21,244 results match your criteria: "Chulalongkorn University; chenphop@gmail.com.[Affiliation]"

Effects of Different Self-Adhesive Resin Cements and Curing Through Zirconia on Gingival Fibroblasts.

Int Dent J

December 2024

Center of Excellence in Genomics and Precision Dentistry, Clinical Research Center, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; Geriatric Dentistry and Special Patients Care International Program, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Electronic address:

Introduction: Self-adhesive resin cements (SARCs) are widely used for fixed prostheses. These cements and their eluted products may affect periodontal tissues. This study aimed to investigate the response of human gingival fibroblasts (HGFs) to eluates from SARCs in vitro, simulating clinical conditions after prosthesis fixation, to gain insights into their potential effects on gingival health.

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Objective: This study aimed to evaluate the effects of a therapeutic lifestyle modification (TLM) intervention on health-related quality of life, sexual functioning and cardiometabolic health in perimenopausal Chinese women.

Method: The study was a randomized controlled trial (registration number: ChiCTR2300070648). Ninety-four perimenopausal women aged between 40 and 55 years were randomly assigned in a 1:1 ratio to receive the TLM intervention or usual care for 12 weeks.

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Longitudinal Associations Between Psychological Resilience and Cognitive Function:Evidence from the U.S. Health and Retirement Study.

J Gerontol B Psychol Sci Soc Sci

December 2024

Department of Family Medicine and Community Health, Duke University School of Medicine, Duke University School of Nursing, Durham, North Carolina, USA.

Objective: Reductions in psychological resilience and declining cognition are common among older adults. Understanding the longitudinal association between them could be beneficial for interventions that focus on age-related cognitive and psychological health. In this study, we evaluated the longitudinal associations between cognition and psychological resilience over time in a nationally representative sample of US older adults.

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Exploring dietary methods to alter microbial communities and metabolic functions is becoming an increasingly fascinating strategy for improving health. Copra meal hydrolysate (CMH) is alternatively used as a gut health supplement. However, the functional diversity and metabolic activities in gut microbiome in relation to CMH treatment remain largely unknown.

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Impact of drying techniques on volatile aroma profiles and formation mechanisms of black soybean thua nao.

Food Chem X

December 2024

Department of Food Technology, Faculty of Science, Chulalongkorn University, Phayatai Road, Wangmai, Pathumwan, Bangkok 10330, Thailand.

Thua nao, a traditional Thai fermented soybean, offers a unique aroma and nutritional value. However, fresh thua nao cannot be stored for long periods due to its high in water activity (a). This study examined the effects of various drying methods, including natural sun drying and machine drying methods, namely hot air, microwave vacuum (MIC), and vacuum drying on the qualities of dried black soybean thua nao.

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Objective: The study aims to analyze the interconnectedness of farmers' socioeconomic factors and their awareness of the One Health framework.

Method: This study conducted a survey with 1,166 observations across Thailand, Lao, and Vietnam and employed binary logit regression for data analysis. Odds ratios were used for interpreting the results.

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Background: Hyperphosphatemia poses a significant risk for cardiovascular diseases and mortality in hemodialysis patients. Non-adherence to phosphate binders and a low-phosphate diet behavior contribute to this issue. Leveraging psychological and behavior change theories has proven effective in addressing many health risks.

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Article Synopsis
  • * Researchers analyzed data from 450 patients, finding that 310 were classified as ultra-low risk (ULR) based on their rapid clinical response and low MAP scores, leading to significantly better outcomes.
  • * Patients in the ULR group had higher response rates at day 28 and lower non-relapse mortality at six months, suggesting that careful monitoring can guide safer, more effective GVHD treatment strategies.
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Objective: Although aging well and aging in place policies have been encouraged in many countries, a consistent challenge is insufficient evidence on older migrants. This study compared mental well-being models of older adults between aging in place and aging migrant groups. The model included social factors (e.

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Violence against women and its effects on mental health and quality of life: A study of Myanmar migrant workers in Central Thailand.

J Migr Health

October 2024

College of Public Health Sciences, Chulalongkorn University, 12th floor, Sabbasastravicaya Building, Soi Chulalongkorn 62, Phayathai Road, Pathumwan, Bangkok, 10300, Thailand.

Background: Women migrant workers are vulnerable to violence. Violence against women is a pervasive public health problem, violates women's rights, and may adversely affect women's quality of life (QoL) and mental health. However, few studies have focused on this problem among migrant women workers from Myanmar.

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Mechanical forces control a multitude of biological responses in various cells and tissues. The periodontal ligament, located between the tooth's root and alveolar bone, is a major tissue compartment that is incessantly subjected to such mechanical stimulation through either normal or abnormal oral functionality. It is now known that mechanical stimulation activates periodontal ligament stem cells (PDLSCs) to modulate periodontal immunity and regulate inflammation - a basic feature of periodontal disease that affects virtually every human during their lifetime.

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Gastrointestinal: Direct Visualization of Biliary Tuberculosis.

J Gastroenterol Hepatol

December 2024

Gastrointestinal Endoscopy Excellence Center, Division of Gastroenterology, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Background: Biliary tuberculosis is a rare type of hepatobiliary tuberculosis. Clinical presentation, imaging, or cholangiogram are difficult to distinguish from other common causes of cholangiopathy or malignancy. Direct visualization of bile duct via cholangioscopy and targeted biopsy was introduced as one of effective investigations for tissue acquisition and diagnosis.

