Triphenylamine-based dicyano fluorophore for the selective detection of hydrazine vapor using cellulose acetate nanofibrous sheet.

A novel triphenylamine-based dicyano fluorophore (compound 2) was successfully synthesized using a Suzuki cross-coupling reaction, followed by a Knoevenagel condensation catalyzed with baker's yeast. Later, compound 2 was combined with the hydrazine vapor of an electrospun nanofiber sheet, depending on its solid condition. In addition, the electrospinning technique was used to create a nanofiber sheet made of cellulose acetate (CA) combined with compound 2.

Bi-enzyme assay coupled with silver nanoplate transformation for insecticide detection.

A novel colorimetric method utilizing a bi-enzyme assay using silver nanoplates (AgNPls) as a direct signal source was developed to enable rapid insecticide detection. This innovative system leverages the generated HO from the consecutive enzyme-catalyzed reactions of acetylcholine hydrolysis and choline oxidation to introduce oxidative etching of AgNPls, transforming them into aggregated silver nanospheres (AgNSs). The morphological transformation of silver nanoparticles could be observed with the naked eye due to the solution's color shifts from pink-violet to blue-violet.

Chemical induces microstructural transformation of pulp fibre to colloidal cellulose for sustainable plant protection.

Cellulose, an environmentally friendly material, is abundantly available in Thailand as pulp and has significant potential for use in sustainable plant protection; however, the raw material is not directly suitable for such applications. To address this, colloidal cellulose with high water dispersibility was synthesised by treating Eucalyptus pulp with sulphuric acid (HSO). The optimised conditions involved a 24 hour treatment, producing colloidal cellulose with an average particle size of 0.

Appraising groundwater quality and probabilistic human health risks from fluoride-enriched groundwater using the pollution index of groundwater (PIG) and GIS: a case study of adama town and its vicinities in the central main Ethiopian rift valley.

This research's main objective is to identify the level of contamination in drinking water in Adama town and its environs by employing PIG, GIS and HHRA. The physical-chemical parameters of groundwater were determined, and the results were compared to regional and global drinking water quality guidelines. The pH of groundwater is alkaline, and the contents of Ca, Na, HCO , and F in the majority of samples surpassed the permissible drinking limit.

New phenanthrenequinones from roots and their anti-inflammatory activity on lipopolysaccharide-activated BV2 microglial cells.

The roots of yielded a total of 17 compounds, comprising two new compounds (1-2), one new natural product (3), and 14 known compounds (4-17). The structures of new compounds were determined through the analysis of their spectroscopic data, including NMR, MS, UV, FT-IR, optical rotation, and CD. The anti-inflammatory activity of the isolated pure compounds was assessed using lipopolysaccharide-activated BV2 microglial cells.

Room temperature synthesis of 3D-nanocrystalline graphitic carbon from biomass-derived sugars, alcohols, and polyphenolic compounds.

Nanocrystalline carbon materials exhibit promising potential for sustainable and high-performance applications in electronics, energy storage, and environmental technologies. While sugars are abundant and renewable, converting them to graphitic carbon usually requires high temperature treatment. Here, we present a groundbreaking approach for synthesizing nanocrystalline carbon from readily available sugars such as glucose, fructose, and sucrose at ambient pressure and temperature.

Ultra-fast green synthesis of a defective TiO photocatalyst towards hydrogen production.

An ultra-fast green synthesis of defective titanium dioxide (TiO) photocatalysts was conducted by the microwave-assisted method using l-ascorbic acid (l-As) as a reducing agent. Effect of l-As concentrations on the chemical-, optical- and photoelectrochemical properties as well as the photocatalytic performance towards the hydrogen (H) production was explored. The obtained TiO nanoparticles (NPs) illustrated the brown fine powders with different brownness levels depending on the concentrations of l-As.

Chitosan-assisted hydrogen adsorption and reversibility of Ni-doped hierarchical carbon scaffolds.

We investigated the effects of chitosan (CS) on the hydrogen adsorption and reversibility of hierarchical carbon scaffold (HCS) loaded with Ni nanoparticles. As size-controllable, stabilizing, and shape-directing agents for the green synthesis of metal nanoparticles of CS, Ni nanoparticles with uniform distribution and shape are deposited onto HCS. The latter results in the superior specific surface area of Ni nanoparticles for hydrogen chemisorption.

CFD simulation of silica dispersion/natural rubber latex mixing for high silica content rubber composite production.

High silica contents rubber composites are favored in the green tire industry for their ability to reduce rolling resistance. However, achieving effective silica dispersion in natural rubber, particularly at high silica content, poses a challenge. In addition, the choice of impeller configuration significantly influences mixing performance, especially in commercial production, which requires large mixing tanks.

Development of NIR light-responsive shape memory composites based on bio-benzoxazine/bio-urethane copolymers reinforced with graphene.

In this work, shape memory polymers (SMPs) were developed from a combination of a bio-based benzoxazine (BZ) monomer and polyurethane prepolymer (PU-prepolymer), both derived from bio-based raw materials. The bio-based BZ monomer (V-fa monomer) was synthesized through a Mannich condensation reaction using vanillin, paraformaldehyde, and furfurylamine. The bio-based PU-prepolymer was obtained by reacting palm oil polyol (MW = 1400 Da) and toluene diisocyanate (TDI).

