8 results match your criteria: "Chuzhou Hospital affiliated to Anhui Medical University[Affiliation]"
Retraction Note: microRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis.
J Transl Med
October 2024
Anatomy and Developmental Biology, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Bone marrow stromal cells dictate lanosterol biosynthesis and ferroptosis of multiple myeloma.
Oncogene
May 2024
The Proton Center of Shandong Cancer Institute and Hospital, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, 250117, China.
Article Synopsis
- Ferroptosis, a form of cell death, shows promise in overcoming chemoresistance in multiple myeloma (MM), but the role of bone marrow stromal cells (BMSCs) in this process is not fully understood.
- Research reveals that BMSCs make MM cells more sensitive to ferroptosis by increasing their iron levels, which activates steroid biosynthesis, particularly the production of lanosterol that contributes to reactive oxygen species (ROS) in these cells.
- The interaction between CD40 ligand and CD40 receptor is crucial for this process, as blocking this interaction reduces iron and lanosterol in MM cells, suggesting potential new treatments for patients with resistant MM.
Myeloid sarcoma as the only manifestation in a rare mixed lineage leukemia-fusion-driven acute myeloid leukemia: A case report.
World J Clin Cases
September 2023
Department of Hematology, Chuzhou Hospital affiliated to Anhui Medical University, Chuzhou 239001, Anhui Province, China.
Background: The mixed lineage leukemia (MLL)-eleven-nineteen lysine-rich leukemia (ELL) fusion gene is a rare occurrence among the various MLL fusion genes. We present the first case in which myeloid sarcoma (MS) was the only manifestation of adult MLL-ELL-positive acute myeloid leukemia (AML).
Case Summary: We report a case of a 33-year-old male patient who was admitted in June 2022 with a right occipital area mass measuring approximately 7 cm × 8 cm.
[15q26 deletion syndrome with pure red cell aplastic anemia: a case report].
Zhonghua Xue Ye Xue Za Zhi
June 2023
The First People's Hospital of Chuzhou, Chuzhou Hospital Affiliated to Anhui Medical University, Chuzhou 239001, China.
Genomics of clonal evolution in a rare essential thrombocythemia with coexisting Type 2 CALR and MPL S204P mutations.
Platelets
December 2023
Department of Hematology, Nanjing Drum Tower Hospital Clinical College, Nanjing Medical University, Nanjing, Jiangsu, PR China.
Article Synopsis
- Essential thrombocythemia (ET) with double driver mutations, such as MPL and CALR, is rare, and this study presents a unique case of a patient with both MPL S204P and Type 2 CALR mutations.
- The patient's ET progressed to an accelerated phase just 3.5 months after diagnosis, during which the CALR mutation disappeared and new mutations, including ASXL1 and ETV6, emerged.
- This case emphasizes the importance of using next-generation sequencing (NGS) to screen for additional mutations in ET patients, as it can provide crucial insights into prognosis, especially during disease progression.
Identification and Validation of the Prognostic Panel in Clear Cell Renal Cell Carcinoma Based on Resting Mast Cells for Prediction of Distant Metastasis and Immunotherapy Response.
Cells
January 2023
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, China.
Article Synopsis
- Clear cell renal cell carcinoma (ccRCC) has a rising incidence and often spreads to distant sites; this study aims to identify key immune cells that impact metastasis and patient prognosis.
- Researchers utilized RNA sequencing and identified resting mast cells (RMCs) as significant, leading to the development of a three-gene panel to categorize patients into high-risk and low-risk groups based on their likelihood of metastasis and response to immunotherapy.
- The findings indicate that patients with high-risk ccRCC (lower RMC infiltration and higher tumor mutation burden) are more responsive to specific immunotherapies (anti-PD-1 and anti-CTLA-4), while low-risk patients respond better to anti-PD-L1 treatment
Alarin moderated myocardial hypertrophy via inhibiting cyclic adenosine monophosphate/protein kinase A signaling pathway to attenuate autophagy.
Peptides
December 2021
Department of Cardiology, Chuzhou Hospital Affiliated to Anhui Medical University, Chuzhou, China. Electronic address:
Article Synopsis
- Alarin has the potential to reduce heart failure caused by myocardial infarction by targeting myocardial hypertrophy through the cAMP/PKA signaling pathway.
- In experiments, both in mice and neonatal rat cardiomyocytes, alarin effectively reduced angiotensin II-induced heart hypertrophy and fibrosis while normalizing key cardiac markers.
- The study shows that alarin works by inhibiting increases in cAMP and PKA, ultimately decreasing autophagy related to heart remodeling.
microRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis.
J Transl Med
September 2021
Anatomy and Developmental Biology, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Article Synopsis
- The study investigates the role of microRNA-193-3p (miR-193-3p) in protecting the heart from injury during sepsis in mice, particularly focusing on its interaction with STAT3, a protein involved in inflammation and cell signaling.
- Researchers induced sepsis in mice and manipulated miR-193-3p levels to observe changes in cardiac function, myocardial injury, and inflammatory responses.
- Results showed that increasing miR-193-3p or decreasing STAT3 improved heart function and reduced damage caused by sepsis, suggesting miR-193-3p could be a promising target for sepsis treatment.