1,343 results match your criteria: "Chromoblastomycosis"

Dematiaceous Molds.

Infect Dis Clin North Am

December 2024

Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Belfer 610, Bronx, NY 10461, USA. Electronic address:

Dematiaceous molds are darkly pigmented environmental molds found worldwide, especially prevalent in tropical and subtropical regions. Common genera include Bipolaris, Cladophialophora, Exophiala, and Alternaria. They cause disease in both immunocompetent and immunocompromised individuals, presenting as cutaneous infections, allergic sinusitis, pneumonia, and, rarely, disseminated infections.

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Introduction: Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses.

Aims And Objectives: To observe various morphological presentations and histopathological features of deep fungal infections.

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Chromoblastomycosis is an uncommon, chronic granulomatous fungal infection of the skin and subcutaneous tissue. Chromoblastomycosis is most commonly caused by the traumatic inoculation of dematiaceous (pigmented) fungi, most commonly species,  species, and species. Chromoblastomycosis usually affects agricultural workers in tropical and subtropical climates.

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This is the case of chronic chromoblastomycosis (CBM) in a 61-year-old male from the Dominican Republic (DR) with extensive cutaneous eruptions over multiple areas of the body including bilateral lower extremities and the flank extending to the back. A 61-year-old male with a history of morbid obesity, chronic kidney disease stage III, and well-controlled hypertension presented to the family medicine clinic for the evaluation of chronic painful skin lesions on his legs and torso. The lesions began 19 years prior, following a flood in the Dominican Republic (DR) where he was living at the time.

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Chromoblastomycosis in Brazil: A review of 450 published cases.

Rev Soc Bras Med Trop

November 2024

Universidade Federal da Grande Dourados, Faculdade de Ciências da Saúde, Dourados, MS, Brasil.

Chromoblastomycosis is a skin infection caused by melanized fungi that primarily affects rural workers. This study aimed to analyze the clinical and epidemiological manifestations of chromoblastomycosis in Brazil through an extensive literature review. A review of case reports or series of cases in English and Portuguese was conducted using the SciELO, LILACS, SCOPUS, PubMed, and Web of Science databases from 1963 to 2022.

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A global chromoblastomycosis strategy and development of the global chromoblastomycosis working group.

PLoS Negl Trop Dis

October 2024

Department of Infectious Diseases and Infection Control, Universidade Federal do Maranhão, Maranhão, Brazil.

Chromoblastomycosis, an implantation mycosis, is a neglected tropical disease that causes decreased quality of life, stigma, and disability. The global burden of disease is unknown and data on disease epidemiology and outcomes are severely limited by a lack of access to needed diagnostic tools and therapeutics. The World Health Organization outlined targets for chromoblastomycosis in the Road Map for Neglected Tropical Diseases 2021-2030, but little progress has been made in initiating and implementing an effective control program globally.

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[Chromoblastomycosis of the lung: report of a case].

Zhonghua Bing Li Xue Za Zhi

October 2024

Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.

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Article Synopsis
  • Chromoblastomycosis is a rare fungal infection that can appear as chronic skin lesions, especially in non-endemic areas like Lebanon.
  • Patients with these persistent, wart-like lesions that don't respond to standard treatments should be evaluated for this condition.
  • A combination of oral antifungals, cryotherapy, and topical 5-Fluorouracil has proven effective, with follow-ups showing lasting clearance of lesions and no recurrences at three and six months post-treatment.
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Article Synopsis
  • Chromoblastomycosis (CBM) is a chronic skin and tissue infection that has been documented in Pakistan, highlighting varied demographics and treatment outcomes.
  • A study analyzed 16 cases of CBM from 2016 to 2022, revealing that most patients were young males, predominantly affected in the lower extremities, and showing specific histopathological features.
  • The findings emphasize the need for increased awareness of CBM among healthcare providers in Pakistan, particularly for patients with relevant histories, and call for enhanced collaboration among clinicians and lab specialists for timely diagnosis and treatment.
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Development of PCR-Multiplex Assays for Identification of the Herpotrichiellaceae Family and Agents Causing Chromoblastomycosis.

J Fungi (Basel)

August 2024

Laboratório de Micoses Superficiais e Sistêmicas, Seção de Bacteriologia e Micologia, Instituto Evandro Chagas, Ananindeua 67030-000, Brazil.

