378 results match your criteria: "Clementino Fraga Filho University Hospital.[Affiliation]"

Background: The congenital absence of the left atrial appendage (LAA) is an extremely rare anatomical anomaly, with only 23 cases documented in medical literature. The LAA plays a critical role in thrombus formation, particularly in patients with atrial fibrillation (AF), thus impacting stroke prevention strategies and the management of anticoagulation.

Case Summary: We report a 48-year-old male with a 2-year history of hypertension and prior episodes of tachycardic palpitations, who presented with AF and chest pain.

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Exploring the genetic contribution in obesity: An overview of dopaminergic system genes.

Behav Brain Res

December 2024

Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), 4365 Brazil Avenue, Leônidas Deane Pavilion, Rio de Janeiro, RJ 21040-360, Brazil; Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Professor Rodolpho Paulo Rocco Street, 255, University City, Rio de Janeiro, RJ 21941-617, Brazil. Electronic address:

Article Synopsis
  • Obesity is a growing global health issue linked to lower quality of life and higher health risks, with a rising prevalence in Western countries.
  • Researchers are investigating the role of neurotransmitters, especially dopamine, in influencing food intake and behaviors associated with obesity.
  • Genetic variations affecting dopaminergic processes may contribute to obesity by modifying how the brain responds to food-related rewards, highlighting the importance of understanding genetic factors in managing obesity.
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Aims: To assess whether telemonitoring improves outcomes in patients with chronic heart failure.

Methods And Results: A literature search was conducted on studies of randomized controlled trials involving non-invasive telemonitoring and heart failure using Medline, Embase, and Cochrane Library. The primary outcomes were all-cause mortality, all-cause hospitalization, and hospitalization for heart failure.

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Unmasking self-citations: A critical analysis using maxillofacial surgery literature as example.

J Craniomaxillofac Surg

November 2024

Oral and Maxillofacial Surgery Training Program, Foundation of Dentistry - Fundecto, University of São Paulo, São Paulo, Brazil; Department of Oral and Maxillofacial Surgery, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Bibliometric analysis serves as a potent tool for deciphering the intricacies of scholarly communication and academic impact, contributing to an observable surge in publications of this nature. The objective of this study is to conduct a bibliometric analysis of self-citation in Maxillofacial Surgery (MFS) literature. The retrospective study adheres to the principles outlined in the Leiden Manifesto, utilizing Web of Science and Scopus databases for a robust analysis.

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Study of the Gut Microbiome in Patients with Psoriatic Arthritis.

Eur J Rheumatol

September 2024

Division of Dermatology and Rheumatology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro Faculty of Medicine, Rio de Janeiro, Brazil.

Article Synopsis
  • Gut dysbiosis is thought to be connected to immune-mediated diseases like psoriasis, with this study focusing on the gut microbiome in patients with severe psoriatic disease and those with psoriatic arthritis.
  • The research utilized 16S rRNA gene sequencing to analyze stool samples from 30 patients, revealing significant differences in the gut microbiome composition, particularly an increase in the Bacteroides genus in those with psoriatic arthritis.
  • Although the study highlights these microbiome differences, it notes limitations like the small patient group and ongoing questions about whether gut dysbiosis is a cause or effect of the disease, emphasizing the potential for future interventions.
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Acute Epstein-Barr Virus and SARS-CoV-2 Coinfection: A Case Report.

Curr Health Sci J

September 2024

Postgraduate Program in Dentistry, Universidade do Grande Rio (UNIGRANRIO), Rio de Janeiro, Brazil.

Article Synopsis
  • An 18-year-old female was misdiagnosed with bacterial tonsillitis and treated with antibiotics, but subsequent tests revealed she had a coinfection of Epstein-Barr Virus (EBV) and SARS-CoV-2 (COVID-19).
  • Symptoms included throat pain, cough, and enlarged lymph nodes, while tests indicated active EBV infection and confirmed COVID-19.
  • This case highlights the challenge of diagnosing coinfections and the critical role of proper lab testing to avoid incorrect treatments that could worsen the patient's health.
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Malignant lymphoma is an unusual form of gallbladder neoplasm. Almost all these tumors are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas. Herein, we present a literature review of gallbladder Burkitt's lymphoma (BL) cases that includes also an unpublished case in an HIV-infected child, observed by our center.

