5 results match your criteria: "Cleveland Clinic & Lerner College of Medicine of Case Western Reserve University[Affiliation]"
Skin tears: state of the science: consensus statements for the prevention, prediction, assessment, and treatment of skin tears©.
Adv Skin Wound Care
September 2011
KDS Professional Consulting, Ottawa, Ontario, Canada.
The appropriate management of patients with skin tears is an ongoing challenge for healthcare professionals. Skins tears are often painful, acute wounds resulting from trauma to the skin and are largely preventable. Healthcare professionals must be able to identify individuals at risk for skin tears and aid in the prevention of these wounds and in their treatment when they occur.
View Article and Find Full Text PDFThe Surgical Treatments Outcomes Project for Dysfunctional Uterine Bleeding: summary of an Agency for Health Research and Quality-sponsored randomized trial of endometrial ablation versus hysterectomy for women with heavy menstrual bleeding.
Menopause
April 2011
Department of Obstetrics, David Geffen School of Medicine at UCLA and Kaiser Permanente Southern California, Los Angeles Medical Center, Los Angeles, CA 90027, USA.
Surgical Treatments Outcomes Project for Dysfunctional Uterine Bleeding is an agency for the Healthcare Research and Quality project built around a multicenter randomized clinical trial comparing hysterectomy and endometrial ablation (EA) for the treatment of heavy menstrual bleeding unrelated to structural causes. For inclusion, women self-defined their complaint, and the endometrial cavity was evaluated to exclude structural lesions. The primary outcomes were bleeding and major problem "solved" at 24 months, with length of institutional stay, surgical complications, quality of life, and reoperation included as secondary outcomes.
View Article and Find Full Text PDFEstimating premorbid IQ in the prodromal phase of a neurodegenerative disease.
Clin Neuropsychol
July 2011
Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.
Article Synopsis
- The study evaluates how well the ANART and WASI tests can estimate premorbid intellect, which helps in assessing cognitive decline in early stages of neurodegenerative diseases.
- Participants included 371 individuals with prodromal Huntington disease and 51 with normal CAG repeats, assessed over four years.
- Results showed ANART had lower performance variability and better test-retest reliability compared to WASI, suggesting it may be a more stable measure for understanding cognitive changes over time.
Detrimental effects of environmental tobacco smoke in relation to asthma severity.
PLoS One
May 2011
Departments of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America.
Background: Environmental tobacco smoke (ETS) has adverse effects on the health of asthmatics, however the harmful consequences of ETS in relation to asthma severity are unknown.
Methods: In a multicenter study of severe asthma, we assessed the impact of ETS exposure on morbidity, health care utilization and lung functions; and activity of systemic superoxide dismutase (SOD), a potential oxidative target of ETS that is negatively associated with asthma severity.
Findings: From 2002-2006, 654 asthmatics (non-severe 366, severe 288) were enrolled, among whom 109 non-severe and 67 severe asthmatics were routinely exposed to ETS as ascertained by history and validated by urine cotinine levels.
Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies.
Thorax
October 2011
Institute for Clinical Researchand Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA.
Article Synopsis
- The study highlights the importance of identifying gene-by-environment interactions in understanding the genetics of chronic obstructive pulmonary disease (COPD), particularly regarding the relationship between smoking exposure and lung function.
- Non-linear relationships between smoking pack-years and forced expiratory volume (FEV(1)) were found in four large cohorts, suggesting that a piecewise linear model is more effective than the standard total pack-years model for analyzing these interactions.
- The research concluded that utilizing approaches that account for non-linearity can enhance the accuracy and power of genetic association studies, leading to better insights into COPD susceptibility and variations based on smoking exposure.