Article Synopsis
  • The Herpotrichiellaceae family consists of pathogenic fungi linked to diseases like chromoblastomycosis and phaeohyphomycosis, which present complex clinical symptoms and are found globally.
  • Identifying these fungi is difficult due to subjective morphological methods, leading researchers to rely on molecular techniques, particularly genetic sequencing of ribosomal DNA.
  • This study developed optimized PCR-Multiplex methodologies to improve the identification of these fungi, aiming to enhance infection management and provide more accurate epidemiological data.
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Article Synopsis
  • A 70-year-old woman had a single wart-like growth on her leg and painful sores in her mouth.
  • Doctors considered possible conditions like lichen simplex chronicus and chromoblastomycosis before diagnosing her with pemphigus vegetans (PVeg).
  • This case emphasizes the need to include PVeg in diagnoses for unusual skin growths, even when they appear in unexpected areas of the body.
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Article Synopsis
  • Deep-seated dermatomycosis is a rare fungal infection often linked to trauma and a weakened immune system, as seen in a 92-year-old Japanese man with a respiratory condition.
  • The patient developed distinct skin lesions and several abscesses caused by two different fungi, Exophiala xenobiotica and Scedosporium apiospermum, with severe cellular immunodeficiency indicated by low immune response tests.
  • Despite antifungal treatment, he ultimately died from bacterial pneumonia, highlighting how corticosteroids can impair immune function and worsen fungal infections.
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Article Synopsis
  • Chromoblastomycosis (CBM) is a chronic fungal infection affecting the skin and subcutaneous tissues, more common in developing countries than in the U.S.
  • A case study of a 75-year-old man who underwent a lung transplant revealed a painful lesion diagnosed as CBM, emphasizing the risk of such infections post-transplant.
  • The similarities in symptoms between CBM and cutaneous squamous cell carcinoma can lead to misdiagnosis, highlighting the importance of accurate evaluation in immunocompromised patients.
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Article Synopsis
  • * A case study highlights a 46-year-old woman with chromoblastomycosis, confirming the diagnosis through skin examinations and fungal cultures, while also revealing co-infestation by fly larvae.
  • * The patient was successfully treated with voriconazole and terbinafine, highlighting the need for awareness and understanding of chromoblastomycosis in occupationally exposed individuals in affected regions.
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Calcineurin activity in Fonsecaea pedrosoi: tacrolimus and cyclosporine A inhibited conidia growth, filamentation and showed synergism with itraconazole.

Braz J Microbiol

July 2024

Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos (LTBBF), Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, 21040-900, Brazil.

Article Synopsis
  • * The researchers discovered calcineurin activity in F. pedrosoi and found it can be inhibited by drugs like FK506 and CsA, which led to cell death and visible changes in the fungal structure.
  • * FK506 was the most effective treatment, with a lower required concentration to inhibit growth compared to CsA, and both drugs showed a synergistic effect when combined with itraconazole, highlighting calcineurin as a potential antifungal target.
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Article Synopsis
  • Chromoblastomycosis (CBM) is a chronic fungal skin infection caused mainly by dematiaceous fungi in tropical and subtropical regions, leading to plaques and scarring after healing.
  • Diagnosis can be enhanced with traditional methods like microscopy and culture, along with advanced techniques like dermatoscopy and reflectance confocal microscopy.
  • A case study from Guangdong shows successful management of CBM using a combination of itraconazole, terbinafine, and imiquimod, emphasizing new treatment strategies for this difficult condition.
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Potassium iodide enhances the killing effect of methylene blue mediated photodynamic therapy against F. monophora.

Photodiagnosis Photodyn Ther

August 2024

Guangdong Clinical College of Dermatology, Anhui Medical University, Hefei, China; Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Article Synopsis
  • Chromoblastomycosis (CMB) is a tough fungal skin infection with few treatment options and high relapse rates, highlighting the need for new therapies.
  • The study explored the effectiveness of a combined treatment using potassium iodide (KI) and Methylene Blue (MB) with light therapy to combat the fungus Fonsecaea monophora, both in lab experiments and in mice.
  • Results showed that KI improved the effectiveness of MB-mediated light therapy, producing more harmful agents against the fungus and suggesting this combination could be a promising therapy for CMB.
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Misleading subcutaneous mycosis: a case report of subsequent clinical mycetoma-like and histological chromoblastomycosis-like lesions.

Rev Inst Med Trop Sao Paulo

June 2024

Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Dermatologia, Campinas, São Paulo, Brazil.

Article Synopsis
  • * A rare case is reported involving an immunocompromised patient with two types of fungal infections: mycetoma-like hyalohyphomycosis on the foot from Colletotrichum gloeosporioides and cutaneous phaeohyphomycosis on the forearm from Exophiala oligosperma.
  • * The case highlights that certain fungal infections can mimic more common conditions, and muriform cells identified in skin examinations do not exclusively indicate chromoblastomycosis, as seen in this patient's forearm lesion.
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Dermatologic Fungal Neglected Tropical Diseases-Part I. Epidemiology and Clinical Features.

J Am Acad Dermatol

June 2024

Weill Cornell Medicine, Department of Dermatology, New York, NY. Electronic address:

Article Synopsis
  • * These infections are significant as they cause morbidity and stigma, and their occurrence may rise due to climate change and increased global travel.
  • * U.S. dermatologists are crucial for early detection and treatment of these conditions, which can reduce complications and improve patient outcomes.
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Dermatologic Fungal Neglected Tropical Diseases-Part II. Management and Morbidity.

J Am Acad Dermatol

June 2024

Weill Cornell Medicine, Department of Dermatology, New York, NY. Electronic address:

Article Synopsis
  • * These diseases are linked to poverty and immunosuppression, particularly in the U.S. due to global migration, and have serious morbidity effects like disfigurement, disability, and mental health issues.
  • * Effective management is challenging with low cure rates, highlighting the important role of dermatologists in early diagnosis and treatment to enhance patient outcomes.
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