Synthesis of -glycosyl amides: conformational analysis and evaluation as inhibitors of β-galactosidase from .

The synthesis of -glycosyl amides typically involves the use of glycosyl amines as direct precursors, resulting in low yields due to hydrolysis and the loss of stereocontrol through anomerization processes. In this study, a sequential synthesis of -glycosyl amides is proposed, employing glycosyl amines as intermediates obtained from glycosyl azides. Derivatives with , , or configurations were synthesized.