Investigation of the physical, chemical, and biological properties of the cockle shell-derived calcium silicate-based pulp capping material: a pilot study.

Introduction: Hard-setting calcium hydroxide-based materials, e.g., Dycal and Life, have been widely used for direct pulp capping.

The new gamma interferon (IFN-γ) algorithm for tuberculosis diagnosis in cynomolgus macaques.

Tuberculosis (TB) is the first infectious disease to be screened-out from specified pathogen-free cynomolgus macaques (Macaca fascicularis; Mf) using in human pharmaceutical testing. Being in either latent or active stage after exposure to the Mycobacterium tuberculosis complex (MTBC), the monkey gamma-interferon release assay (mIGRA) was previously introduced for early TB detection. However, a notable incidence of indeterminate results was observed.

Fluctuation of tissue eosinophils in chronic rhinosinusitis with nasal polyp.

Introduction: Tissue eosinophil count (TEC) is recommended for defining Type 2 chronic rhinosinusitis with nasal polyps (CRSwNP). TEC is usually assessed by a one-time polyp biopsy. Because TEC may change over time, its reliability for diagnosing type 2 CRSwNP has not been previously assessed.

Confirmatory Cytopathology and Potential Impact on the Predictive Value of Gene Expression Profiling in Patients With Uveal Melanoma.

To determine whether the availability of a cytopathology-confirming diagnosis is correlated with the prognostic accuracy of a gene expression profiling assay. A single-center retrospective review was performed of patients diagnosed with uveal melanoma who had a fine-needle aspiration biopsy and gene expression profiling before proton therapy from 2012 to 2020. The development of metastases was compared in patients with gene expression profiling and cytopathology (gene expression profiling+cytopathology group) and patients with gene expression profiling only (gene expression profiling only group).

Cardiovascular risk improvement after laparoscopic adrenalectomy in patients with cortisol-secreting adrenal adenoma, a retrospective cohort study.

Background: Cushing syndrome increases morbidity and mortality, which is mainly caused by cardiovascular disorders. This study reports the cardiovascular risk outcomes at 3, 6, and 12 months after unilateral laparoscopic adrenalectomy in cortisol-secreting adrenal tumor and to identify the preoperative parameters predicting the resolution of cardiovascular risk factors after surgery.

Methods: All clinical data of patients with unilateral cortisol-secreting adrenal tumors who underwent laparoscopic adrenalectomy in King Chulalongkorn Memorial Hospital between 2001-2022 were retrospectively reviewed.

The effects of alpha-lipoic acid transdermal patch for local subcutaneous fat reduction: A randomized, placebo-controlled, clinical trial in overweight volunteers.

Background: Combating obesity is challenging, as anti-obesity compounds lose effectiveness or cause severe side effects when delivered via conventional routes. Thus, there is a need for new, effective treatment routes that are home-based and safe for long-term use. This double-blind, placebo-controlled clinical trial aimed to investigate the efficacy of a biocellulose transdermal patch containing α-lipoic acid (ALA), an anti-obesity compound, in reducing subcutaneous fat accumulation.

OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation.

Protein asparagine (N)-glycosylation, which promotes folding and trafficking of cell surface receptors such as the EGFR, has not been considered a viable target in oncology due to the essential and non-redundant enzymatic activities required for glycan synthesis and transfer. In mammals an exception to this rule is the presence of the oligosaccharyltransferase (OST) catalytic subunit paralogs, STT3A and STT3B. Here we delineate the chemical biology of OST inhibitors and develop an approach for limited inhibition of N-glycosylation optimized for downstream effects on EGFR.

Neonatal survival rate after expectant management of periviable preterm premature rupture of membranes at gestational age 15-23 weeks.

Objective: To assess the neonatal survival rates, maternal complications, neonatal complications, and factors associated with survival rates following periviable premature rupture of membranes (PROM) between 15 and 23 weeks of gestation.

Materials And Methods: The retrospective study included patients with periviable PROM between 15 and 23 weeks of gestation from January 1, 2008, to December 31, 2022. Multivariate regression analysis was performed to identify factors influencing neonatal survival.

Prenatal exposure to pesticide mixtures and the placental transcriptome: Insights from trimester-specific, sex-specific and metabolite-scaled analyses in the SAWASDEE cohort.

We investigated the effect of exposure to pesticide mixtures during pregnancy on the placental transcriptome, to link these exposures and placental functions. The Study of Asian Women and their Offspring's Development and Environmental Exposures (SAWASDEE) enrolled pregnant farmworkers from Thailand (n = 248), who were primarily exposed to organophosphate (OP) and pyrethroid pesticides. We measured maternal urinary levels of six non-specific OP metabolites expressed as three summary measures (dimethylalkylphosphates (DMAP), diethylalkylphosphates (DEAP), and dialkylphosphates (DAP) and three pyrethroid metabolites (3-phenoxybenzoic acid (3-PBA), cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis-DCCA, trans-DCCA) during early, middle, and late pregnancy, and adjusted for urine dilution using creatinine.

Highly sensitive and real-time detection of acetone biomarker for diabetes using a ZnO-coated optical fiber sensor.

