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Mycosporine-like amino acids stimulate hyaluronan secretion by up-regulating hyaluronan synthase 2 via activation of the p38/MSK1/CREB/c-Fos/AP-1 axis.
J Biol Chem
May 2020
Center for Bioscience Research and Education, Utsunomiya University, Tochigi 321-8505, Japan; Research Institute for Biological Functions, Chubu University of Technology, Aichi 487-8501, Japan. Electronic address:
Article Synopsis
- Hyaluronan (HA) is important for skin health and is secreted by fibroblasts.
- Mycosporine-like amino acids (MAAs) boost HA secretion by affecting gene expression related to HA synthesis and breakdown.
- The signaling pathway involved in this process includes p38 MAPK, MSK1, and transcription factors like CREB and c-Fos, which increase mRNA levels of HA synthase 2 (HAS2).