66 results match your criteria: "Chung Shan Medical University Taichung[Affiliation]"

This study aimed to address the concerns regarding sustainability and animal welfare that have led to egg shortages. By examining consumer adoption and purchase intention towards plant-based eggs as a viable alternative, this study identifies the key factors influencing consumer interest. The study integrates the Theory of Planned Behavior (TPB) and Value-Attitude-Behavior (VAB) frameworks.

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  • A study assessed how effective statin therapy is in reducing major cardiovascular risks (MACE) for breast cancer patients who have surgery and radiotherapy.
  • Researchers analyzed data from nearly 1,500 patients with early left-sided breast cancer, finding that statin users had significantly lower MACE rates compared to nonusers.
  • Specifically, hydrophilic statins like rosuvastatin and pravastatin provided the greatest benefits, and higher dosages correlated with even lower MACE risks, indicating a need for further research on optimizing statin use in breast cancer survivors.
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Aims: The use of extended criteria donors is a routine practice that sometimes involves extracorporeal membrane oxygenation (ECMO) in donations after cardiac death or brain death.

Methods: We performed a retrospective study in a single center from January 2006 to December 2019. The study included 90 deceased donor liver transplants.

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  • First-generation tyrosine kinase inhibitors (TKIs) work well for NSCLC patients with EGFR mutations, but they often lead to resistance, prompting research into new treatment options.
  • Proscillaridin A showed promise in inhibiting cell growth and movement in NSCLC cells regardless of EGFR mutation status and reduced micrometastasis in animal models.
  • The study highlights that proscillaridin A affects certain signaling pathways related to cell structure and motility, suggesting its potential as a therapy for lung cancer by disrupting EGFR-Src-mediated mechanisms.
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A simple and novel method is proposed for preparation of water-soluble fluorescent carbon dots (C-dots), which have potential to be applied in detecting reactive oxygen species (ROS). The C-dots with high fluorescence quantum yield were created by hydrothermal methods with lactose as the carbon source and tris(hydroxylmethyl)aminomethane (Tris) as the surface passivation reagent. The C-dots have some unique characteristics such as excellent biocompatibility with a broad pH working range of 5-11 and high fluorescence, which makes them especially useful in the bio-detection field.

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A novel application of conventional Ag nanoparticles (NPs) for metal-enhanced fluorescence (MEF) in cellular imaging is proposed. Different molecular weights of polyethylene glycol (PEG) were tested to determine a suitable spacer on Ag NPs for MEF, and NPs comprising Ag with PEG with a molecular weight of 6000 g (Ag-PEG6k), when present in fluorescein solution, were discovered to cause a 2-fold quantum yield enhancement. For fluorescence imaging of mesenchymal stem cells stained by Alexa Fluor 488, the enhancement factor increased with the Ag-PEG6k NP concentration but decreased with the Alexa Fluor 488 concentration.

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Globo-H (GH), a globo-series glycosphingolipid antigen that is synthesized by key enzymes β1,3-galactosyltransferase V (β3GalT5), fucosyltransferase (FUT) 1 and 2, is highly expressed on a variety of epithelial cancers rendering it a promising target for cancer immunotherapy. GH-targeting antibody-drug conjugate has been demonstrated an excellent tumor growth inhibition potency in animal models across multiple cancer types including Gastric cancer (GC). This study aims to further investigate the GH roles in GC.

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  • Aberrant accumulation of chondroitin sulfate (CS) in glioblastoma (GBM) is linked to tumor progression, yet the role of excessive CS and its potential as a drug target remains unclear.
  • The study investigates the biological functions of CHST11, which is found to be overexpressed in GBM tissue, enhancing cell mobility and contributing to aggressive behaviors in GBM cells.
  • Treatment with a C4S-specific binding peptide (C4Sp) shows promise in reducing GBM cell invasiveness and improving survival rates in mice models, suggesting a new approach to targeting abnormal CS in GBM therapy.
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X-linked hypophosphatemia (XLH) is a rare, inherited, multisystem disorder characterized by hypophosphatemia that occurs secondary to renal phosphate wasting. Mutations in PHEX gene (located at Xp22.1) in XLH alter bone mineral metabolism, resulting in diverse skeletal, dental, and other extraskeletal abnormalities that become evident in early childhood and persist into adolescence and adult life.

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In Regard to Gouveia et al.

Int J Radiat Oncol Biol Phys

January 2023

Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.

