21,192 results match your criteria: "Chulalongkorn University; and the King Chulalongkorn Memorial Hospital[Affiliation]"

Article Synopsis
  • - The World Health Organization has identified Thailand as a hotspot for leishmaniasis, with increasing cases of the disease caused by two local species leading to various clinical presentations.
  • - A new duplex TaqMan quantitative PCR assay was developed to diagnose and differentiate between the two species causing visceral and cutaneous leishmaniasis, utilizing specific primers and probes for accurate detection.
  • - The assay demonstrated excellent diagnostic performance, achieving 100% sensitivity and specificity, and proving to be a rapid and cost-effective solution for detecting these parasitic infections in clinical and environmental samples.
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An all-perovskite tandem cell based on narrow-bandgap mixed tin-lead (Sn-Pb) alloyed perovskites is a potential photovoltaic device whose power conversion efficiency can exceed the Shockley-Queisser limit of a single-junction solar cell, 33%. However, comprehensive descriptions of the charge-carrier mobilities and transport mechanisms in the mixed Sn-Pb perovskite system remain elusive. Herein, we integrate density functional theory (DFT) calculations with charge transport models to provide more insight into the electronic structures and transport behaviors of these materials.

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Objectives: This study aimed to evaluate the clinical performance of ceramic veneers after 9-10 years, assess patient-reported outcomes, and examine their associations.

Materials And Methods: Thirty patients with ceramic veneers aged 9-10 years were recalled for a clinical examination. Each participant completed a questionnaire on satisfaction and oral health-related quality of life, specifically using the Oral Impact on Daily Performance (OIDP) scale.

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Chemical profiling and clustering of various dried cannabis flowers revealed by volatilomics and chemometric processing.

J Cannabis Res

December 2024

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

Cannabis flower scent is one of the key characteristics of the cannabis plant. The diverse scents impact user experiences and offer medicinal benefits. These scents originate from volatile compounds, particularly terpenes and terpenoids.

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Furopyridine Derivatives as Potent Inhibitors of the Wild Type, L858R/T790M, and L858R/T790M/C797S EGFR.

J Phys Chem B

December 2024

Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

The treatment of patients with nonsmall cell lung cancer (NSCLC) using epidermal growth factor receptor (EGFR) inhibitors is complicated by drug-sensitive activating L858R/T790M and L858R/T790M/C797S mutations. To overcome drug resistance, a series of furopyridine (PD) compounds were virtually screened to identify potent EGFR inhibitors using molecular docking and molecular dynamics (MD) simulations based on the solvated interaction energy (SIE) method. Several PD compounds identified from virtual screening demonstrated the potential to suppress both wild-type and mutant forms of EGFR, with IC values in the nanomolar range.

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Objectives: Global concern is increasing about the health effects of electronic waste (e-waste). This study examines the health impacts of heavy metal (HM) exposure among e-waste workers (EWWs) and community-dwelling adults (CDAs) in Northeastern Thailand and identifies factors associated with adverse health outcomes.

Methods: A cross-sectional study was conducted of 164 EWWs and 164 CDAs.

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Calcium chloride supplementation in sows: Enhancing farrowing efficiency and piglet viability during transition period.

Theriogenology

March 2025

Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Swine Reproduction, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:

High-prolific sows have a high incidence of stillbirth and asphyxiated piglets due to calcium deficiencies. Calcium is important for enhancing farrowing efficacy and colostrum production. Calcium chloride (CaCl), an acidogenic compound that lowers dietary cation-anion difference (DCAD), promotes calcium mobilization, thereby mitigating the risk of calcium deficiency.

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The gut mycobiota (fungal microbiota) plays a crucial role in the immune system, potentially impacting autoimmune diseases such as systemic lupus erythematosus (SLE). Despite growing interest, data on intestinal fungi in SLE remain limited. This study thereby investigated the human-mimicked (mice) gut mycobiome and quantitative gut mycobiome analyses using universal fungal internal transcribed spacer 2 (ITS2) DNA next generation sequencing and real-time PCR, tracking time-series dynamics from preclinical to established SLE conditions in two SLE-prone mouse models.

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ProCAPTCHA: A profile-based CAPTCHA for personal password authentication.

PLoS One

December 2024

Department of Mathematics and Computer Science, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.

CAPTCHA was introduced decades ago to distinguish between humans and bots. However, solving CAPTCHA has been a challenging issue for intruders. Various techniques, such as 3rd-party attacks, have been invented to break CAPTCHA.

