3,994 results match your criteria: "Chung-Ang University College of Medicine.[Affiliation]"
Postoperative complications in patients with Behçet's disease.
Clin Rheumatol
December 2024
Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Objective: To assess the proportion of postoperative complications of various surgeries in patients with Behçet's disease (BD) and compare the risk of surgical complications between BD patients and controls.
Methods: We analyzed 389 BD patients who underwent surgeries at Seoul National University Hospital between January 2003 and December 2019. Controls were 1:1 matched with BD patients based on age at surgery, sex, and type of surgery.
Clinical significance of MRI-measured olfactory bulb height as an imaging biomarker of idiopathic Parkinson's disease.
PLoS One
October 2024
Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Objectives: This study aimed to determine whether the olfactory bulb height (OBH) measured using magnetic resonance imaging (MRI) has clinical utility as an imaging biomarker in the evaluation of patients with idiopathic Parkinson's disease (iPD) through its correlation with movement impairment.
Methods: This retrospective study included cognitively intact patients with suspected parkinsonism. All participants underwent T2-weighted imaging to measure OBH.
Long-term safety and efficacy of MBA-P01 for the treatment of glabellar lines: results from a multicenter, repeated-dose, open-label extension study.
J Dermatolog Treat
December 2024
Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Purpose Following the introduction of new type of botulinum toxin (MBA-P01), a recent phase 3 study demonstrated that MBA-P01 showed comparable efficacy and safety to onabotulinumtoxin A for reducing glabellar lines. The primary objective of this study was to evaluate the long-term safety of repeated MBA-P01 administration for the treatment of glabellar lines.Materials and methods This multicenter, single-group, repeated-dose, long-term open-label extension study evaluated repeated treatment with MBA-P01 (20 U, five treatments over 16 months), with posttreatment evaluation performed up to 52 weeks.
View Article and Find Full Text PDFCD36 deficiency protects lipopolysaccharide-induced sepsis via inhibiting CerS6-mediated endoplasmic reticulum stress.
Int Immunopharmacol
December 2024
Department of Biochemistry, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea. Electronic address:
The type 2 scavenger receptor CD36 functions not only as a long chain fatty acid transporter, but also as a pro-inflammatory mediator. Ceramide is the simple N-acylated form of sphingosine and exerts distinct biological activity depending on its acyl chain length. Six ceramide synthases (CerS) in mammals determine the chain length of ceramide species, and CerS6 mainly produces C16-ceramide.
View Article and Find Full Text PDFRelationships among Dioxin-like Mitochondria Inhibitor Substances (MIS)-Mediated Mitochondria Dysfunction, Obesity, and Lung Function in a Korean Cohort.
Toxics
October 2024
Biomedical Science Institute, Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Article Synopsis
- Mitochondrial dysfunction is linked to obesity and diabetes, with environmental pollutants possibly increasing diabetes risk through dioxin-like substances that affect mitochondrial health and lung function.
- A study of 1371 adults from the Korean Genome Epidemiologic Study found that dioxin-like mitochondria inhibitor substances (MIS) were associated with body mass index (BMI) and lung function, indicating a complex relationship between these factors.
- Results suggested that higher levels of MIS negatively impacted mitochondrial function, which subsequently affected both BMI and lung health, emphasizing the need for better understanding of mitochondrial health in the context of metabolic disorders and aging.
Clinical Manifestations and Adverse Cardiovascular Events in Patients with Cardiovascular Symptoms after mRNA Coronavirus Disease 2019 Vaccines.
Yonsei Med J
November 2024
Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
Article Synopsis
- * Data was collected from 952 patients, revealing a 2.2% incidence of vaccine-related adverse events (11 cases of myocarditis, 10 of pericarditis), most commonly following the Pfizer-BioNTech vaccine.
- * Despite some patients experiencing symptoms and requiring hospitalization, overall prognosis remained favorable for all patients with mRNA-VRCS, with no significant differences noted in emergency room visits or mortality rates.
