Knockdown of EPS8 expression attenuates the proliferation of enzalutamide-resistant prostate cancer cells.

Androgen deprivation therapies, the key treatment options for prostate cancer, have shown resistance and disease progression in many patients receiving these treatments. Therefore, it is crucial to identify new targetable pathways. Epidermal growth factor receptor pathway substrate 8 (Eps8) is one such potential target.

A Crowded Object Counting System with Self-Attention Mechanism.

Traditional object counting systems use object detection methods to count objects. However, when objects are small, crowded, and dense, object detection may fail, leading to inaccuracies in counting. To address this issue, we propose a crowded object counting system based on density map estimation.

Text-image multimodal fusion model for enhanced fake news detection.

In the era of rapid internet expansion and technological progress, discerning real from fake news poses a growing challenge, exposing users to potential misinformation. The existing literature primarily focuses on analyzing individual features in fake news, overlooking multimodal feature fusion recognition. Compared to single-modal approaches, multimodal fusion allows for a more comprehensive and enriched capture of information from different data modalities (such as text and images), thereby improving the performance and effectiveness of the model.

Movement and positioning of a virtual cuboid in 3d space in an augmented reality environment.

Human-virtual object interaction is common in both entertainment and work settings. This study investigated the movement time (MT) and subjective rating of difficulty (SRD) for moving a virtual cuboid in a 3D space. The participants wore an augmented reality (AR) headset, picked up a virtual cuboid, and placed it on an assigned target.

Healthcare failure mode and effect analysis combined service blueprint - Mitigating mass casualty triage in emergency units: A qualitative study.

Introduction: The 24-hour operation of medical emergency units involves crucial first-hand information and medical treatments, which could involve potential complications and disputes if not handled with the utmost professionalism. Effective logistical support and timely activation are crucial in mass casualty triage to prevent systematic treatment issues and chaos.

Objective: This study explores the integration of Healthcare Failure Mode and Effect Analysis (HFMEA) with a service blueprint to mitigate medical risks and enhance mass casualty triage efficiency in emergency units.

Generative Artificial Intelligence (AI) to Uncover Insights From Breast Cancer Patients' Perceptions to Mindfulness-Based Stress Reduction (MBSR) Interventions.

The study's central objective is to harness the power of generative Artificial Intelligence (AI), in particular based on Large Language Models, as a valuable resource for delving deeper into the insights offered by patients with breast cancer (BC) who actively participated in a Mindfulness-Based Stress Reduction (MBSR) program. In a 6-week MBSR program, each session lasted 2 hours and encompassed a range of techniques, including sitting meditation, body scan, Hatha yoga, and walking meditation. A total of 25 participants were enrolled in the study.

Using a Sensor-Embedded Baseball to Identify Finger Characteristics Related to Spin Rate and Pitching Velocity in Pitchers.

Background: Previous investigations have shown a positive relationship between baseball pitching velocity and the kinetic chain involved in pitching motion. However, no study has examined the influence of finger characteristics on pitching velocity and rate of spin via a sensor-embedded baseball.

Methods: Twenty-one pitchers volunteered and were recruited for this study.

Relationship between one-handed push force and subjective rating of force exertion.

Background: Pushing is a typical workplace activity that may result in musculoskeletal disorders (MSDs). A convenient method of assessing the risk of MSDs is to determine the association between the force applied and the subjective rating of force exertion.

Objectives: This study aimed to determine the relationship between the subjective rating of force exertion and the force applied to both a fixed and a movable handle.

Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm.

The current study aimed to determine the safety profile of intra-articular-injected allogeneic adipose-derived mesenchymal stem cells (ADSCs) GXCPC1 in subjects with knee osteoarthritis (OA) and its preliminary efficacy outcome. The 3 + 3 phase I study was designed with two dose-escalation cohorts: low dose (6.7 × 10 GXCPC1, = 5) and high dose (4 × 10 GXCPC1, = 6).

Optimized Sugar-Free Citrus Lemon Juice Fermentation Efficiency and the Lipid-Lowering Effects of the Fermented Juice.

Aging and obesity make humans more prone to cardiovascular and metabolic syndrome diseases, leading to several serious health conditions, including hyperlipidemia, high blood pressure, and sleep disturbance. This study aimed to explore the hypolipidemic effect of fermented citrus lemon juice using a hyperlipidemic hamster model. The sugar-free lemon juice's fermentation was optimized, and the characteristics of fresh and fermented lemon juice (FLJ) were evaluated and compared, which contained polyphenols and superoxide dismutase-like activity.

Observation of photonic Peierls transition for manipulating microwave in metallic diaphragm-array periodic structures.

Peierls transition that modifies electronic band structure has attracted intensive attention in solid state physics. In the present work, we report that a photonic analog of Peierls transition has been observed in a 1-D triangular metal diaphragm array, where the photonic bandgap structures have been designed at will by adjusting periodically metal diaphragm positions. It is shown by the numerical analysis that the transmission and radiation effect of the present periodic metal structure designed through the Peierls transition rule exhibits the behavior significantly different from an original periodic structure with each unit cell containing a metal diaphragm.

An operational maintenance approach for improving physiological monitor by HFMEA process: an empirical case study.

Unlabelled: This study explored the application of healthcare failure mode and effect analysis (HFMEA) to identify and evaluate risk-associated factors in the intensive care unit (ICU) through a clinical-based expert knowledge (decision) for the physiological monitor operational maintenance process.