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Evolving therapies for atopic dermatitis: Bridging guidelines and practice.

Ann Acad Med Singap

November 2024

Division of Dermatology, Department of Medicine, Faculty of Medicine, Center of Excellence for Skin and Allergy Research, Chulalongkorn University, Thailand.

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Article Synopsis
  • The study investigated knowledge, attitudes, and practices (KAP) regarding swine influenza virus (SIV) among pig farm owners, workers, and villagers in Thailand from February to December 2022, using a structured questionnaire with 215 participants.
  • Results showed moderate knowledge (6.92/12) and positive attitudes (3.74/5) towards SIV, with factors like higher education, income, and involvement in vaccination processes linked to better KAP scores.
  • The study recommends that local health authorities focus on creating tailored educational strategies for pig farming communities and nearby villagers to enhance awareness and practices regarding SIV and related diseases.
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Development and validation of a deep learning algorithm for the classification of the level of surgical difficulty in impacted mandibular third molar surgery.

Int J Oral Maxillofac Surg

December 2024

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; Oral and Maxillofacial Surgery and Digital Implant Surgery Research Unit, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Article Synopsis
  • This study developed and validated a convolutional neural network (CNN) called YOLOv5 to identify impacted mandibular third molars in panoramic radiographs and classify the difficulty of their extraction.* -
  • The algorithm was trained on 1,300 images and tested on 430 images, showing a solid performance with precision-recall curves ranging from 72% to 89% and an AUC of 87% for classifying surgical difficulty levels.* -
  • The YOLOv5 model demonstrated a strong agreement with human experts, suggesting it could enhance clinical decision-making and be useful in screening for third molar issues.*
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Andrographolide attenuates SARS-CoV-2 infection via an up-regulation of glutamate-cysteine ligase catalytic subunit (GCLC).

Phytomedicine

November 2024

Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand; Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok 10400, Thailand. Electronic address:

Article Synopsis
  • Andrographolide, a medicinal compound, shows potential anti-SARS-CoV-2 activity by targeting cellular pathways, particularly involving the NRF2 transcription factor in lung epithelial cells.
  • The study used various methods like immunofluorescence staining and proteomic analysis to investigate the effects of andrographolide on infected lung cells, focusing on gene expression and cellular glutathione levels.
  • Results revealed that andrographolide enhances NRF2 expression and promotes glutathione production, which could help counteract SARS-CoV-2 infection effects in lung cells.
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Article Synopsis
  • Tracheobronchitis (AT) is a rare but severe form of invasive pulmonary aspergillosis that occurs infrequently in HIV-infected individuals, making up only 4.5% of cases according to recent studies.
  • The use of modern antiretroviral therapy (ART) has decreased the incidence of opportunistic infections like AT in well-managed HIV patients.
  • A case study of a young woman with controlled HIV who developed AT despite her treatment highlights the importance of recognizing respiratory symptoms, as swift diagnosis and antifungal treatment are crucial for better patient outcomes.*
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Clinical neurophysiology for tremor: Common questions in clinical practice.

Parkinsonism Relat Disord

January 2025

Clinica Alemana, Universidad del Desarrollo, Santiago, Chile; Instituto Nacional de Movimientos Anormales, Santiago, Chile. Electronic address:

Article Synopsis
  • A detailed physical exam might not fully reveal the complexities of tremors; neurophysiology can help clarify these conditions.
  • The study involved a panel of experts who investigated how neurophysiological techniques can enhance understanding of various movement disorders, especially different types of tremors.
  • The findings emphasize the importance of neurophysiological assessments in accurately identifying and distinguishing between diverse tremor syndromes and other similar movement disorders.
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The impact of RUNX2 gene variants on cleidocranial dysplasia phenotype: a systematic review.

J Transl Med

December 2024

Department of Physiology, Center of Excellence in Genomics and Precision Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.

Cleidocranial Dysplasia (CCD) is a rare genetic disorder characterized by skeletal abnormalities and dental anomalies, primarily caused by variants in the RUNX2 gene. Understanding the spectrum of RUNX2 variants and their effects on CCD phenotypes is crucial for accurate diagnosis and management strategies. This systematic review aimed to comprehensively analyze the genotypic and phenotypic spectra of RUNX2 variants in CCD patients, assess their distribution across functional regions, and investigate genotype-phenotype correlations.

