[Impaired hemostasis in elderly and senile patients with mesenteric thrombosis in COVID-19.].

In the treatment of coronavirus infections, it is important not only to understand the course of the disease, but also to understand what is happening in the human body, especially in the circulatory system, that is, which disorders lead to deterioration and further complications. Hemostasis disorder in COVID-19 plays an important role in the etiology and clinical manifestations of the disease. The ability to identify factors and risk groups for the development of thrombotic complications, the ability to dynamically interpret peripheral blood parameters and coagulograms, knowledge of diagnostic criteria for possible hemostasis disorders (for example, DIC syndrome, sepsis-associated coagulopathy, antiphospholipids, hemophagocytosis and hypercoagulation syndrome) are necessary to determine the indications for the test.

[Fibrophysematous lung changes and microbiota changes in senile persons.].

Research on the condition of the lungs in senile people is an urgent task. This is due to the fact that degenerative or age-associated changes in the respiratory system play an important role in the formation of senile asthenia syndrome and a decrease in the age-related viability of the body as a whole. CT-scans of patients aged 80-90 years were analyzed (n=31).

Construction of deep learning-based convolutional neural network model for automatic detection of fluid hysteroscopic endometrial micropolyps in infertile women with chronic endometritis.

Objective(s): Chronic endometritis (CE) is a localized mucosal inflammatory disorder associated with female infertility of unknown etiology, endometriosis, tubal factors, repeated implantation failure, and recurrent pregnancy loss, along with atypical uterine bleeding and iron deficiency anemia. Diagnosis of CE has traditionally relied on endometrial biopsy and detection of CD138(+) endometrial stromal plasmacytes. To develop a less invasive diagnostic system for CE, we aimed to construct a deep learning-based convolutional neural network (CNN) model for the automatic detection of endometrial micropolyps (EMiP), a fluid hysteroscopy (F-HSC) finding recognized as tiny protrusive lesions that are closely related to this disease.

PREDICTORS OF MULTIFOCAL PAPILLARY THYROID CANCER. DO THEY EXIST?

Unlabelled: The aim of this study is to analyze and identify the main predictors that may indicate multifocal growth of PTC.

Materials And Methods: The main and control groups included patients with the category of malignant multifocal process T1-3mN0Mx (n=109) and unifocal T1-T3N0Mx (n=50) respectively, who underwent thyroidectomy with lymphadenectomy.Ultrasound characteristics of the nodes, tissue changes of the thyroid gland were taken into account.

Incidence and mortality rates of strokes in Kazakhstan in 2014-2019.

There is a lack of information on the epidemiology of acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in developing countries. This research presents incidence and mortality rates of stroke patients based on hospital admission and discharge status in one of the Central Asian countries by analysis of large-scale healthcare data. The registry data of 177,947 patients admitted to the hospital with the diagnosis of stroke between 2014 and 2019 were extracted from the National Electronic Health System of Kazakhstan.

Accuracy of ultrasound in estimating fetal weight in New Zealand.

Introduction: Ultrasound estimation of fetal weight is an important factor guiding antenatal management. We aimed to review the accuracy of ultrasound in predicting fetal weight and birthweight category and identify influencing factors.

Methods: We performed a retrospective study of term pregnant women who underwent ultrasound within 7 days of delivery at National Women's Health between January 2019 and January 2020.

THE RESULTS OF THE STUDY OF THE EPIDEMIOLOGICAL STATUS AND SPREAD OF DERMACENTOR RETICULATUS TICKS IN UKRAINE OVER THE LAST 10 YEARS.

Objective: The aim: To analyze the study of the D. reticulatus ticks epidemiology and to carry out their own examinations of ticks for their infection with pathogens of infectious diseases.

Patients And Methods: Materials and methods: Identification of ticks was performed by an optoelectronic SEO system - IMAGLAB.

[Long-term results of radical surgery treatment of patients with bladder cancer].

Purpose: To investigate long-term results after radical cystectomy in patients with bladder cancer.

Materials And Methods: Since 1997 to 2020 yy. we have performed 404 radical cystectomy with different methods of derivation for patients with bladder cancer in our clinic.

[The influence of pseudoexfoliation syndrome on central retina in elderly patients.].

to evaluate the effect of pseudoexfoliation syndrome (PXF) on the stage of age-related macular degeneration (AMD) and central retinal thickness, measured by optical coherence tomography (OCT) in elderly patients living in Saint-Petersburg. 25 elderly patients (30 eyes) with PXF and 25 age-matched patients (29 eyes) without PXF (control group) were included in the study. Retinal thickness in fovea and parafovea as well as AMD stage were compared in the groups.

[Features of the coefficient of variation of hematological indicators in persons of middle, elderly and senile age with pneumonia.].

Pneumonia is the leading mortality rate among all infectious diseases. It has been established that the reliable risk group for morbidity and mortality from this nosology includes persons over 60 years of age, and with age the severity of the disease only increases. According to literary data, one of the reasons for the decline in adaptation capabilities of older persons is the phenomenon of «age desinhronosis», which manifests itself in significant fluctuations in the parameters of the internal environment of the body.

Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution.

