Evaluating the effectiveness of LINE-based health interventions on dietary habits and health perceptions among young women: A pilot randomized controlled trial.

Objective: This study aimed to investigate the potential of LINE, a major messaging app and social media platform in Japan, as an effective tool to enhance the health and dietary behaviors of young Japanese women who face health and dietary challenges.

Methods: A 6-week randomized controlled trial employing an intention-to-treat analysis was conducted on first-year female students (age range, 18-23 years) from one university and two junior colleges in Mie Prefecture. The participants were allocated to either an intervention group (n = 54) or a control (n = 55) group.

Queer- and trans-inclusive faculty hiring-A call for change.

As queer and trans scientists, we face varied and systemic barriers to our professional success, resulting in our relative absence from faculty ranks at many institutions. In this Perspective, we call for a change in faculty hiring practices and present concrete guidance to make it a more inclusive process.

LC-MS, NMR analysis, molecular docking and simulation studies of phytoestrogen from L. pods against PPAR-α protein.

The present investigation is subjected to comprehensive phytoestrogen analysis from pre-winter and winter seasonal pods using LC-MS and NMR. The analysis of the extracts revealed the presence of many phytoestrogens. Furthermore, molecular docking studies were employed for the investigation of the interactions between the isolated phytoestrogens and PPAR-α.

Cellular signatures in human blood track bone mineral density in postmenopausal women.

Osteoclasts are the sole bone-resorbing cells and are formed by the fusion of osteoclast precursor cells (OCPs) derived from myeloid lineage cells. Animal studies reveal that circulating OCPs (cOCPs) in blood travel to bone and fuse with bone-resident osteoclasts. However, the characteristics of human cOCPs and their association with bone diseases remain elusive.

Variations in kinase and effector signaling logic in a bacterial two component signaling network.

The general stress response (GSR) protects bacteria from a wide range of stressors. In , GSR activation is coordinated by HWE/HisKA2 family histidine kinases (HKs), which can exhibit non-canonical structure and function. For example, while most light-oxygen-voltage sensor-containing HKs are light activated dimers, the RT-HK has inverted "dark on, light off" signaling logic with a tunable monomer/dimer equilibrium.

Data cleaning and harmonization of clinical trial data: Medication-assisted treatment for opioid use disorder.

Several large-scale, pragmatic clinical trials on opioid use disorder (OUD) have been completed in the National Drug Abuse Treatment Clinical Trials Network (CTN). However, the resulting data have not been harmonized between the studies to compare the patient characteristics. This paper provides lessons learned from a large-scale harmonization process that are critical for all biomedical researchers collecting new data and those tasked with combining datasets.

Frequency-dependent phase entrainment of cortical cell types during tACS: computational modeling evidence.

Objective: Transcranial alternating current stimulation (tACS) enables non-invasive modulation of brain activity, holding promise for clinical and research applications. Yet, it remains unclear how the stimulation frequency differentially impacts various neuron types. Here, we aimed to quantify the frequency-dependent behavior of key neocortical cell types.

Elevational Range Impacts Connectivity and Predicted Deme Sizes From Models of Habitat Suitability.

In integrative distributional, demographic and coalescent (iDDC) modelling, a critical component is the statistical relationship between habitat suitability and local population sizes. This study explores this relationship in two Enyalius lizard species from the Brazilian Atlantic Forest: the high-elevation E. iheringii and low-elevation E.

Bridging Implementation Science and Human-Centered Design: Developing Tailored Interventions for Healthier Eating in Restaurants.

Restaurants are important institutions in the communities' economy with the potential to promote healthier foods but have been under-engaged in public health nutrition efforts. In particular, independently owned, minority-serving and minority-owned restaurants, remain under-represented in nutrition promotion efforts despite disproportionate burdens of diet-related health outcomes among minority populations. Addressing this gap in engagement, we undertook a process of co-designing and implementing healthy eating-focused interventions in two Latin American restaurants in New York City, combining the Behavior Change Wheel intervention development framework with a Human-Centered Design approach.

Evaluating anti-inflammatory and anti-oxidative potentialities of the chloroform fraction of Asparagus racemosus roots against cisplatin induced acute kidney injury.

Ethnopharmacological Relevance: Acute kidney injury (AKI), a global public health concern that increases the risk of death, end-stage renal disease, and prolonged hospital admissions. As of this point, supportive measures like fluid resuscitation and replacement therapy for renal failure are the only treatments available for treating AKI. Asparagus racemosus (AR) also known as Shatavari, belongs to family Liliaceae and is considered exceptional in Ayurvedic medicine due to its versatility in treating and preventing a variety of illnesses.

Conversion to Alzheimer's disease dementia from normal cognition directly or with the intermediate mild cognitive impairment stage.

Introduction: Progression to Alzheimer's disease (AD) dementia from normal cognition (NC) can follow different trajectories, with most progressing through a recognizable mild cognitive impairment stage (NC-MCI-AD), while some individuals transition quickly from NC to AD dementia (NC-AD).

