Radiologist-Level Performance by Using Deep Learning for Segmentation of Breast Cancers on MRI Scans.

Purpose: To develop a deep network architecture that would achieve fully automated radiologist-level segmentation of cancers at breast MRI.

Materials And Methods: In this retrospective study, 38 229 examinations (composed of 64 063 individual breast scans from 14 475 patients) were performed in female patients (age range, 12-94 years; mean age, 52 years ± 10 [standard deviation]) who presented between 2002 and 2014 at a single clinical site. A total of 2555 breast cancers were selected that had been segmented on two-dimensional (2D) images by radiologists, as well as 60 108 benign breasts that served as examples of noncancerous tissue; all these were used for model training.

A checklist for assessing the methodological quality of concurrent tES-fMRI studies (ContES checklist): a consensus study and statement.

Low-intensity transcranial electrical stimulation (tES), including alternating or direct current stimulation, applies weak electrical stimulation to modulate the activity of brain circuits. Integration of tES with concurrent functional MRI (fMRI) allows for the mapping of neural activity during neuromodulation, supporting causal studies of both brain function and tES effects. Methodological aspects of tES-fMRI studies underpin the results, and reporting them in appropriate detail is required for reproducibility and interpretability.

Differential effects of vascular endothelial growth factor on glycocalyx of endothelial and tumor cells and potential targets for tumor metastasis.

On the surface of every mammalian cell, there is a matrix-like glycocalyx (GCX) consisting of proteoglycans and glycosaminoglycans (GAGs). Disruption of endothelial cell (EC) GCX by a vascular endothelial growth factor (VEGF, VEGF-A), a tumor secretion, was found to be an early event in tumor cell (TC) metastasis across vascular barriers. However, how the TC secretion VEGF affects its own GCX is unknown.

Special Issue: Application of SERS for Nanomaterials.

Surface-enhanced Raman scattering (SERS) is now a relatively mature field of spectroscopy, with it having been almost 50 years since its first experimental demonstration [...

Activated carbon versus metal-organic frameworks: A review of their PFAS adsorption performance.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a class of fluorinated aliphatic compounds considered as emerging persistent pollutants. Owing to their adverse effects on human health and environment, efficient methods of their removal from various complex matrices need to be developed. This review focuses on recent results addressing the adsorption of PFAS on activated carbons (AC) and metal-organic frameworks (MOF).

Overcoming Intensity Saturation in Nonlinear Multiple-Quantum-Well Metasurfaces for High-Efficiency Frequency Upconversion.

Engineered intersubband transitions in semiconductor heterostructures featuring multiple quantum wells (MQWs) are shown to support record-high second-order nonlinear susceptibilities. By integrating these materials in metasurfaces with tailored optical resonances, it is possible to further enhance photonic interactions, yielding giant nonlinear responses in ultrathin devices. These metasurfaces form a promising platform for efficient nonlinear processes, including frequency upconversion of low-intensity thermal infrared radiation and harmonic generation, free of phase-matching constraints intrinsic to bulk nonlinear crystals.

Neural responses to natural visual motion are spatially selective across the visual field, with selectivity differing across brain areas and task.

It is well established that neural responses to visual stimuli are enhanced at select locations in the visual field. Although spatial selectivity and the effects of spatial attention are well understood for discrete tasks (e.g.

Temporal Parity-Time Symmetry for Extreme Energy Transformations.

Temporal interfaces introduced by abrupt switching of the constitutive parameters of unbounded media enable unusual wave phenomena. So far, their explorations have been mostly limited to lossless media. Yet, non-Hermitian phenomena leveraging material loss and gain, and their balanced combination in parity-time (PT)-symmetric systems, have been opening new vistas in photonics.

Direct Current Stimulation Disrupts Endothelial Glycocalyx and Tight Junctions of the Blood-Brain Barrier .

Transcranial direct current stimulation (tDCS) is a non-invasive physical therapy to treat many psychiatric disorders and to enhance memory and cognition in healthy individuals. Our recent studies showed that tDCS with the proper dosage and duration can transiently enhance the permeability (P) of the blood-brain barrier (BBB) in rat brain to various sized solutes. Based on the permeability data, a transport model for the paracellular pathway of the BBB also predicted that tDCS can transiently disrupt the endothelial glycocalyx (EG) and the tight junction between endothelial cells.

Topological phonon-polariton funneling in midinfrared metasurfaces.

Topological photonics offers enhanced control over electromagnetic fields by providing a platform for robust trapping and guiding of topological states of light. By combining the strong coupling between topological photons with phonons in hexagonal boron nitride (hBN), we demonstrate a platform to control and guide hybrid states of light and lattice vibrations. The observed topological edge states of phonon-polaritons are found to carry nonzero angular momentum locked to their propagation direction, which enables their robust transport.

Occupational Depression, Cognitive Performance, and Task Appreciation: A Study Based on Raven's Advanced Progressive Matrices.

