Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption.

Background: Melatonin is a hormone secreted by the pineal gland in a circadian rhythmic manner with peak synthesis at night. Melatonin signalling was suggested to play a critical role in metabolism during the circadian disruption.

Methods: Melatonin-proficient (C3H-f or WT) and melatonin receptor type 1 knockout (MT KO) male and female mice were phase-advanced (6 hours) once a week for 6 weeks.