Development of nano- and microdevices for the next generation of biotechnology, wearables and miniaturized instrumentation.

This is a short communication based on recent high-impact publications related to how various chemical materials and substrate modifications could be tuned for nano- and microdevices, where their application for high point-of-care bioanalysis and further applications in life science is discussed. Hence, they have allowed different high-impact research topics in a variety of fields, from the control of nanoscale to functional microarchitectures embedded in various support materials to obtain a device for a given application or use. Thus, their incorporation in standard instrumentation is shown, as well as in new optical setups to record different classical and non-classical light, signaling, and energy modes at a variety of wavelengths and energy levels.

FTIR product study of the Cl-initiated oxidation products of CFC replacements: (/)-1,2,3,3,3-pentafluoropropene and hexafluoroisobutylene.

A product study of the reactions of (/)-1,2,3,3,3-pentafluoropropene ((/)-CFCF[double bond, length as m-dash]CHF) and hexafluoroisobutylene ((CF)C[double bond, length as m-dash]CH) initiated by Cl atoms were developed at 298 ± 2 K and atmospheric pressure. The experiments were carried out in a 1080 L quartz-glass environmental chamber coupled FTIR spectroscopy to monitor the reactants and products. The main products observed and their yields were as follows: CFC(O)F (106 ± 9)% with HC(O)F (100 ± 8)% as a co-product for (/)-CFCF[double bond, length as m-dash]CHF, and CFC(O)CF (94 ± 5)% with HC(O)Cl (90 ± 7)% as a co-product for (CF)C[double bond, length as m-dash]CH.

L-shell ionization of Cd: Structure of the x-ray emission spectrum.

The cadmium L x-ray spectrum induced by electron impact was analyzed in detail. The measurements were performed on a bulk pure sample using a commercial wavelength dispersive spectrometer, and the spectrum was processed with a parameter optimization method previously developed. This procedure permitted the determination of characteristic energies, relative transition probabilities and natural linewidths for this element.

Synthetic non-classical luminescence generation by enhanced silica nanophotonics based on nano-bio-FRET.

Fluorescent silica nanoparticles (NPs-(SiO-Fluo)) were synthesized based on the classical Störber method for cyanobacteria labelling. Modified mono-coloured SiO NPs with fluorescein (Fl) and rhodamine B (RhB) were obtained (NPs-(SiO-Fl) and NPs-(SiO-RhB)). Moreover, multi-coloured SiO NPs, the incorporation of both emitters (NPs-(SiO-RhB-Fl)), were tuned for optimal emissions and the biodetection of cyanobacteria.

Degradation of a series of fluorinated acrylates and methacrylates initiated by OH radicals at different temperatures.

Rate coefficients for the gas-phase reactions of OH radicals with a series of fluorinated acrylates and methacrylates: 2,2,2-trifluoroethylmethacrylate ( ), 1,1,1,3,3,3-hexafluoroisopropylacrylate ( ), 1,1,1,3,3,3-hexafluoroisopropylmethacrylate ( ), and 2,2,2-trifluoroethylacrylate ( ) have been measured for the first time as a function of temperature in the range 290-308 K. The kinetic data obtained were used to derive the following Arrhenius expressions (in units of cm per molecule per s): = (2.13 ± 0.

High-viscosity glass-ionomer vs. composite resin restorations in persons with disability: Five-year follow-up of clinical trial.

The aim of this clinical trial was to compare the 5-year cumulative survival of atraumatic restorative treatment restorations using high-viscosity glass-ionomer restorations (ART/HVGIC) and conventional resin composite restorations (CRT) placed in patients with intellectual and/or physical disability. Patients referred for restorative care to a special care service in Córdoba, Argentina, were recruited. Patients and/or caregivers were provided with written and verbal information regarding treatment options and selected the alternative they preferred.

Designing electrochemical interfaces based on nanohybrids of avidin functionalized-carbon nanotubes and ruthenium nanoparticles as peroxidase-like nanozyme with supramolecular recognition properties for site-specific anchoring of biotinylated residues.

We are reporting an original supramolecular architecture based on a rationally designed new nanohybrid with enhanced peroxidase-like activity and site-specific biorecognition properties using avidin-functionalized multi-walled carbon nanotubes (MWCNTs-Av) and Ru nanoparticles (RuNPs). The nanohybrid-electrochemical interface was obtained by drop-coating of MWCNTs-Av dispersion at glassy carbon electrodes (GCE) followed by solvent evaporation and further electrodeposition of RuNPs (50 ppm RuCl for 15 s at -0.600 V).

Gas-phase degradation of 2-butanethiol initiated by OH radicals and Cl atoms: kinetics, product yields and mechanism at 298 K and atmospheric pressure.