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Article Synopsis
  • * A study examined HIF-1α levels in the bone marrow of 29 newly diagnosed NPM1FLT3-ITD normal karyotype AML patients and found that over half exhibited strong HIF-1α expression, correlating this with increased relapse rates and shorter relapse-free survival (RFS).
  • * High HIF-1α levels might serve as a useful prognostic biomarker for predicting poor RFS and resistance to cytarabine in NPM1FLT
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Article Synopsis
  • The study focuses on detecting multijet signatures from proton-proton collisions at a high energy of 13 TeV, analyzing a dataset totaling 128 fb^{-1}.
  • A special data scouting method is utilized to pick out events with low combined momentum in jets.
  • This research is pioneering in its investigation of electroweak particle production in R-parity violating supersymmetric models, particularly examining hadronically decaying mass-degenerate higgsinos, and it broadens the limits on the existence of R-parity violating top squarks and gluinos.
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Article Synopsis
  • * Over a 35-day period, these microbiomes achieved a remarkable 99% reduction of DEHP, with specific bacterial groups identified as key contributors to the degradation process.
  • * In addition, certain bacterial strains, like Gordonia sp. and Gordonia polyisoprenivorans, were found to degrade DEHP by 65-97% within just 7 days, showing potential for broader application in addressing plastic pollution.
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Asian adult sleep medicine fellowship training curriculum: one curriculum, many contexts.

J Clin Sleep Med

December 2024

Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan; Department of Somnology, Tokyo Medical University, Tokyo, Japan.

Article Synopsis
  • The study aims to create a flexible yet standardized sleep medicine fellowship curriculum tailored for diverse healthcare settings across Asia, addressing existing training disparities.
  • The development process included a thorough gap analysis, literature review, and expert consensus through a structured survey method.
  • The resulting curriculum features two training tracks (one-year and two-year), detailed learning outcomes, competency-based content, and comprehensive assessment strategies to enhance sleep medicine education and patient care in the region.
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Unveiling the Diversity of the Semislug Genus Blanford, 1863 (Eupulmonata: Helicarionidae) from Thailand and Myanmar, with Description of Two New Species.

Zool Stud

June 2024

Animal Systematics Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand. E-mail: (Pholyotha); (Sutcharit).

Article Synopsis
  • The terrestrial semislug genus, which belongs to the Helicarionidae family, includes nine species found in Thailand and Myanmar, with two species based solely on shell characteristics.
  • The taxonomy of these species is discussed using comparative morphology, leading to revised descriptions for four existing species, and the reclassification of another species into this genus.
  • Two new species, Pholyotha & Panha, sp. nov., are introduced, and unique shell and genital features are highlighted as distinguishing factors, with only one species lacking a dart apparatus.
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Article Synopsis
  • A series of bimetallic Cu-Ni phyllosilicates (Cu-NiPS) with different nickel to copper ratios were synthesized using an ammonia evaporation hydrothermal method for hydrogenation reactions.
  • These catalysts effectively converted furfural (FF) to furfuryl alcohol (FA) under mild conditions, with the copper-rich variant showing the best performance (88% conversion and 90% selectivity).
  • The superior catalytic activity of the copper-rich alloy is linked to its smaller particle size, higher copper content, and the beneficial interactions between nickel and copper that enhance hydrogen dissociation and stabilization of the carbonyl group.
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Genetic Diversity and Population Dynamics of spp. Using Comprehensive Bioinformatics Approaches.

Vet Med Int

November 2024

Parasitology Unit, Department of Pathology and Biomarkers in Animal Parasitology Research Unit, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.

Article Synopsis
  • The study investigates the genetic diversity and population structure of a parasitic pathogen affecting freshwater fish, which has been previously under-researched globally.
  • By analyzing specific genetic markers (18S rDNA and ITS genes), the researchers identified 12 distinct haplotypes and found significant genetic variation patterns among populations across different continents.
  • Results indicate an expansion of populations in countries like India, America, and Kenya, highlighting the need for improved management strategies to control this parasite in aquaculture.
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Article Synopsis
  • * Fourteen patients who struggled with traditional oral medications received fluoroscopy-guided injections, resulting in significant reductions in both pain scores and frequency of pain attacks after 60 days.
  • * Complications included temporary side effects like hemifacial palsy and diplopia, which resolved within three months, suggesting the treatment is relatively safe.
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