Improving the thermostability and modulating the inulin profile of inulosucrase through rational glycine-to-proline substitution.

The flexibility of protein structure plays a crucial role in enzyme stability and catalysis. Among the amino acids, glycine is particularly important in conferring flexibility to proteins. In this study, the effects of flexible glycine residues in 121 inulosucrase (LrInu) on stability and inulin profile were investigated through glycine-to-proline substitutions.

Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) as an insulin carrier in silk fibroin hydrogels for transdermal delivery iontophoresis.

In this study, silk fibroin (SF) was utilized as the starting material to fabricate physically crosslinked hydrogels. Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) was synthesized and characterized as a drug carrier, with insulin as the model drug. PEDOT:PSS, with a high electrical conductivity of 1666 ± 49 S cm, interacted with insulin molecules electrostatic interaction by replacing the dopant PSS molecules.

Mol-Zero-GAN: zero-shot adaptation of molecular generative adversarial network for specific protein targets.

Drug discovery is a process that finds new potential drug candidates for curing diseases and is also vital to improving the wellness of people. Enhancing deep learning approaches, , molecular generation models, increases the drug discovery process's efficiency. However, there is a problem in this field in creating drug candidates with desired properties such as the quantitative estimate of druglikeness (QED), synthetic accessibility (SA), and binding affinity (BA), and there is a challenge for training a generative model for specific protein targets that has less pharmaceutical data.

Bio-guided isolation of alpha-glucosidase inhibitory compounds from Vietnamese liverwort : and studies.

Bio-guided isolation was applied to Vietnamese L. to find alpha-glucosidase inhibition. Fifteen compounds were isolated and structurally determined, including two new compounds, marchatoside (7) and marchanol (8), along with thirteen known compounds: marchantin A (1), isoriccardin C (2), riccardin C (3), marchantin K (4), lunularin (5), 3-(3,4-dimethoxybenzyl)-5,7-dimethoxyphthalide (6), vitexilactone (9), 12-oleanene-3-one (10), 3,11-dioxoursolic acid (11), ursolic acid (12), artemetin (13), kaempferol (14), and quercetin (15).

Design of electron-donating group substituted 2-PAM analogs as antidotes for organophosphate insecticide poisoning.

The use of organophosphate (OPs) pesticides is widespread in agriculture and horticulture, but these chemicals can be lethal to humans, causing fatalities and deaths each year. The inhibition of acetylcholinesterase (AChE) by OPs leads to the overstimulation of cholinergic receptors, ultimately resulting in respiratory arrest, seizures, and death. Although 2-pralidoxime (2-PAM) is the FDA-approved drug for treating OP poisoning, there is difficulty in blood-brain barrier permeation.

Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: and studies.

Sorafenib (SOR) is an oral multikinase inhibitor that effectively hampers the growth and spread of cancer cells by targeting angiogenesis and proliferation. However, SOR tablets (Nexavar) have limited oral bioavailability, ranging from 38% to 49%, due to their low water solubility. To address this issue, cyclodextrins (CDs), widely used to enhance the solubility and stability of lipophilic drugs by encapsulating them within their molecular structure, were considered in this study.

iEdgeDTA: integrated edge information and 1D graph convolutional neural networks for binding affinity prediction.

Artificial intelligence has become more prevalent in broad fields, including drug discovery, in which the process is costly and time-consuming when conducted through wet experiments. As a result, drug repurposing, which tries to utilize approved and low-risk drugs for a new purpose, becomes more attractive. However, screening candidates from many drugs for specific protein targets is still expensive and tedious.

Molecular adsorption and self-diffusion of NO, SO, and their binary mixture in MIL-47(V) material.

The loading dependence of self-diffusion coefficients () of NO, SO, and their equimolar binary mixture in MIL-47(V) have been investigated by using classical molecular dynamics (MD) simulations. The of NO are found to be two orders of magnitude greater than SO at low loadings and temperatures, and its decreases monotonically with loading. The of SO exhibit two diffusion patterns, indicating the specific interaction between the gas molecules and the MIL-47(V) lattice.

Potential role of a novel biphenanthrene derivative isolated from in central nervous system diseases.

Central nervous system (CNS) diseases are a significant health burden globally, with the development of novel drugs lagging behind clinical needs. Orchidaceae plants have been traditionally used to treat CNS diseases, leading to the identification of therapeutic leads against CNS diseases from the orchid plant in the present study. The study isolated and characterized ten compounds, including a previously undescribed biphenanthrene derivative, Aerifalcatin (1), for the first time from the extract.

Heparan sulfate glycomimetics iterative assembly of "clickable" disaccharides.

Heparan sulfate (HS) glycosaminoglycans are widely expressed on the mammalian cell surfaces and extracellular matrices and play important roles in a variety of cell functions. Studies on the structure-activity relationships of HS have long been hampered by the challenges in obtaining chemically defined HS structures with unique sulfation patterns. Here, we report a new approach to HS glycomimetics based on iterative assembly of clickable disaccharide building blocks that mimic the disaccharide repeating units of native HS.