Relative rate coefficients and product distribution of the reaction of 2-butanethiol (2butSH) with OH radicals and Cl atoms were obtained at atmospheric pressure and 298 K. The experiments were performed in a 480 L borosilicate glass photoreactor in synthetic air coupled to a long path "" FTIR spectrometer. The rate coefficients obtained by averaging the values from different experiments were: = (2.

Product distribution and mechanism of the OH initiated tropospheric degradation of three CFC replacement candidates: CHCF[double bond, length as m-dash]CH, (CF)C[double bond, length as m-dash]CH and (/)-CFCF[double bond, length as m-dash]CHF.

The OH radical initiated photodegradation of 2-fluoropropene (CHCF[double bond, length as m-dash]CH), 3,3,3-trifluoro-2-(tri-fluoromethyl)propene ((CF)C[double bond, length as m-dash]CH) and (/)-1,2,3,3,3-pentafluoropropene ((/)-CFCF[double bond, length as m-dash]CHF) has been investigated for the first time using a 1080 L quartz-glass environmental chamber at 298 ± 2 K and atmospheric pressure of synthetic air coupled with FTIR spectroscopy to monitor reactants and products. The major products observed in the OH reaction were CHC(O)F (98 ± 5)% together with HC(O)H (89 ± 7)% as a co-product, CFC(O)F (103 ± 8)% together with HC(O)F (96 ± 7)% as a co-product and CFC(O)CF (91 ± 8)% together with HC(O)H (98 ± 12)% as a co-product from the C-C bond cleavage channel of the intermediate hydroxyalkoxy radical, formed by addition of OH to the terminal carbon of the double bond which is designated C of 2-fluoropropene, (/)-1,2,3,3,3-pentafluoropropene and 3,3,3-trifluoro-2-(tri-fluoromethyl)propene, respectively. The present results are compared with previous studies for the reaction of OH with the separate isomers () and () of 1,2,3,3,3-pentafluoropropene.

[Analysis of over-the-counter medicines’ information and strategies oriented to the community for improving its access and quality.].

Introduction: The Disposición ANMAT 753/2012 states definitions and guidelines about the information that inserts and labels must include in nonprescription drugs (also known as over-the-counter or OTC drugs).

Aim: Aims: to analyze the adequacy to the norm in a sample of OTC drugs; promote and disseminate strategic viable actions for being developed by pharmacists to improve the patient’s information. formulated.

[Strategies to foster an adequate compromise of the pharmacist with respect to over the counter medicines’ advertisement.].

The advertisement has a great influence on the public and, in over the counter medicines (OTC), it can generate health risks on the population if it is misregulated. The aim of this work is to analyze and disclose strategic viable actions emerged from a forum debate during an online course for fostering the pharmacist’s compromise related to OTC advertisement. Methods: A content analysis was carried on, grouping by themes and categories the opinions of community pharmacists participating in a forum debate about OTC advertisement.

Disorder in H-irradiated HOPG: effect of impinging energy and dose on Raman D-band splitting and surface topography.

Disorder was induced in pristine highly oriented pyrolytic graphite (HOPG) by irradiation with H ions with energies of 0.4 MeV and 1 MeV, and doses of 10 ions/cm and 10 ions/cm. Raman spectroscopy was used as the main technique to characterize different samples and gain new insights on the splitting of the D band into two components (D and D), trying to correlate this feature of the vibrational spectrum with the impinging energy and dose.

Atmospheric sink of β-ocimene and camphene initiated by Cl atoms: kinetics and products at NO free-air.

Rate coefficients for the gas-phase reactions of Cl atoms with β-ocimene and camphene were determined to be (in units of 10 cm per molecule per s) 5.5 ± 0.7 and 3.

Characterization of Chronic Mechanical Irritation in Oral Cancer.

. Oral mucosa could host many lesions originated by chronic mechanical irritation (CMI) from teeth or dentures, and it has been proposed as risk factor for oral cancer. Nevertheless, the features of CMI factors in oral cancer and other lesions are not assessed.

A study on fibre addition to gluten free bread: its effects on bread quality and in vitro digestibility.

The aim of this study was to assess the impact of fibre addition on gluten-free (GF) dough properties and bread technological quality, and on protein and starch in vitro digestibility. Soluble (Inulin, In) and insoluble fibres (oat fibre, OF, and type IV resistant starch, RSIV) were used at 5 and 10% substitution levels. Dough firmness increased when insoluble fibres were added, and decreased when In was used.

Activated α -Macroglobulin Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low-Density Lipoprotein Receptor-Related Protein 1.

