3,963 results match your criteria: "Chung-Ang University College of Medicine[Affiliation]"

Background: Cumulative evidence consistently shows that anthropometric and body composition measurements are strongly linked to the risk of incident diabetes, typically based on baseline measurements. This study aims to assess whether repeated measurements enhance the prediction of diabetes risk beyond baseline assessments alone.

Methods: We utilized data from a 16-year population-based follow-up cohort within the Korean Genome and Epidemiology Study, comprising 6,030 individuals aged 40 to 69 years at baseline.

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Objectives: To suggest an optimal energy level of virtual monochromatic images (VMIs) in dual-energy CT arthrography of the wrist.

Methods: This retrospective study included 53 patients with wrist CT arthrography. Conventional polychromatic images and VMIs at four energy levels (40 to 70 keV at 10 keV intervals) were obtained.

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Background: The choice of the deep inferior epigastric perforator (DIEP) flap for breast reconstruction has increased. Three-dimensional (3D) models of DIEP flaps have been introduced with advances in 3D technology to assist the tedious intramuscular dissection of the pedicle. This study presents the process of creating an ideal 3D model for a DIEP flap.

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Background: Recently, cough reflex hypersensitivity has been proposed as a common underlying feature of chronic cough in adults. However, symptoms and clinical characteristics of cough hypersensitivity have not been studied amongst phenotypes of chronic cough. This study aimed to compare symptom features, such as cough triggers and associated throat sensations, of cough hypersensitivity in patients with asthmatic chronic cough and those with refractory chronic cough (RCC).

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Neural network-based automated proptosis measurement using computed tomography images for patients with thyroid-associated orbitopathy.

Sci Rep

November 2024

Department of Ophthalmology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, 102 Heukseok-ro, Dongjak-gu, Seoul, 06973, South Korea.

The purpose of this study was to evaluate the clinical feasibility and reliability of a neural network (NN)-based automated proptosis measurement system using computed tomography (CT) images. An automated proptosis measurement system was developed using the CT images of 200 eyes from 100 patients diagnosed with thyroid-associated orbitopathy. We compared the proptosis value obtained from the proposed automated system with the values obtained from the Hertel exophthalmometer and manual measurements of CT slices.

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Background: The incidence of hypotension in parturients with coronavirus disease (COVID-19) undergoing regional anesthesia remains controversial. This study aimed to investigate the incidence of hypotension during spinal anesthesia in parturients infected with COVID-19, as well as to identify associated risk factors.

Methods: This retrospective study compared COVID-19-positive parturients who underwent cesarean section under spinal anesthesia (COVID-19 group) with a control group between January 2017 and June 2022.

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The LabGenius C-CT/NG-BMX assay (LabGenius CT/NG; BIOMEDUX, Gyeonggi, Republic of Korea) is a recently developed real-time PCR assay that can simultaneously detect the sexually transmitted pathogens (CT) and (NG) in genitourinary specimens. We evaluated the analytical performance of this assay in comparison with BD MAX CT/GC/TV (Becton Dickinson, Franklin Lakes, NJ, USA). The results of both assays were in nearly perfect agreement for the detection of CT and NG.

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Article Synopsis
  • * Out of 170,226 patients, only 3361 (1.97%) received APDs, and overall findings showed that APD use was linked to higher mortality rates among these patients, including those without metastasis.
  • * Interestingly, patients with a prior psychiatric history and long-term APD use had lower mortality, while those starting APDs during radiotherapy experienced higher mortality, indicating that the reasons for APD use may play a significant role in patient outcomes.
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Background And Purpose: The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted people's lifestyles, changing sleep patterns. This study investigated changes in sleep patterns and disturbances in South Koreans over the past decade, including during the pandemic.

Methods: We compared data from the Korean Sleep Headache Society Phase I survey (n = 2484; conducted in 2010) and the National Sleep Survey of South Korea 2022 (n = 3729; conducted in 2022), involving participants aged 20-69 years.

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Background/aims: We previously reported that patients with moderate-to-severe ulcerative colitis (UC) often experience common mental disorders (CMDs) such as anxiety and depression, necessitating immediate psychological interventions within the first 4 weeks of diagnosis. In this 3-year follow-up study of the MOSAIK cohort in Korea, we examined the effects of CMDs at initial diagnosis on clinical outcomes and health-related quality of life (HRQoL).

Methods: We examined differences in clinical outcomes (evaluated based on clinical response, relapse, hospitalization, and medication use) and HRQoL (assessed using the Inflammatory Bowel Disease Questionnaire [IBDQ] and Short Form 12 [SF-12]) according to Hospital Anxiety and Depression Scale (HADS) scores at diagnosis.

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Background: Medullary thyroid carcinoma (MTC) has a poorer prognosis than differentiated thyroid cancers; however, comprehensive data on the long-term outcomes of MTC remain scarce. This study investigated the extended clinical outcomes of MTC and aimed to identify prognostic factors.

Methods: Patients diagnosed with MTC between 1980 and 2020 were retrospectively reviewed.