Methods: We compared demographic characteristics, health factors, and cognitive and functional assessments across three time points: the first NC visit, the last NC visit, and the first AD dementia visit.

Results: The NC-MCI-AD group showed greater impairment in cognitive and functional scores at AD dementia diagnosis, despite maintaining better cognitive function during the NC stage.

Pesticides' mode of action on aquatic life.

Pesticides are chemical compounds or mixtures of hazardous substances that are used by humans to increase and protect crops from pests and control disease-carrying insects. Because of its wide use, it may be poisonous to helpful and non-targeting plants and animals. Spraying or spreading pesticides over whole fields of crops can cause runoff to transfer the chemicals into aquatic ecosystems, and wind can carry the chemicals to nearby grazing regions, farms, and populated areas, where they can endanger other animals.

How is primary care nursing embedded in nursing undergraduate curricula: A mixed-method study from four countries.

Introduction: Given the increase in the primary care nursing workforce and the need to further grow nursing roles in the community understanding how this is included in undergraduate education is important. This study aimed to explore the inclusion of primary care in the undergraduate nursing education curriculum of four countries.

Method: A mixed-method design was employed to obtain a broader context of primary care nursing in nursing education and teaching approaches relating to primary care nursing.

New Insights Into The Melanin Structure Of .

is a filamentous fungus with a global distribution, manifesting particularly higher prevalence in human-impacted environments. This organism is associated with a wide spectrum of human infections, especially in immunosuppressed individuals, for whom it causes severe and debilitating illnesses with high morbidity and mortality that are compounded by its pan-resistant profile with respect to antifungal drugs. Melanin is a ubiquitous pigment among fungi with a broad range of actions that include promoting fungal virulence.

The effect of neuroticism on mobile phone addiction among undergraduate nursing students: a moderated mediation model.

Background: Mobile phone addiction (MPA) has numerous deleterious effects on college students, including depression, anxiety, cognitive impairments, and sleep disorders. Undergraduate nursing students play a crucial role as a significant reserve workforce in clinical nursing practice, and their compromised mental health status significantly influences the quality of nursing work and nurse-patient relationships in the future.

Objectives: This study aims to investigate the associations between neuroticism and MPA among undergraduate nursing students, the mediating effect of self-control and the moderating effect of psychological capital.

The effect of cancer and cancer treatment on attention control: evidence from anti-saccade performance.

Purpose: Cancer and cancer treatment have been associated with cognitive changes in survivorship, with forgetfulness and distractibility reported years post-treatment. Deficits in attention control may explain these difficulties. We assessed breast cancer survivors using a primary measure of attention control, the saccade/antisaccade task, to assess the effects of diagnosis and treatment.

Increasing extreme hourly precipitation risk for New York City after Hurricane Ida.

The remnants of Hurricane Ida caused major damage and death in the United States on September 1st, 2021, and 11 people drowned in flooded basement apartments within New York City (NYC). It was catastrophic because the maximum hourly precipitation intensity, recorded as 3.47 inches (88.

Transport chirality generated by a tunable tilt of Weyl nodes in a van der Waals topological magnet.

Chirality - a characteristic handedness that distinguishes 'left' from 'right'-is a fundamental property of quantum particles under broken symmetry intimately connected to their spins. Chiral fermions have been identified in Weyl semimetals through their unique electrodynamics arising from 'axial' charge imbalance between pairs of chiral Weyl nodes-the topologically protected 'relativistic' crossings of electronic bands. Chiral magnetotransport phenomena critically depend on the details of electronic band structure.

The impact of inactivation of the GH/IGF axis during aging on healthspan.

Several mouse lines with congenital growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis disruption have shown improved health and extended lifespan. The current study investigated how inactivating this axis, specifically during aging, impacts the healthspan. We used a tamoxifen-inducible global GH receptor (GHR) knockout mouse model starting at 12 months and followed the mice until 24 months of age (iGHRKO mice).

Association of lower serum sclerostin levels with elevated risk for increased arterial stiffness: The JPOS Cohort Study.

Objectives: Studies on the relationship between serum sclerostin, a Wnt/β-catenin pathway inhibitor, and atherosclerosis have yielded inconsistent results. We aim to longitudinally investigate the relationship between serum sclerostin levels and the risk of increased arterial stiffness in Japanese community-dwelling women.

Methods: Of 1044 women aged ≥50 years whose brachial-ankle pulse wave velocity (baPWV) value was available in a baseline survey in 2011-2012, we excluded 374 whose baPWVs were ≥1800 cm/s, set as the cutoff for increased arterial stiffness, and eight with missing data.

Defect Self-Elimination in Nanocube Superlattices Through the Interplay of Brownian, van der Waals, and Ligand-Based Forces and Torques.

Understanding defect healing is necessary to control the electronic and optoelectronic performance of devices based on nanoparticle (NP) superlattices. However, a key challenge remains to understand how NP interactions and the resulting dynamics are coupled to defect self-elimination during assembly processes. Additional degrees of freedom that account for the anisotropic nature of NPs associated with rotational dynamics and torques further complicate the challenge.