Distinct modes of cell migration contribute to diverse types of cell movements. The mesenchymal mode is characterized by a multistep cycle of membrane protrusion, the formation of focal adhesion, and the stabilization at the leading edge associated with the degradation of extracellular matrix (ECM) components and with regulated extracellular proteolysis. Both α -Macroglobulin (α M) and its receptor, low density lipoprotein receptor-related protein 1 (LRP1), play important roles in inflammatory processes, by controlling the extracellular activity of several proteases.

Inequality between size and angular momentum for bodies.

A universal inequality that bounds the angular momentum of a body by the square of its size is presented and heuristic physical arguments are given to support it. We prove a version of this inequality, as consequence of the Einstein equations, for the case of rotating axially symmetric, constant density, bodies. Finally, the physical relevance of this result is discussed.

Systemic exposure, tissue distribution, and disease evolution of a high solubility ciprofloxacin-aluminum complex in a murine model of septicemia induced by salmonella enterica serotype Enteritidis.

A new pharmaceutical derivative obtained by stoichiometric complexation of ciprofloxacin (CIP) with aluminum (CIP-complex) has been investigated and reported in this study. Such product has high solubility in the gastrointestinal pH range and was successful in the development of optimized formulations while maintaining its antimicrobial potency. The systemic exposure, tissue distribution, and the disease evolution after given CIP-complex were assessed.

Eudragit E100 as a drug carrier: the remarkable affinity of phosphate ester for dimethylamine.

Therapeutic agents containing phosphate groups in their molecules have increasing therapeutic impact. The object of this study was to characterize the cationic polyelectrolyte Eudragit E100 (EuE100) as a carrier for drugs containing phosphate groups, using dexamethasone phosphate (DP) as a model. A series of EuE100-DP complexes was obtained by acid-base reaction in which DP neutralized 12.

Activated α(2) macroglobulin induces matrix metalloproteinase 9 expression by low-density lipoprotein receptor-related protein 1 through MAPK-ERK1/2 and NF-κB activation in macrophage-derived cell lines.

Macrophages under certain stimuli induce matrix metalloproteinase 9 (MMP-9) expression and protein secretion through the activation of MAPK-ERK and NF-κB signaling pathways. Previously, we demonstrated that activated α(2)-macroglulin (α(2)M*) through the interaction with its receptor low-density lipoprotein receptor-related protein 1 (LRP1) induces macrophage proliferation mediated by the activation of MAPK-ERK1/2. In the present work, we examined whether α(2)M*/LRP1interaction could induce the MMP-9 production in J774 and Raw264.

Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and alpha(2)-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies.

The immunolocalization of the low density lipoprotein receptor-related protein 1 (LRP1) and its ligand alpha 2-Macroglobulin (alpha(2)M) was examined in tissues from human donor eyes of normal, diabetic and sickle cell disease subjects. Streptavidin alkaline phosphatase immunohistochemistry was performed with a mouse anti-human LRP1 and rabbit anti-human alpha(2)M antibodies. Retinal and choroidal blood vessels were labeled with mouse anti-human CD34 antibody in adjacent tissue sections.

Differential role of gonadal hormones on kainic acid-induced neurodegeneration in medial amygdaloid nucleus of female and male rats.

Sex hormones contribute to modulating brain functions throughout the life span. It has been suggested that estrogen prevents neuronal loss in different areas of the CNS such as the hippocampus. However there are less consistent data on its effects on the amygdala.

Solubility behavior and biopharmaceutical classification of novel high-solubility ciprofloxacin and norfloxacin pharmaceutical derivatives.

The hydrochlorides of the 1:3 aluminum:norfloxacin and aluminum:ciprofloxacin complexes were characterized according to the Biopharmaceutics Classification System (BCS) premises in comparison with their parent compounds. The pH-solubility profiles of the complexes were experimentally determined at 25 and 37 degrees C in the range of pH 1-8 and compared to that of uncomplexed norfloxacin and ciprofloxacin. Both complexes are clearly more soluble than the antibiotics themselves, even at the lowest solubility pHs.

Huperzia saururus increases memory retention in rats.

Huperzia saururus is reported in Argentinean popular medicine as a memory improver. Chemical studies have shown that the main constituents of the species are Lycopodium alkaloids. On the basis of this information, a purified alkaloid extract was obtained by alkaline extraction of the aerial parts.

Activated alpha(2)-macroglobulin induces cell proliferation and mitogen-activated protein kinase activation by LRP-1 in the J774 macrophage-derived cell line.

The low-density lipoprotein receptor-related protein-1 (LRP-1) is an endocytic receptor of activated forms of the proteinase inhibitor alpha(2)-macroglobulin (alpha(2)M*). It has been proposed that alpha(2)M* and LRP-1 modulate diverse cellular processes, including cell adhesion, proliferation, and migration, which are involved in inflammation and tumor progression. However, relatively little is known about the role of alpha(2)M*/LRP-1 interaction on these processes.