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Article Synopsis
  • Patients undergoing complex high-risk PCI are still at high risk for adverse events despite standard dual antiplatelet therapy (DAPT).
  • The TAILORED-CHIP trial aims to compare a tailored antiplatelet strategy with an early escalation and late de-escalation approach against conventional DAPT.
  • The study's primary focus is on the net clinical outcome, measuring serious events like death, heart attack, stroke, and significant bleeding within 12 months after the procedure.
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The lack of clear definition and classification for "moderate ulcerative colitis (UC)" creates ambiguity regarding the suitability of step-up versus top-down treatment approaches. In this paper, experts address crucial gaps in assessing and managing moderate UC. The Asia-Pacific, Middle East, and Africa Inflammatory Bowel Disease Coalition comprised 24 experts who convened to share, discuss and vote electronically on management recommendations for moderate UC.

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Article Synopsis
  • - The study focused on how parieto-motor paired stimulation affects brain plasticity in patients with writer's cramp (WC) and cervical dystonia (CD) compared to healthy volunteers.
  • - Using paired transcranial magnetic stimulation, researchers found that the stimulation increased motor cortex excitability in WC patients but not in CD patients or healthy individuals.
  • - The results indicate that while the stimulation enhances brain function in WC, it doesn't seem to relate to changes in the connectivity between the posterior parietal cortex and the motor cortex.
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Smoking Cessation and Incident Cardiovascular Disease.

JAMA Netw Open

November 2024

Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.

Importance: The association between smoking cessation and cardiovascular disease (CVD) risk in relation to cumulative smoking exposure remains poorly understood.

Objective: To evaluate the associations among smoking cessation, lifetime smoking burden, and CVD risk according to the number of years elapsed after smoking cessation.

Design, Setting, And Participants: This retrospective cohort study of the Korean National Health Insurance Service database investigated smoking duration and intensity between January 2006 and December 2008.

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Purpose: To examine the discrepancy in breast density assessments by radiologists, LIBRA software, and AI algorithm and their association with breast cancer risk.

Methods: Among 74,610 Korean women aged ≥ 34 years, who underwent screening mammography, density estimates obtained from both LIBRA and the AI algorithm were compared to radiologists using BI-RADS density categories (A-D, designating C and D as dense breasts). The breast cancer risks were compared according to concordant or discordant dense breasts identified by radiologists, LIBRA, and AI.

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Early pulmonary fibrosis-like changes between delta and pre-delta periods in patients with severe COVID-19 pneumonia on mechanical ventilation.

Sci Rep

October 2024

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu 05505, Seoul, Republic of Korea.

Article Synopsis
  • This study investigates pulmonary fibrosis-like changes in critically ill patients with SARS-CoV-2 pneumonia during two different variant periods: delta and pre-delta.
  • Clinical data and chest CT images were analyzed from a total of 184 patients across two time periods, revealing that those infected during the delta variant period displayed more severe fibrosis-like changes.
  • The findings indicate that patients during the delta period had a higher frequency of significant fibrotic changes compared to the pre-delta group, suggesting the delta variant may be associated with worse pulmonary outcomes.
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Postoperative complications in patients with Behçet's disease.

Clin Rheumatol

December 2024

Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Objective: To assess the proportion of postoperative complications of various surgeries in patients with Behçet's disease (BD) and compare the risk of surgical complications between BD patients and controls.

Methods: We analyzed 389 BD patients who underwent surgeries at Seoul National University Hospital between January 2003 and December 2019. Controls were 1:1 matched with BD patients based on age at surgery, sex, and type of surgery.

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Objectives: This study aimed to determine whether the olfactory bulb height (OBH) measured using magnetic resonance imaging (MRI) has clinical utility as an imaging biomarker in the evaluation of patients with idiopathic Parkinson's disease (iPD) through its correlation with movement impairment.

Methods: This retrospective study included cognitively intact patients with suspected parkinsonism. All participants underwent T2-weighted imaging to measure OBH.

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Purpose Following the introduction of new type of botulinum toxin (MBA-P01), a recent phase 3 study demonstrated that MBA-P01 showed comparable efficacy and safety to onabotulinumtoxin A for reducing glabellar lines. The primary objective of this study was to evaluate the long-term safety of repeated MBA-P01 administration for the treatment of glabellar lines.Materials and methods This multicenter, single-group, repeated-dose, long-term open-label extension study evaluated repeated treatment with MBA-P01 (20 U, five treatments over 16 months), with posttreatment evaluation performed up to 52 weeks.

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Article Synopsis
  • Mitochondrial dysfunction is linked to obesity and diabetes, with environmental pollutants possibly increasing diabetes risk through dioxin-like substances that affect mitochondrial health and lung function.
  • A study of 1371 adults from the Korean Genome Epidemiologic Study found that dioxin-like mitochondria inhibitor substances (MIS) were associated with body mass index (BMI) and lung function, indicating a complex relationship between these factors.
  • Results suggested that higher levels of MIS negatively impacted mitochondrial function, which subsequently affected both BMI and lung health, emphasizing the need for better understanding of mitochondrial health in the context of metabolic disorders and aging.
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Article Synopsis
  • * Data was collected from 952 patients, revealing a 2.2% incidence of vaccine-related adverse events (11 cases of myocarditis, 10 of pericarditis), most commonly following the Pfizer-BioNTech vaccine.
  • * Despite some patients experiencing symptoms and requiring hospitalization, overall prognosis remained favorable for all patients with mRNA-VRCS, with no significant differences noted in emergency room visits or mortality rates.
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