Immunoarchitectural Pattern and Its Potential Prognostic Value in Mucoepidermoid Carcinoma.

Objectives: To define tumor immunoarchitectural patterns (IPs) and characterize the immune profile in salivary gland mucoepidermoid carcinoma (MEC) toward assessing MEC prognostic significance and implications for immunotherapy.

Methods: This study analyzed 41 MEC cases, evaluating the tumor IPs and tumor-infiltrating lymphocyte (TIL) parameters by using whole-slide imaging and AI-assisted assessment. Immunohistochemistry of CD3 and CD8 markers was performed to assess key lymphocyte subpopulations.

Prevalence and Outcomes of Chronic Kidney Disease-Associated Pruritus: International Results from Peritoneal Dialysis Outcomes and Practice Patterns Study.

Key Points: CKD-associated pruritus is highly prevalent among peritoneal dialysis patients. Pruritus is associated with reduced health-related quality of life, and the composite of mortality and transfer to hemodialysis for peritoneal dialysis patients. Efforts to better identify and manage pruritus in this population are needed.

Cold-pressed extraction of perilla seed oil enriched with alpha-linolenic acid mitigates tumour progression and restores gut microbial homeostasis in the AOM/DSS mice model of colitis-associated colorectal cancer.

The present investigation explores into the influence of dietary nutrients, particularly alpha-linolenic acid (ALA), a plant-derived omega-3 fatty acid abundant in perilla seed oil (PSO), on the development of colitis-associated colorectal cancer (CRC). The study employs a mouse model to scrutinize the effects of ALA-rich PSO in the context of inflammation-driven CRC. Perilla seeds were subjected to oil extraction, and the nutritional composition of the obtained oil was analysed.

Unveiling three novel actinobacterial species ( sp. nov., sp. nov. and sp. nov.) in soil samples in Phu Pha Phet Cave, Thailand.

Three strains of actinobacteria, designated as B-S-A6, B-S-A8 and B-S-A12, were isolated from soil samples collected in the Phu Pha Phet Cave located in the Satun UNESCO Global Geopark, Satun Province, Thailand. A comprehensive polyphasic approach was used to describe these strains. Strains B-S-A6, B-S-A8 and B-S-A12 were identified within the genus based on a comparative examination of 16S rRNA gene sequences.

Impact of the COVID-19 outbreak on the field of hematopoietic cell transplantation in the Asia-Pacific region: APBMT Activity Survey 2020/2021.

COVID-19 became a global pandemic in 2020 and significantly affected the activity of hematopoietic cell transplants (HCT) worldwide. Despite these challenges, a total of 28,793 transplants, including 18,518 allogeneic and 10,275 autologous transplants, were performed in 719 facilities in 2020 in the Asia-Pacific (AP) region. This represented a 5.

Measurement of the electric potential and the magnetic field in the shifted analysing plane of the KATRIN experiment.

The projected sensitivity of the effective electron neutrino-mass measurement with the KATRIN experiment is below 0.3 eV (90 % CL) after 5 years of data acquisition. The sensitivity is affected by the increased rate of the background electrons from KATRIN's main spectrometer.

Preventive and therapeutic effects of genistein and daidzein on anxiety-like behaviors in ovariectomized rats.

Estrogen has demonstrated beneficial effects; however, it can also have unfavorable effects. Phytoestrogens are present in many consumable products and commonly used as supplements. These are of interest as they may have beneficial effects on mood with fewer undesirable effects on reproductive tissues.

Per- and polyfluoroalkyl substances in paired serum and breastmilk samples among pregnant farmworkers in Thailand.

Per- and polyfluoroalkyl substances (PFAS) are widely detected in pregnant persons and can be transferred to the developing fetus in utero. Breastfeeding may represent an important source of PFAS exposure for infants. However, studies quantifying levels of PFAS in breastmilk samples remain scarce, particularly in low- and middle-income countries.

Effects of a smartphone game to facilitate active neck movements on the incidence of neck pain among office workers: A 6-month cluster-randomized controlled trial.

Objectives: To evaluate the effects of a smartphone game for active neck movement exercise on perceived neck discomfort, new onset neck pain, and active cervical range of motion among high-risk office workers.

Methods: A 6-month prospective cluster-randomized controlled trial was conducted. Workers were randomly assigned at the cluster level into either the intervention group (n = 50), who received a smartphone game to play twice a day, or the control group (n = 50), who received a placebo seat pad to use while sitting.