The Occupational Depression Inventory (ODI) was recently developed to assess depressive symptoms that individuals specifically attribute to their work. Research on the criterion validity of the instrument is still in its infancy. In this study, we examined whether the ODI predicted performance on, and appreciation of, a cognitively challenging test.

Broadband Topological Slow Light through Brillouin Zone Winding.

Topological photonic insulators have attracted significant attention for their robust transport of light, impervious to scattering and disorder. This feature is ideally suited for slow light applications, which are typically limited by disorder-induced attenuation. However, no practical approach to broadband topologically protected slow light has been demonstrated yet.

Quantification of In Vitro Blood-Brain Barrier Permeability.

In vitro blood-brain barrier (BBB) models have been widely used to simulate in vivo models due to their low cost, feasibility, and repeatability. To serve as a valid substitute, the in vitro BBB should have the similar barrier function as that in vivo. This chapter summarizes the detailed methods for quantifying the barrier function, e.

Surfactant and dilatational viscosity effects on the deformation of liquid droplets in an electric field.

Hypothesis: A conducting droplet suspended in an insulating continuous phase, e.g. an aqueous electrolyte in an oil, is deformed by an applied electric field to nonspherical equilibrium shapes, and can even break-up under strong fields.

High-resolution computational modeling of the current flow in the outer ear during transcutaneous auricular Vagus Nerve Stimulation (taVNS).

Background: Transcutaneous auricular Vagus Nerve Stimulation (taVNS) applies low-intensity electrical current to the ear with the intention of activating the auricular branch of the Vagus nerve. The sensitivity and selectivity of stimulation applied to the ear depends on current flow pattern produced by a given electrode montage (size and placement).

Objective: We compare different electrodes designs for taVNS considering both the predicted peak electric fields (sensitivity) and their spatial distribution (selectivity).

Nonlocal topological insulators: Deterministic aperiodic arrays supporting localized topological states protected by nonlocal symmetries.

The properties of topological systems are inherently tied to their dimensionality. Indeed, higher-dimensional periodic systems exhibit topological phases not shared by their lower-dimensional counterparts. On the other hand, aperiodic arrays in lower-dimensional systems (e.

Effects of transcranial direct current stimulation associated with an aerobic exercise bout on blood pressure and autonomic modulation of hypertensive patients: A pilot randomized clinical trial.

The objective of this article was to evaluate the effects of an aerobic exercise bout associated with a single session of anodal transcranial direct current stimulation (tDCS) over the left temporal lobe on blood pressure (BP) and heart rate variability (HRV) in hypertensive people. After met the inclusion criteria, twenty hypertensive people were randomized to active-tDCS or sham-tDCS group. Initially, they provided their sociodemographic data, a blood sample, and went through an evaluation of the cardiorespiratory performance.

Supercapacitance and superinductance of TiN and NbTiN films in the vicinity of superconductor-to-insulator transition.

We investigate the low-temperature complex impedance of disordered insulating thin TiN and NbTiN films in the frequency region 400 Hz-1 MHz in close proximity to the superconductor-insulator transition (SIT). The frequency, temperature, and magnetic field dependencies of the real and imaginary parts of the impedance indicate that in full accord with the theoretical predictions and earlier observations, the films acquire self-induced electronic granularity and become effectively random arrays of superconducting granules coupled via Josephson links. Accordingly, the inductive component of the response is due to superconducting droplets, while the capacitive component results from the effective Josephson junctions capacitances.

Intraoperative detection of human meningioma using a handheld visible resonance Raman analyzer.

To report for the first time the preliminary results for the evaluation of a VRR-LRR™ analyzer based on visible resonance Raman technique to identify human meningioma grades and margins intraoperatively. Unprocessed primary and recurrent solid human meningeal tissues were collected from 33 patients and underwent Raman analysis during surgeries. A total of 1180 VRR spectra were acquired from fresh solid tissues using a VRR-LRR™ analyzer.

Gain-Free Parity-Time Symmetry for Evanescent Fields.

Parity-time (PT) symmetry, satisfied when a system commutes under combined parity and time-reversal operations, enables extreme optical responses in non-Hermitian systems with balanced distributions of gain and loss. In this Letter, we propose a different path for PT symmetry utilizing the evanescent field excitation of anti-PT-symmetric structures, which anticommute with the PT operator and do not necessarily require gain. Beyond offering a robust platform to explore PT symmetry, our study showcases an important link between non-Hermitian physics and near-field interactions, with implications in nanophotonics, plasmonics, and acoustics for nanoimaging, sensing, and communications.

Development and validation of the Brief-Mentalized Affectivity Scale: Evidence from cross-sectional online data and an urban community-based mental health clinic.

Objective: To develop and validate the Brief-Mentalized Affectivity scale (B-MAS), a shorter version of the Mentalized Affectivity Scale (MAS).

Methods: In Study 1 (N = 978), participants from Amazon's Mechanical Turk were administered a battery of questionnaires including the B-MAS and traditional emotion regulation measures. In Study 2 (N = 230), clients from a community clinic completed a separate battery of measures, including the B-MAS, and personality and emotion regulation measures.