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Microsporum audouinii: Emergence of an etiological agent of tinea capitis in Rio de Janeiro, Brazil (2012-2019).

Med Mycol

October 2024

Division of Dermatology, Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, 21941-612Brazil.

Article Synopsis
  • The study highlights a shift in the causes of tinea capitis, particularly due to changing migration patterns, focusing on 19 cases linked to the rare fungus Microsporum audouinii in South America.
  • All patients were male children, averaging 6.1 years old, with the majority residing in Rio de Janeiro.
  • Treatment varied due to medication shortages, with griseofulvin and terbinafine prescribed, but terbinafine led to longer recovery times when switched for some patients, indicating ongoing changes in the region's fungal infections.
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Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease that causes sleep disturbances and worsens quality of life. However, few studies have been conducted on sleep in adults with atopic dermatitis. This study aimed to evaluate sleep and quality of life in adults with AD.

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Context: Diseases related to excessive sugar consumption have become a public health concern. However, there may be a direct association between the consumption of artificial sweeteners and changes in body weight.

Objective: The aim was to evaluate potential industry financial conflicts of interest in publications on the relationship between high-intensity sweetener consumption and changes in body weight in observational and intervention studies.

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and Sequence Variations in Brazilian Asthmatic Patients.

Curr Issues Mol Biol

July 2024

Laboratory of Molecular Biology Applied to Mycobacteria, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, Brazil.

Asthma is a chronic inflammatory respiratory condition, characterized by variable airflow limitation, leading to clinical symptoms such as dyspnea and chest tightness. These symptoms result from an underlying inflammatory process. The β2 agonists are bronchodilators prescribed for the relief of the disease.

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Article Synopsis
  • The study investigated the safety of injecting bone marrow-derived mononuclear cells (BMDMCs) directly into the renal arteries of five patients with severe FSGS, using imaging to track where the cells went in the body.
  • Results showed that the procedure was safe with no serious side effects, and there was a temporary increase in kidney markers, but overall kidney function remained stable during the follow-up period.
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Background: Liver transplantation is used for treating end-stage liver disease, fulminant hepatitis, and oncological malignancies and organ shortage is a major limiting factor worldwide. The use of grafts based on extended donor criteria have become internationally accepted. Oxygenated machine perfusion technologies are the most recent advances in organ transplantation; however, it is only applied after a period of cold ischemia.

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Purpose: Chronotype, which captures a person's daily preferences for activity and sleep, is still a poorly researched area in epilepsy research. Finding common chronotype characteristics in people with epilepsy (PWE) and explaining possible effects on seizure management are the main goals.

Methods: Eleven large-scale investigations from 2010 to 2023 were examined in this scoping review.

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Article Synopsis
  • Obesity is a complex disease linked to various health issues, influenced by how our body stores fat, and some people with obesity don't develop metabolic syndrome.
  • The study recruited 305 individuals with severe obesity and 196 normal-weight controls, collecting various health metrics while analyzing genetic variants associated with fat storage.
  • Results showed that certain gene polymorphisms, particularly rs7895833, rs1467568, and rs660339, were linked to the likelihood of developing severe obesity and associated physical traits, indicating potential genetic markers for obesity risk.
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Congenital midline cervical cleft: Management of a case series and literature review.

J Plast Reconstr Aesthet Surg

June 2024

Department of Surgery - Plastic Surgery Section, Clementino Fraga Filho University Hospital (HUCFF), Federal UFRJ, Rio de Janeiro, Brazil.

Congenital midline cervical cleft is a rare anomaly classified as a malformation of the branchial arches and represents less than 2% of congenital cervical malformations. Its clinical presentation involves cervical midline deformities: cephalic nodular lesion, linear groove with atrophic surface, and/or caudal sinus. Other midline alterations of variable complexity may also be present.

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Article Synopsis
  • The study explores the link between high plasma levels of neurofilament light chain (pNfL) and neurocognitive symptoms in patients with Long COVID, indicating that SARS-CoV-2 can lead to long-term brain effects even after mild illness.
  • A group of 63 Long COVID patients underwent neurocognitive assessments, revealing that those with cognitive issues and fatigue had significantly higher pNfL levels compared to those without these symptoms.
  • The findings suggest that measuring pNfL could help identify individuals at risk for CNS involvement and guide their need for ongoing monitoring and treatment for neurocognitive dysfunction post-COVID.
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TBS correlates with bone density and microstructure at trabecular and cortical bone evaluated by HR-pQCT.

