1 results match your criteria: "City of Hope-Beckman Research Institute Duarte[Affiliation]"
Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models.
Nanomedicine
April 2017
Department of Stem Cell and Developmental Biology, City of Hope-Beckman Research Institute Duarte, California, USA. Electronic address:
Article Synopsis
- Epithelial ovarian cancer (EOC) is a highly lethal cancer due to late diagnosis and recurring drug resistance, prompting the need for innovative treatments.
- TWIST, a transcription factor associated with cancer progression and resistance, is identified as a promising target for therapy.
- The study shows that TWIST siRNA delivered by nanoparticles can effectively reduce drug resistance and tumor burden in EOC, suggesting a potential strategy for managing metastatic and resistant cancers.