electrocatalyst exhibits a 3.5-fold higher mass activity in the hydrazine oxidation reaction compared with metallic Rh, attributed to the hydrogen spillover, acting as a hydrogen pump to deplete hydrogen from the Rh active site.