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Correlation Between Blue Fundus Autofluorescence and SD-OCT Measurements of Geographic Atrophy in Dry Age-Related Macular Degeneration.
Am J Ophthalmol
October 2024
From The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic (J.P.E., C.M., S.Y., H.C., Y.C., G.K., R.A., J.W., V.W., M.B., J.R., S.K.S.), Cleveland, Ohio, USA; Cole Eye Institute, Cleveland Clinic (J.P.E., C.M., S.Y., H.C., Y.C., G.K., R.A., J.W., V.W., M.B., J.R., S.K.S.), Cleveland, Ohio, USA.
Article Synopsis
- The study compared fundus autofluorescence (FAF) and optical coherence tomography (OCT) measurements of geographic atrophy (GA) to evaluate the effectiveness of avacincaptad pegol (ACP) treatment in a clinical trial called GATHER1.
- A post hoc analysis showed a strong correlation (r = 0.93) between FAF and OCT measurements, indicating that both methods provided similar results in assessing GA area.
- The OCT showed a significant reduction in GA growth between ACP and sham groups at 12 and 18 months, confirming that OCT can be a reliable method for measuring GA in clinical settings.