This work presents a ZnO-coated no-core optical fiber sensor (OFS) designed for the highly sensitive detection of acetone vapor. Acetone is a key biomarker for diabetes, which is linked to blood glucose levels and can be detected non-invasively through breath analysis. The OFS utilizes a no-core fiber (NCF) as the sensing region, coated with a thin layer of ZnO nanoparticles to enhance evanescent field interaction with the VOCs at the fiber interface.

Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup.

Diet significantly influences the human gut microbiota, a key player in health. We analyzed shotgun metagenomic sequencing data from healthy individuals with long-term dietary patterns-vegan, flexitarian, or omnivore-and included detailed dietary surveys and blood biomarkers. Dietary patterns notably affected the bacterial community composition by altering the relative abundances of certain species but had a minimal impact on microbial functional repertoires.

Effects of Different Self-Adhesive Resin Cements and Curing Through Zirconia on Gingival Fibroblasts.

Introduction: Self-adhesive resin cements (SARCs) are widely used for fixed prostheses. These cements and their eluted products may affect periodontal tissues. This study aimed to investigate the response of human gingival fibroblasts (HGFs) to eluates from SARCs in vitro, simulating clinical conditions after prosthesis fixation, to gain insights into their potential effects on gingival health.

Effects of a therapeutic lifestyle modification intervention on health-related quality of life and sexual functioning and cardiometabolic health in perimenopausal Chinese women: a randomized controlled trial.

Objective: This study aimed to evaluate the effects of a therapeutic lifestyle modification (TLM) intervention on health-related quality of life, sexual functioning and cardiometabolic health in perimenopausal Chinese women.

Method: The study was a randomized controlled trial (registration number: ChiCTR2300070648). Ninety-four perimenopausal women aged between 40 and 55 years were randomly assigned in a 1:1 ratio to receive the TLM intervention or usual care for 12 weeks.

Longitudinal Associations Between Psychological Resilience and Cognitive Function:Evidence from the U.S. Health and Retirement Study.

Objective: Reductions in psychological resilience and declining cognition are common among older adults. Understanding the longitudinal association between them could be beneficial for interventions that focus on age-related cognitive and psychological health. In this study, we evaluated the longitudinal associations between cognition and psychological resilience over time in a nationally representative sample of US older adults.

Exploring the functional diversity and metabolic activities of the human gut microbiome in Thai adults in response to a prebiotic diet.

Exploring dietary methods to alter microbial communities and metabolic functions is becoming an increasingly fascinating strategy for improving health. Copra meal hydrolysate (CMH) is alternatively used as a gut health supplement. However, the functional diversity and metabolic activities in gut microbiome in relation to CMH treatment remain largely unknown.

Impact of drying techniques on volatile aroma profiles and formation mechanisms of black soybean thua nao.

Thua nao, a traditional Thai fermented soybean, offers a unique aroma and nutritional value. However, fresh thua nao cannot be stored for long periods due to its high in water activity (a). This study examined the effects of various drying methods, including natural sun drying and machine drying methods, namely hot air, microwave vacuum (MIC), and vacuum drying on the qualities of dried black soybean thua nao.

One Health in Agricultural Sectors in Thailand, Lao PDR, and Vietnam: Interconnectedness Between Awareness and Socioeconomic Factors.

Objective: The study aims to analyze the interconnectedness of farmers' socioeconomic factors and their awareness of the One Health framework.

Method: This study conducted a survey with 1,166 observations across Thailand, Lao, and Vietnam and employed binary logit regression for data analysis. Odds ratios were used for interpreting the results.

Effect of a transtheoretical model-based intervention and motivational interviewing on hyperphosphatemia management via telehealth (TMT program) among hemodialysis patients during the COVID-19 pandemic.

Background: Hyperphosphatemia poses a significant risk for cardiovascular diseases and mortality in hemodialysis patients. Non-adherence to phosphate binders and a low-phosphate diet behavior contribute to this issue. Leveraging psychological and behavior change theories has proven effective in addressing many health risks.

Mental well-being model of Thai older adults: Comparing the aging in place and aging migrant groups.

Objective: Although aging well and aging in place policies have been encouraged in many countries, a consistent challenge is insufficient evidence on older migrants. This study compared mental well-being models of older adults between aging in place and aging migrant groups. The model included social factors (e.

Violence against women and its effects on mental health and quality of life: A study of Myanmar migrant workers in Central Thailand.

Background: Women migrant workers are vulnerable to violence. Violence against women is a pervasive public health problem, violates women's rights, and may adversely affect women's quality of life (QoL) and mental health. However, few studies have focused on this problem among migrant women workers from Myanmar.

Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells.

Mechanical forces control a multitude of biological responses in various cells and tissues. The periodontal ligament, located between the tooth's root and alveolar bone, is a major tissue compartment that is incessantly subjected to such mechanical stimulation through either normal or abnormal oral functionality. It is now known that mechanical stimulation activates periodontal ligament stem cells (PDLSCs) to modulate periodontal immunity and regulate inflammation - a basic feature of periodontal disease that affects virtually every human during their lifetime.