One-year mortality and associated factors in older hospitalized COVID-19 survivors: a Nationwide Cohort Study in Korea.
Sci Rep
October 2024
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, 06973, Republic of Korea.
Article Synopsis
- This study assessed the 1-year mortality rate for older COVID-19 patients after hospital discharge, using data from the Korean National Health Insurance System.
- Among the 66,810 patients aged 60 and older, 4.9% died within a year after discharge, with factors like age, male sex, and existing health issues linked to higher mortality.
- Vaccination significantly reduced the risk of death in surviving patients, highlighting the protective effect of vaccination over the long term.
Deep learning reconstruction of diffusion-weighted brain MRI for evaluation of patients with acute neurologic symptoms.
Sci Rep
October 2024
Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea.
Article Synopsis
- This study examines the effectiveness of deep-learning (DL) accelerated diffusion weighted imaging (DWI) for patients with acute neurological symptoms, focusing on faster scan times and image quality.* -
- It compares DL-DWI to traditional DWI in a sample of 321 patients, finding both methods had similar diagnostic accuracy and image quality, but DL-DWI had a significantly shorter acquisition time (49 seconds vs. 165 seconds).* -
- The results indicate that while DL-DWI may show more artifacts, it provided better visibility for smaller lesions and achieved comparable performance in detecting brain lesions, suggesting it is a feasible option for clinical use.*
Combining metabolomics and machine learning to discover biomarkers for early-stage breast cancer diagnosis.
PLoS One
October 2024
Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.
Article Synopsis
- There is a crucial demand for improved biomarkers to detect early-stage breast cancer, and combining untargeted metabolomics and lipidomics with advanced data mining may lead to new discoveries.* -
- This study utilized a multimodal omics approach to find and validate biomarkers that can distinguish between breast cancer patients and those with benign tumors, revealing specific lipid and metabolite changes associated with cancer.* -
- The use of machine learning models showed promising results in differentiating cancerous from benign cases, highlighting the potential for metabolic biomarkers to enhance breast cancer screening, though further validation and development for clinical use are needed.*
Editorial: To Stop or Not to Stop, Is It Still a Question? Authors' Reply.
Aliment Pharmacol Ther
December 2024
Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Effect of intravenous versus inhaled anesthetics on blood-brain barrier dysfunction and neuroinflammation in elderly patients undergoing major surgery: study protocol of a randomized controlled trial.
Trials
October 2024
Department of Anesthesiology and Pain Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, 110 Deokan-Ro, Gwangmyeong-Si, Gyeonggi-Do, Republic of Korea.
Article Synopsis
- Postoperative cognitive dysfunction (POCD) significantly impacts patients, particularly the elderly, and is influenced by blood-brain barrier dysfunction and neuronal injury related to anesthesia choices.
- The study involves 154 patients aged 60 and older undergoing major surgeries, randomly assigned to receive either intravenous or inhaled anesthetics, comparing effects on blood-brain barrier integrity and inflammatory markers.
- Key outcomes measured include changes in serum S100β levels, various inflammatory markers, the incidence of delirium, and cognitive function differences between the two anesthetic groups over time.
Association between food consumption and serum aryl hydrocarbon receptor ligand activity among middle-aged Korean adults.
Nutr Res Pract
October 2024
Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea.
Article Synopsis
- The study investigated the link between dietary intake and exposure to endocrine-disrupting chemicals (EDCs) among middle-aged Koreans, focusing on surrogate biomarkers like aryl hydrocarbon receptor ligands (AhRL) and mitochondrial function indicators (MIS-ATP and MIS-ROS).
- Results indicated that fish consumption was positively correlated with higher AhRL levels, suggesting increased EDC exposure, while cruciferous vegetables showed a negative association with AhRL levels and a positive correlation with MIS-ATP levels.