J Bone Miner Metab

May 2024

Division of Endocrinology of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF-UFRJ), Avenida Professor Rodolpho Paulo Rocco 255, 21941-913, Rio de Janeiro, RJ, Brasil.

Introduction: Trabecular bone score (TBS) estimates bone microstructure, which is directly measured by high-resolution peripheral quantitative computed tomography (HRpQCT). We evaluated the correlation between these methods and TBS influence on fracture risk assessed by FRAX.

Materials And Methods: We evaluated 129 individuals (82 women, 43 postmenopausal) 20 to 82.

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The present paper provides a historical context for chaos theory, originating in the 1960s with Edward Norton Lorenz's efforts to predict weather patterns. It introduces chaos theory, fractal geometry, nonlinear dynamics, and the butterfly effect, highlighting their exploration of complex systems. The authors aim to bridge the gap between chaos theory and oral and maxillofacial surgery (OMFS) through a literature review, exploring its applications and emphasizing the prevention of minor deviations in OMFS to avoid significant consequences.

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Frontal facial analysis of female celebrity attractiveness standards through artificial intelligence.

J Craniomaxillofac Surg

June 2024

Department of Oral and Maxillofacial Surgery, University of São Paulo School of Dentistry, São Paulo, SP, Brazil; Private Practice in Oral and Maxillofacial Surgery, São Paulo, SP, Brazil.

Article Synopsis
  • The study examines how the facial aesthetics of female celebrities influence societal standards of attractiveness, utilizing artificial intelligence to analyze profile views.
  • It involved a cohort of 115 female celebrities and identified key facial ratios, revealing racial variations in features, such as a general mean golden ratio that differed among African, Asian, Latin, and Caucasian celebrities.
  • The research concluded that while facial symmetry is desirable, it is not essential; instead, specific ratios and angles, like a zygomatic-to-mandibular width ratio close to 80% and a chin angle of approximately 138°, define an attractive female face across different races.
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Haptic devices as an educational approach for oral and maxillofacial surgical procedures.

J Stomatol Oral Maxillofac Surg

October 2024

Department of Oral and Maxillofacial Surgery, Traumatology and Prosthesis, Dental School of University of São Paulo, São Paulo, SP, Brazil; Private Practice in Oral and Maxillofacial Surgery, São Paulo, SP, Brazil.

Objective: Developing the skills of a proficient surgeon with a deep understanding of force requires extensive training and repetitive practice. Traditionally, dental students and surgical trainees observed and participated in procedures using models, animals, or cadavers under expert supervision before performing the procedures independently. To address these challenges, interactive simulators with visuo-haptic features have been introduced in surgical training, providing visual and tactile feedback that replicates the sense of touch through applied forces, vibrations, or motions.

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Objective: Vitamin D (VD) is a fat-soluble steroid hormone, synthesized by the skin, most known for its role in bone mineral balance. Vitamin D receptors (VDR) are also found in the female reproductive system, but their role remains unclear. The objective of this study was to analyze the relationship between serum vitamin D levels and the number of oocytes retrieved after ovarian stimulation.

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Introduction: Significant evidence suggests that plasma-rich in growth factors (PRGF) favor the repair of chronic wounds, enabling a rapid return to functionality. However, components of PRGF and their effects on persistent ulcers and epithelial tissues are not well characterized. The goals of this research were to analyze the biological properties of platelet-derived factors, to examine their effectiveness on healing of venous ulcers, and to establish a correlation with clinical and sociodemographic data.

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Background/aims: Longitudinal studies assessing the impact of genetic polymorphisms on outcomes in patients with Type 2 Diabetes Mellitus (T2DM) and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) are scarce. This study aimed to evaluate the effect of PNPLA3 and TM6SF2 risk alleles on hepatic and extrahepatic outcomes in T2DM-MASLD individuals.

Methods: Patients' polymorphisms were analysed as follows: PNPLA3 CC, CG and GG; TM6SF2 CC and CT + TT; combined comparing no mutant allele, one allele G or T or ≥2 alleles G or T.

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