Methods And Intervention: A mixed qualitative and quantitative proactive approach to explore the HFMEA process by analyzing 20 units of physiological monitors in the ICU. An HFMEA expert team of six people was formed to perform a risk-based analysis and evaluate the potential hazard index, mitigating the hazard scores and risks.

Path Planning and Motion Control of Indoor Mobile Robot under Exploration-Based SLAM (e-SLAM).

Indoor mobile robot (IMR) motion control for e-SLAM techniques with limited sensors, i.e., only LiDAR, is proposed in this research.

Early detection of myocardial ischemia in resting ECG: analysis by HHT.

Background: Exercise electrocardiography (ECG) is a noninvasive test aiming at producing ischemic changes. However, resting ECG cannot be adopted in diagnosing myocardial ischemia till ST-segment depressions. Therefore, this study aimed to detect myocardial energy defects in resting ECG using the Hilbert-Huang transformation (HHT) in patients with angina pectoris.

Factors Affecting Preventive Behaviors for Safety and Health at Work during the COVID-19 Pandemic among Thai Construction Workers.

Occupational health and safety risks are of major concerns in construction industry. The COVID-19 outbreak provides an additional risk that could drastically affect the safety risks and health of construction workers. Understanding the factors that affect the health and safety of construction workers is significant in reducing risky behaviors and enhancing worker preventive behaviors.

Emotion Detection Based on Pupil Variation.

Emotion detection is a fundamental component in the field of Affective Computing. Proper recognition of emotions can be useful in improving the interaction between humans and machines, for instance, with regard to designing effective user interfaces. This study aims to understand the relationship between emotion and pupil dilation.

High-mobility and low subthreshold swing amorphous InGaZnO thin-film transistors byHplasma and neutral oxygen beam irradiation treatment.

In this work, staggered bottom-gate structure amorphous In-Ga-Zn-O (a-IGZO) thin film transistors (TFTs) with high-k ZrOgate dielectric were fabricated using low-cost atmospheric pressure-plasma enhanced chemical vapor deposition (AP-PECVD) withhydrogenation to modulate the carrier concentration and improve interface quality. Subsequently, a neutral oxygen beam irradiation (NOBI) technique is applied, demonstrating that a suitable NOBI treatment could successfully enhance electrical characteristics by reducing native defect states and minimize the trap density in the back channel. A reverse retrograde channel (RRGC) with ultra-high/low carrier concentration is also formed to prevent undesired off-state leakage current and achieve a very low subthreshold swing.

Mental workload assessments of aerial photography missions performed by novice unmanned aerial vehicle operators.

Background: Mental workload is one of the important variables in understanding human performance in drone operation.

Objective: To test the effects of gender, age group, flight route, and altitude on the flight performance and mental workload of the novice drone operators.

Methods: Ten male and ten female participants without prior drone operating experience joined.

Fatigue and Recovery of Muscles for Pulling Tasks.

Manual materials handling (MMH) contributes to musculoskeletal disorders (MSDs) in the workplace. The development and recovery of muscle fatigue are essential in work/rest arrangements for MMH tasks. A pulling experiment, including a muscle fatigue test and a muscle fatigue recovery test, was conducted.

Challenges and Actions of IAQ under COVID-19: A Survey of Taiwanese People's Perception of Epidemic Prevention and Indoor Places Certification.

COVID-19 is still spreading around the world, and the pandemic has awakened the public's attention to environmental cleanliness. This article used an online survey for people living in Taiwan, and a total of 1206 valid questionnaires were collected in October 2021. According to the survey results of Taiwanese people's awareness of and needs for epidemic prevention and IAQ, 94.

Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation.

Background: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have become a promising tool for functional EVs production. This study investigated the efficacy of EVs and its effect on differentiation capacity.

A One-Step, Monolayer Culture and Chemical-Based Approach to Generate Insulin-Producing Cells From Human Adipose-Derived Stem Cells to Mitigate Hyperglycemia in STZ-Induced Diabetic Rats.

The global population of individuals afflicted with diabetes mellitus has been increasing year by year, and this disease poses a serious threat to human health as well as the economies worldwide. Pancreatic or islet transplantations provide one of the most effective and long-term therapies available to treat diabetes, but the scarcity and quality of pancreatic islets limit their use in treatments. Here, we report the development of a one-step, monolayer culture, and chemical-based protocol that efficiently mediates the differentiation of human adipose-derived stem cells (hADSCs) into insulin-producing cells (IPCs).

Interventions for Body Composition and Upper and Lower Extremity Muscle Strength in Older Adults in Rural Taiwan: A Horizontal Case Study.

The purpose of this study was to understand the effects of a physical activity program and high-protein supplementation on body composition and upper and lower extremity muscle strength in male older adults in rural areas. In this study, 60 healthy male older adults (mean age 77.5 ± 4.

Perceived difficulty, flight information access, and performance of male and female novice drone operators.

Background: Unmanned aerial vehicles (UAVs) or drones are becoming popular in both commerce and private usage. Behaviors of novice drone operators are critical to UAV flight safety.

Objectives: This study aims at discovering the perceived difficulty, flight information access frequency, and flight performance of novice drone operators.

The Comparative Effect of Reduced Mindfulness-Based Stress on Heart Rate Variability among Patients with Breast Cancer.

Heart rate variability (HRV) is a powerful tool for observing interactions between the sympathetic and parasympathetic nervous systems. This study evaluated HRV during a mindfulness-based stress reduction (MBSR) program among women with breast cancer after receiving treatment. A quasi-experimental, nonrandomized design was used.