- Overall, higher fish intake appears to increase the risk of EDC-related bioactivity, contrasting with some protective effects of consuming cruciferous vegetables against high AhRL levels.
larvae extract protects against lipopolysaccharides-induced ferroptosis and inflammation by inhibiting acid sphingomyelinase.
Nutr Res Pract
October 2024
Department of Human Ecology, Graduate School, Korea University, Seoul 02841, Korea.
Background/objectives: Inflammation and ferroptosis are implicated in various diseases and lipopolysaccharides (LPS) have been linked with these disorders. Recently, many edible insects, such as larvae (PB) and larvae, have been recommended as alternative foods because they contain lots of nutritional sources. In this study, we explored the potential of PB extract in preventing LPS-induced inflammation and ferroptosis in Hep3B cells.
View Article and Find Full Text PDFClinicians' Knowledge, Attitudes, and Practices Regarding the Management of Functional Gastrointestinal Disorders With Neuromodulators and Psychological Treatment.
J Neurogastroenterol Motil
October 2024
Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.
Article Synopsis
- A study was conducted to explore Korean clinicians' knowledge, attitudes, and practices related to using neuromodulators and psychiatric treatments for functional gastrointestinal disorders (FGIDs).
- The survey included 451 clinicians from various hospital tiers, revealing that while a high percentage recognized the need for these treatments, many were unfamiliar with prescribing neuromodulators and referred few patients for psychiatric care.
- Results indicated a significant gap in knowledge and prescribing practices between primary care clinicians and gastroenterologists, highlighting the need for further education on this topic.
GR113808, a serotonin receptor 4 antagonist, prevents high-fat-diet-induced obesity, fatty liver formation, and insulin resistance in C57BL/6J mice.
BMC Pharmacol Toxicol
October 2024
Department of Family Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, 21565, Republic of Korea.
Background: The burden of nonalcoholic fatty liver disease is increasing, and limited therapeutic drugs are available for its treatment. Serotonin binds to approximately 14 serotonin receptors (HTR) and plays diverse roles in obesity and metabolic complications. In this study, we focused on the function of HTR4 on nonalcoholic fatty liver disease using GR113808, a selective HTR4 antagonist.
View Article and Find Full Text PDFTo treat or not to treat: CUBN-associated persistent proteinuria.
Kidney Res Clin Pract
September 2024
Department of Pediatrics, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Article Synopsis
- - Researchers studied Korean patients with CUBN gene variants linked to persistent proteinuria, which is often linked to kidney damage, but in this case, it appears benign and stable.
- - All identified patients were young, diagnosed around 5 years old, and exhibited isolated proteinuria with no significant health issues or progression to chronic kidney disease over time.
- - The findings support the notion that CUBN-related proteinuria is generally non-threatening, suggesting that physicians should consider this diagnosis in asymptomatic young children presenting with isolated proteinuria.
Association between Intraoperative Electroencephalogram Burst Suppression and Postoperative Delirium: A Systematic Review and Meta-analysis.
Anesthesiology
January 2025
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background: Electroencephalogram burst suppression can be associated with postoperative delirium; however, the results of relevant studies are discrepant. This systematic review and meta-analysis aimed to assess the association between intraoperative burst suppression and postoperative delirium in adult surgical patients.
Methods: PubMed, MEDLINE, Embase, Google Scholar, and the Cochrane Central Register of Controlled Trials were systematically searched and updated in May 2023.
Sex Differences in Chronic Cough Epidemiology: The Korean Cough Study Group.
J Korean Med Sci
October 2024
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
Article Synopsis
- Chronic cough is a common problem, affecting about 9.6% of people worldwide, with more women than men experiencing it.
- A study in South Korea looked at 625 adult patients to see how chronic cough differs between men and women based on age and causes.
- Results showed that women were generally older, more often had asthma-related coughs, and even though the severity was similar, the prevalence of cough increased significantly in women as they got older.
Lack of Fall Prevention Education in Patients Experiencing Fall-Related Hip Fracture: A Qualitative Study.
