Molecular recognition between adenine or 2,6-diaminopurine and copper(II) chelates with N,O2,S-tripodal tetradentate chelators having thioether or disulfide donor groups.

Five novel ternary copper(II) complexes with the N,O2,S-tripodal tetradentate chelators N,N-bis(carboxymethyl)-S-benzylcysteaminate(2-) ion (BCBC) or N,N,N',N'-tetrakis(carboxymethyl)cystaminate(4-) ion (TCC) and adenine (Hade), 2,6-diaminopurine (Hdap), 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen) as co-ligand were synthesized and characterized by X-ray diffraction and other physical methods: [Cu2(BCBC)2(μ2-N3,N7-H(N9)ade)(H2O)2]·H2O (1), [Cu2(BCBC)2(μ2-N7,N9-H(N3)dap)(H2O)2]·4H2O (2), [Cu2(μ2-TCC)(H(N9)ade)2(H2O)2]·10H2O (3), [Cu2(μ2-TCC)(bpy)2]·15H2O (4) and [Cu2(μ2-TCC)(phen)2]·14H2O (5). The crystal structure of H4TCC·3H2O was also determined. All ternary Cu(II) complexes have molecular structures.

Use of biocytin as neuroanatomic tracer in harvested human pancreas: a confocal laser scanning microscopy analysis.

Introduction: To identify central neuroanatomic structure, biocytin labeling has recently been used. To date, there are no bibliographic references about the use of this molecule in investigations of the peripheral nervous system. In the present study, fresh, harvested human pancreas was used to evidence pancreatic innervations by biocytin.