First record of Hornylia nalanda from India (Hemiptera: Heteroptera: Reduviidae: Emesinae).

The emesine bug, Hornylia nalanda Wygodzinsky, 1966, previously described from Sri Lanka on single male specimen, has been recorded in the present study from India, based on one female specimen collected from Malappuram, Kerala. Illustrated description of the first female specimen, along with images of the holotype and comments on related species and genera within the tribe Emesini are provided.

First record of the genus Chorinaeus Holmgren, 1858 (Hymenoptera: Ichneumonidae) from India and Thailand with the description of two new species.

The metopiine genus, Chorinaeus Holmgren is reported for the first time from India and Thailand. We describe and illustrate two new species, C. amrithae Ranjith & Butcher (from India and Thailand) and C.

First record of the adeliine genus Paradelius de Saeger, 1942 (Hymenoptera: Braconidae) from India with the description of two new species.

The chelonine tribe Adeliini is one of the least studied groups in the family Braconidae. Here we report the distribution range of the genus Paradelius from the Indian subcontinent for the first time. We descibe two new species, P.

Deep Learning Architecture to Infer Kennedy Classification of Partially Edentulous Arches Using Object Detection Techniques and Piecewise Annotations.

Objectives: Dental health is integral to overall well-being, with early detection of issues critical for prevention. This research work focuses on utilizing artificial intelligence and deep learning-based object detection techniques for automated detection of common dental issues in orthopantomography x-ray images, including broken roots, periodontally compromised teeth, and the Kennedy classification of partially edentulous arches.

Methods: An orthopantomography dataset has been used to train several models employing various object detection architectures, hyperparameters, and training techniques.

Fracture resistance, 3-dimensional finite element analysis, and safety factors for five post-and-core restorations with crowns placed in the noncircular-shaped canals of premolars.

Statement Of Problem: Restoring endodontically treated premolars with noncircular canals presents a significant challenge.

Purpose: The purpose of this study was to compare the in vitro fracture resistance and the finite element computational calculation-based stress and safety factor of noncircular-shaped, endodontically treated premolars restored with 5 different prefabricated and custom computer-aided design and computer-aided manufactured post-and-core systems.

Material And Methods: Fifty single-rooted oval-shaped canal maxillary premolars were endodontically treated and post spaces were prepared.

Effect of chairside polishing systems on the surface roughness of different CAD-CAM denture base materials.

Statement Of Problem: Adjusting and polishing a denture base affects surface roughness and, consequently, microbial adhesion. Since various computer-aided design and computer-aided manufacturing (CAD-CAM) denture base materials are available, the efficiency of chairside polishing systems to achieve a proper surface roughness should be investigated.

Purpose: The purpose of this in vitro study was to compare the surface roughness of milled and 3-dimensional (3D) printed denture base materials with that of heat-polymerized acrylic resin after the use of 2 different chairside polishing systems.

Closed-loop systems for deep brain stimulation to treat neuropsychiatric disorders.

Introduction: A closed-loop or feedback-control system is a process which considers the system's output in order to automatically adjust the input. Compared to a traditional open-loop system, a closed-loop system allows for a higher degree of accuracy with minimal human intervention. Novel methods of closed loop 'adaptive' deep brain stimulation DBS (aDBS) are being developed.

Theoretical investigation of structure and electronic properties in Cisplatin-citrate complexes.

Cisplatin (CDDP) is an effective Platinum (Pt) based anticancer drug used in chemotherapy. However, its effectiveness is limited due to its instability in solvents, along with the side effects it causes due to DNA damage. Nanoparticles (NPs) were developed in vitro to address these issues by loading CDDP into various types of NPs, including metal, lipid, and biological NPs.

Truncated recombinant Jagged1 fused with human IgG1 Fc activates Notch target genes in human periodontal ligament cells.

Objective: Jagged1, a Notch ligand, is essential for osteogenic differentiation in human periodontal ligament cells (hPDLs) by interacting with Notch2 to induce osteogenic markers, alkaline phosphatase activity, and mineral deposition. However, its large size hampers absorption and distribution of biomaterials. This study aimed to identify the critical region of Jagged1 necessary for its interaction with Notch2 to create a truncated version that retains osteogenic activity but with improved delivery characteristics.