Geriatr Orthop Surg Rehabil
September 2024
Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Korea.
Article Synopsis
- The study interviewed older Korean patients who fell and broke their hips to understand their awareness and education about fall prevention.
- Before their falls, the patients didn’t think fall prevention was important, but they realized it was important after their injuries.
- Many patients felt guilty and scared after their falls, but some wanted to learn more about staying safe and preventing future falls.*
Therapeutic Performance of Needle Injection Versus Needle-Free Jet Injector System for Polynucleotide Filler in Skin Rejuvenation.
J Cosmet Dermatol
October 2024
Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
Background: Polynucleotide (PN) filler often causes pain and can lead to delivery inaccuracies when applied via intradermal injection using a traditional needle.
Aims: To evaluate the efficacy of treatment and the pain during the procedure using conventional needle injection versus a needle-free jet system for intradermal PN filler application.
Methods: In this split-face clinical trial, 10 Korean subjects were enrolled.
Pulmonary fibrosis followed by severe pneumonia in patients with COVID-19 infection requiring mechanical ventilation: a prospective multicentre study.
BMJ Open Respir Res
October 2024
Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Korea (the Republic of)
Article Synopsis
- After getting COVID-19 pneumonia, some patients develop lung problems like fibrosis, which is a scarring in the lungs.
- Researchers looked at 64 patients who needed help breathing in South Korea and found that more than half had signs of lung fibrosis on their scans.
- They discovered that being male and having a higher initial health score were linked to a greater chance of developing this lung issue.
Allergen Sensitization and Its Association With Allergic Diseases in the Korean Population: Results From the 2019 Korea National Health and Nutrition Examination Survey.
Allergy Asthma Immunol Res
September 2024
Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Article Synopsis
- Allergens, like dust or pet dander, can make people allergic, and in Korea, about 45% of people are sensitized to them.
- The study tested over 2,300 people to see how allergic reactions relate to age and found different patterns for young people and older adults.
- People who are sensitized to allergens have higher chances of getting allergic conditions like skin rashes and sinus issues.
Ten-year trends in lipid management among patients after myocardial infarction in South Korea.
PLoS One
October 2024
Department of Cardiology, Chonnam National University Hospital, Gwangju, Republic of Korea.
Article Synopsis
- Dyslipidemia, a key risk factor for heart attacks, has shown an increase in prevalence among Korean patients from 11.1% to 17.1% between 2011 and 2020 as this study explored trends in its management.
- Over the same period, there was a rise in statin prescriptions from 92.9% to 97.0%, with high-intensity statin use increasing dramatically and greater adoption of drugs like ezetimibe.
- Despite improvements in managing dyslipidemia, with more patients achieving lipid targets, ongoing efforts are crucial to further lower the risk of heart-related complications.*
2024 KSoLA Consensus on Secondary Dyslipidemia.
J Lipid Atheroscler
September 2024
Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Elevated blood cholesterol and triglyceride levels induced by secondary causes are frequently observed. The identification and appropriate handling of these causes are essential for secondary dyslipidemia treatment. Major secondary causes of hypercholesterolemia and hypertriglyceridemia include an unhealthy diet, diseases and metabolic conditions affecting lipid levels, and therapeutic side effects.
View Article and Find Full Text PDFImpact of non-traditional lipid profiles on 1-year vascular outcomes in ischemic stroke patients with prior statin therapy and LDL-C < 100 mg/dL.
Sci Rep
October 2024
Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
Article Synopsis
- This study examined how non-traditional lipid profiles, specifically the LDL/HDL ratio, affect the risk of vascular events within a year in stroke patients already on statins and with low LDL-C levels.
- The analysis included 7028 patients with acute ischemic strokes and found a significant association between higher LDL/HDL ratios and increased risk of recurrent stroke, heart attack, or death after adjusting for other variables.
- The results suggest that even with low LDL-C levels due to statin use, monitoring the LDL/HDL ratio is important to assess residual risk after a stroke.