Limited knowledge exists on immune markers associated with disease severity or recovery in patients with coronavirus disease 2019 (COVID-19). Here, we elucidated longitudinal evolution of SARS-CoV-2 antibody repertoire in patients with acute COVID-19. Differential kinetics was observed for immunoglobulin M (IgM)/IgG/IgA epitope diversity, antibody binding, and affinity maturation in "severe" versus "mild" COVID-19 patients.

A patient with superior mesenteric artery lymph node metastasis after laparoscopic gastrectomy for gastric cancer with Adachi type VI vascular anomaly: A case report.

Introduction: Due to recent advances in surgical procedures and instruments, laparoscopic gastrectomy for gastric cancer has been widely performed, and previous studies reported laparoscopic surgery for gastric cancer with Adachi type VI vascular anomaly. In Adachi type VI patients, the common hepatic artery (CHA) originates from the superior mesenteric artery (SMA); therefore, the route of lymph flow differs from the normal route, and the supra- and infrapyloric lymph nodes (LN) may reach SMA LN. However, metastasis has not yet been reported.

[Age and nosological structure of ophthalmological diseases of patients of the ophthalmological center of Saint-Petersburg in 2015-2019.].

About 1,3 billion people live on our planet with visual disorders such as cataract and glaucoma, the prevalence of which is significantly higher in the elderlypopulation. Eye diseases remain a global medical, social and economic problem, associated with both the progression of the disease to blindness and the lack of pathogenetic therapy methods. A retrospective analysis of the long-term dynamics and structure of cases of ophthalmological diseases of patients treated in a large multidisciplinary hospital was carried out.

[Features of the picture of blood cells in elderly persons with primary open-angle glaucoma.].

Around 1,3 billion people live worldwide with visual analyzer disorders such as glaucoma and cataract. These diseases are particularly common among the elderly. From glaucoma every year 10 million people completely lose vision, one of the factors of which is untimely diagnosis.

[Laboratory predictors of glaucoma in patients with middle and old age - a tool to improve the quality of life (literature review).].

There are about 1,3 billion people worldwide with visual disorders such as cataract and glaucoma, the prevalence of which is significantly higher in elder persons. Eye diseases remain a global medical, social and economic problem, associated with both the progression of the disease up to blindness and the lack of pathogenetic therapy methods. Timely detection of pathology is secondary prevention of glaucoma.

[Personified monitoring of acute coronary syndrome and its outcomes in elderly patients. Angina. Heart failure (overview).].

Review is about current information on the features of heart failure and angina diagnosis and monitoring in elderly and senile patients. One of the main problem in patients over 65 years is comorbidity, which requires corrective action in the risk stratification and prediction of clinical outcomes. The priority of non-invasive diagnostic tests is noted.

An investigation of the association between ADRB2 gene polymorphisms and asthma in Kazakh population.

Introduction: Beta-2-adrenergic receptor (ADRB2) is present in the cells of the respiratory tract, including bronchial smooth muscle cells and bronchial epithelium, and is a target for endogenous catecholamines and drugs used to treat the obstructive lung diseases.

Objectives: This study aimed to investigate the possible association of the Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene with asthma and its endophenotypes in the Kazakh population.

Methods: A total of 70 asthmatic patients and 80 healthy controls were genotyped for Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene by using quantitative real-time polymerase chain reaction.

Acute sensorimotor polyneuropathy as an early sign of polyarteritis nodosa. A case report.

We examined a patient aged 31 who had a sudden burning paraesthesia, pain and numbness in the lower legs together with an increased temperature of 39°C. Clinical examination showed asymmetrical sensory polyneuropathy more clearly seen in the lower legs and the left wrist, with high ESR (up to 44 mm/h), leukocytosis, slight anemia and proteinuria. CSF was normal.

Efficacy of 13-valent pneumococcal conjugate vaccine in healthcare workers.

Aim: To establish the efficacy of 13-valent pneumococcal conjugate vaccine (PCV13) for healthcare workers protection from occupational acquired infection and impact of healthcare staff vaccination on the risk of transmission to patients.

Materials And Methods: Healthcare personnel (n=157 of whom 105 critical care department staff) and 1770 patients of that critical care department observed. Healthcare workers received PCV13.

[Personified monitoring of acute coronary syndrome and its outcomes in elderly patients. Report 2. Invasive diagnostic and treatment methods (review).].

Literature review describes the features of diagnosis and monitoring of elderly and senile patients with coronary heart disease, that will undergoing coronary angiography, percutaneous coronary intervention or coronary artery bypass surgery. Review notes the advantage of the routine invasive strategy in elderly patients with a high risk of NSTEMI. The authors recommend a preliminary assessment of frailty before coronary angiography.

[Personified monitoring of acute coronary syndrome and its outcomes in elderly patients. Report 1. Acute coronary syndrome (overview).].

The overview describes the clinical features of acute coronary syndrome in patients of older age groups. Atypical symptoms present in this cohort very often. It associated with a worse prognosis, partly due to delays in diagnosis, treatment, and insufficiently substantiated drug therapy.

Specific features of immune complexes in patients with sarcoidosis and pulmonary tuberculosis.

Clinical and radiological features of tuberculosis and sarcoidosis are quite overlapping, and therefore, a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sarcoidosis due to the lack of data on the etiology of the disease. The exclusion of tuberculosis in every patient with suspected sarcoidosis is a mandatory stage of diagnosis, especially in countries with a high burden of tuberculosis.