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  • Liposomal irinotecan (nal-IRI) combined with 5-fluorouracil and leucovorin shows improved survival for pancreatic ductal adenocarcinoma (PDAC) patients after they progress from gemcitabine therapy.
  • A study of 667 patients analyzed the effects of starting doses and escalation of nal-IRI on survival and toxicity, categorizing them into standard and reduced doses with or without escalation.
  • Results indicated that patients with reduced doses followed by escalation had the longest treatment cycles and better overall survival compared to those on standard doses or reduced doses without escalation, although standard doses resulted in higher rates of severe side effects.
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In this paper, silver niobate (AgNbO) material was synthesized by a solid-state reaction. AgNbO was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), UV-visible diffuse reflectance spectroscopy (DRS), and Brunauer-Emmett-Teller (BET) measurement. The photocatalytic activity of AgNbO was investigated in degradation of sulfamethoxazole (SMX) under visible light, which is a widely used antibiotic with significant threats towards health and aquatic organisms.

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Septic shock can aggravate organ dysfunction and even lead to death. (JCo) extract has been experimentally demonstrated to have anti-inflammatory and antioxidant effects. We investigated the anti-inflammatory and antioxidant mechanism of JCo extract in vivo and in vitro.

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  • Liposomal irinotecan combined with 5-fluorouracil and leucovorin shows survival benefits in pancreatic ductal adenocarcinoma (PDAC) but also presents side effects, especially in patients resistant to gemcitabine.
  • The study examined the albumin and neutrophil-to-lymphocyte ratio score (ANS) as a tool to predict survival and safety in 434 PDAC patients treated with nal-IRI + 5-FU/LV.
  • Results indicated that higher ANS scores correlated with worse survival rates and increased treatment-related adverse events, confirming ANS as a significant predictor of outcomes in these patients.
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Citrinin (CTN) is a mycotoxin primarily produced by species. Excess consumption of CTN may lead to nephrotoxicity and hepatotoxicity. A pilot study for commercial production of competitive direct enzyme-linked immunosorbent assay (cdELISA) kit and an immunochromatographic strip (immunostrip) for screening CTN in red yeast rice is established in this study.

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The tyrosine kinase Src plays an essential role in the progression of many cancers and is involved in several epidermal growth factor receptor (EGFR)-mediated signalling pathways. To improve the efficacy of lung cancer treatments, this study aimed to identify novel compounds that can disrupt the Src-EGFR interaction and that are less dependent on EGFR status with wild-type and mutations than other compounds. We used the Src pY419 ELISA as the platform to screen a compound library of more than 400 plant-derived active ingredients and identified peruvoside as a candidate Src-EGFR crosstalk inhibitor.

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An ischemic insult at optic nerve (ON) is followed by detrimental neuroinflammation that results in progressive and long-lasting retinal ganglion cell (RGC) death and vision loss. Icariin was reported to be a safe and effective natural anti-inflammatory drug. Herein, we evaluated the long-term therapeutic effects of a single intravitreal injection of poly(lactide-co-glycolide) PLGA-icariin in a rat model of anterior ischemic optic neuropathy (rAION).

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is a tree species found in Morocco with many clinical benefits in genitourinary, musculoskeletal, and skin systems. Previous studies have reported that extracts of have antioxidant, antimicrobial, and anticancer properties. However, its role in colorectal cancer (CRC) remains unclear.

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Bladder cancer is one of the most frequent cancers among males, and a poor survival rate reflects problems with aggressiveness and chemo-resistance. Accumulating evidence indicates that SIRT1 is involved in bladder cancer tumorigenesis and is positively associated with chemo-resistance and poor prognosis. We recently synthesized water-soluble chemical derivatives of heliomycin, an antibiotic from , and demonstrated that they possess anticancer properties.

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Pulmonary Langerhans cell histiocytosis is a rare disease caused by the proliferation of CD1a-positive histiocyte-like cells infiltrating the lung's interstitial layer. Most cases affect young to middle-aged persons, especially adult heavy cigarette smokers. A 49-year-old male heavy smoker (40 pack-year), with non-productive cough, dyspnoea and desaturation, presented with a right-sided pneumothorax on chest x-ray with total atelectasis.

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Background Fluoroquinolones are first-line antibiotics recommended for the treatment of complicated urinary tract infections (UTIs), with frequent reports of adverse effects of aortic aneurysm (AA) and aortic dissection (AD). We examined whether fluoroquinolones can increase the risk of AA and AD in patients with UTIs in the Taiwanese population. Methods and Results We used the National Health Insurance Research Database to identify patients diagnosed with UTIs under single antibiotic treatment of fluoroquinolones and first-, second-, or third-generation cephalosporins.

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