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Objectives: Validation and performance assessment of novel ESR analyzer is required before implementation. The objective of this study was to assess the correlation between three ESR measurement methods. Full validation and performance assessment of an alternate method (TEST1) were also evaluated.

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Background: Delivery mode can influence infant microbial diversity, cause immune dysregulation, and potentially increase the risk of allergic rhinitis (AR).

Methodology: A systematic review and meta-analysis were performed to assess the association between distinct modes of delivery and the development of AR in childhood and adulthood. The primary comparison was vaginal (VD) versus cesarean delivery (CD).

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Article Synopsis
  • The study addresses intervertebral disc degeneration (IDD), a leading cause of chronic back pain, and aims to create a convolutional neural network (CNN) based on MRI scans for precise grading using the Pfirrmann system.
  • The model was trained on a dataset of MRI studies, and its performance was rigorously evaluated across various metrics, showing impressive results in classifying different grades of IDD.
  • The findings suggest that the AI model is highly accurate and reliable for detecting and grading lumbar IDD, potentially improving treatment outcomes for patients suffering from back pain.
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Superconductivity in hexagonal CeLaH under high pressure.

Phys Chem Chem Phys

January 2025

Extreme Conditions Physics Research Laboratory and Center of Excellence in Physics of Energy Materials (CE:PEM), Department of Physics, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Recently, experimental observation has shown that the substitutional alloy (Ce,La)H can be successfully synthesized under high pressure, approximately 90-170 GPa, and become a superconductor with a high critical temperature () superconductivity in ternary rare-earth clathrate hydrides between 148-178 K. In this work, we theoretically simplified the hydride alloy (Ce,La)H, a compound in a series that could function as a potential superconductor, with CeLaH exhibiting strong electron-phonon coupling (EPC). The CeLaH alloy is scrutinized for its lattice dynamical stability in the pressure range of 100 to 150 GPa.

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Background: Percutaneous coronary intervention (PCI) outcomes can vary due to various factors, including patient clinical condition, complexity of coronary lesions, expertise of operators, and quality of the PCI center.

Aims: This study evaluated the influence of PCI center volume and operator experience on patient outcomes after the procedure.

Methods: Retrospective data on demographic, clinical details, and outcomes for all patients undergoing PCI across 39 hospitals in Thailand from 2018 to 2019 were retrieved.

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The Role of Soft Skills in Dental Education: Challenges and Importance.

Eur J Dent

December 2024

Centre of Excellence for Regenerative Dentistry, Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Soft skills encompass interpersonal abilities and values that enable individuals to adapt to diverse circumstances. In dentistry, a combination of soft and hard skills is crucial for successful practice and for achieving health care organization goals. However, dental schools face significant challenges in teaching and evaluating soft skills, including the subjective nature of assessment, variability in student engagement, and the lack of standardized curricula.

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Background: Cervical cancer remains a significant global health concern, ranking as the fourth most prevalent cancer among women worldwide. Human papillomaviruses (HPV) transcribe many genes that might be responsible for cervical cancer development. This study aims to investigate the correlation between the expression of HPV16 early genes and the mRNA expression of human FOXO3a, a tumor suppressor gene, in association with various stages of cervical precancerous lesions.

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Introduction: Carbapenem-resistant Enterobacterales (CRE), particularly carbapenemase-producing , pose a significant global health challenge due to their resistance to last-resort antibiotics. This study investigates the genetic characteristics and clonal relationships of CRE isolated from canine and human clinical samples in Bangkok to understand potential interspecies transmission.

Methods: Fifty-two CRE isolates were collected from 477 clinical samples from dogs and humans at Chulalongkorn University between 2017-2021.

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Molecular profiles and long-term outcomes of Thai children with hepatic glycogen storage disease in Thailand.

World J Clin Pediatr

December 2024

Center of Excellence for Medical Genetics, Department of Pediatrics, King Chulalongkorn Mem Hosp, Dept Pediat, Div Med Genet and Metab, Sor Kor Bldg, Chulalongkorn University, Bangkok 10330, Thailand.

Article Synopsis
  • Genetic analysis of eight Thai children diagnosed with hepatic glycogen storage diseases (GSD) revealed various subtypes through whole-exome sequencing, with common symptoms including hepatomegaly and hypoglycemia.
  • Treatments primarily involved cornstarch supplementation and dietary adjustments, leading to improved health outcomes over a median follow-up of nearly 10 years.
  • The study emphasizes the importance of molecular analysis for accurate diagnosis and tailored treatment plans for better long-term management of GSD in affected patients.
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Bupropion is used as smoking cessation drug and antidepressant. Drug overdose has multi-system involvement including neurotoxicity and cardiovascular collapse. Use of haemoperfusion in bupropion toxicity is generally not useful, however in life-threatening condition it could be a life saver.

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Background: Several studies have proved that diacerein effectively treats knee osteoarthritis (OA). All studies used branded diacerein. Recently, generic diacerein has been available in several countries, with limited studies comparing the efficacy of generic and branded diacerein for knee OA treatment.

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Diagnostic performance of FibroTouch® in assessing hepatic steatosis and fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: An Asian experience.

Ann Hepatol

December 2024

Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address:

Introduction And Objectives: FibroTouch® has shown efficacy in staging hepatic fibrosis in patients with chronic viral hepatitis B, but its performance in assessing liver steatosis and fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD) patients remains understudied. We aimed to evaluate the diagnostic performance of FibroTouch® in assessing steatosis and fibrosis in the MASLD population.

Materials And Methods: Liver stiffness measurements and steatosis were assessed using FibroTouch® and FibroScan®, with FibroScan® as the reference standard.

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