3,210 results match your criteria: "Christchurch School of Medicine & Health Sciences. derelie.richards@chmeds.ac.nz[Affiliation]"
Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds.
JAMA Netw Open
October 2024
Department of Neurology, Medical University of Graz, Graz, Austria.
Article Synopsis
- Cerebral small vessel disease (SVD) can lead to various cerebrovascular issues, but research on sex differences in SVD is limited.
- This study analyzed data from over 20,000 patients with acute ischemic stroke to examine whether the presence and severity of cerebral microbleeds (CMB) and other SVD markers differ between males and females.
- Results showed that males had more frequent CMB while females had fewer lacunes but higher severe white matter hyperintensities, indicating distinct SVD characteristics based on sex.
Cardiac troponin elevation and mortality in takotsubo syndrome: New insights from the international takotsubo registry.
Eur J Clin Invest
December 2024
Department of Cardiology and Internal Medicine B, University Medicine, Greifswald, Germany.
Article Synopsis
- The study investigates the significance of cardiac troponin (cTn) levels in predicting mortality in patients with Takotsubo syndrome (TTS), analyzing data from the International Takotsubo Registry.
- It identifies that a cTn increase greater than 28.8 times the upper reference limit signals clinically relevant myocardial injury, correlating with a higher risk of mortality over 5 years (adjusted HR 1.58).
- The findings enhance understanding of patient risk profiles in TTS, emphasizing the need for increased monitoring and follow-up for those with significant troponin elevations.
Bariatric surgery outcomes in patients on chronic kidney replacement therapy in Australia and New Zealand.
Br J Surg
October 2024
Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.
Early Childhood Concussion.
Pediatrics
November 2024
Kennedy Krieger Institute and Departments of Physical Medicine & Rehabilitation and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Article Synopsis
- Early childhood is a period where children have underdeveloped motor and cognitive skills, increasing their risk for traumatic injuries, including concussions.
- There is limited understanding of concussions in young children compared to older age groups, prompting a need for more comprehensive research and knowledge.
- The review offers insights into the symptoms, diagnosis, and management of concussions in early childhood, while emphasizing the need for developmentally suitable methods to enhance detection and treatment.
Experiences of adolescents and young adults with type 1 diabetes and chronically elevated glucose levels following the transition from multiple daily injections to advanced hybrid closed-loop: A qualitative study.
Diabet Med
January 2025
Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Article Synopsis
- The study aimed to explore the experiences of adolescents and young adults (ages 13-25) with chronic high glucose levels who switched from multiple daily injections (MDI) to advanced hybrid closed-loop (AHCL) therapy.
- Researchers conducted semi-structured interviews with 14 participants after three months on the AHCL, identifying three key themes: improved glucose levels enhanced overall health perceptions, AHCL features supported self-management, and insulin delivery automation reduced care burden.
- The transition to AHCL therapy resulted in positive impacts on physical, mental, and social well-being, although some participants experienced transient pseudo-hypoglycaemia, highlighting the need for individualized support to facilitate uptake.
Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation.
JAMA Neurol
September 2024
Department of Cardiology, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands.
Article Synopsis
- Patients with a heart condition called atrial fibrillation (AF) who have strokes can still be at very high risk of having more strokes, even when taking medication to prevent them.
- Left atrial appendage occlusion (LAAO) is a special procedure aimed at helping these patients avoid future strokes.
- A study compared two groups – one that had LAAO and one that only continued their usual medication – and found that there was still a risk of strokes in both groups over a two-year period.
Targeted K-Edge Nanoprobes From Praseodymium and Hafnium for Ratiometric Tracking of Dual Biomarkers using Spectral Photon Counting CT.
Adv Sci (Weinh)
December 2024
Huck Institutes of the Life Sciences, Department(s) of Biomedical Engineering, Nuclear Engineering, Materials Science and Engineering, The Pennsylvania State University, 101 Huck Life Sciences Building, University Park PA, 16802, USA.
Article Synopsis
- Scientists created tiny metal probes called nanoprobes to help see and study important parts of cartilage tissue in our bodies.
- These nanoprobes are made from two different metals, praseodymium and hafnium, which can be identified separately using special imaging technology.
- This new method can help track diseases like osteoarthritis by showing two important markers at the same time.
The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors.
J Diabetes Sci Technol
November 2024
University of California San Francisco, San Francisco, CA, USA.
Article Synopsis
- An error grid is a tool that helps compare glucose levels measured by devices to see if they are correct and to identify any risks.
- Experts created a new error grid called the DTS Error Grid that works for both blood glucose monitors (BGMs) and continuous glucose monitors (CGMs), organizing accuracy into five risk zones.
- The results showed that the DTS Error Grid provides a clearer picture of how accurate these devices are and includes a separate matrix to evaluate how well CGMs track glucose trends over time.
The International Climate Psychology Collaboration: Climate change-related data collected from 63 countries.
Sci Data
October 2024
Department of Psychology, New York University; New York University, New York, 10003, USA.
Article Synopsis
- Scientists did a big survey with over 59,000 people from 63 countries to understand how people think about climate change!
- They tested different ways to encourage people to believe in climate change and support actions to help the environment!
- The study includes lots of information and data that can help others learn more about what influences people's actions on climate change around the world!
Article Synopsis
- * Conducted on 122 patients with moderate to severe aortic stenosis, the research identified specific circulating proteins that correlate with higher risks of heart failure, severe symptoms, and mortality.
- * Key proteins linked to inflammation and immune responses were significantly associated with worse outcomes, particularly in patients showing reduced heart strain, suggesting new avenues for assessing patient risk beyond standard imaging methods.
Post-hoc analysis of two gout remission definitions in a two-year randomized controlled trial of nurse-led versus usual gout care.
Semin Arthritis Rheum
December 2024
Department of Medicine, The Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Article Synopsis
- The study aimed to compare two definitions of gout remission in a clinical trial focused on nurse-led care versus usual care.
- Data from a randomized trial with 517 participants showed that nurse-led care significantly improved the odds of achieving remission, particularly when using a simplified definition.
- The simplified remission definition not only identified more participants in remission over time but also correlated with better gout management outcomes, proving to be a valid and practical alternative.
Robotic and Laparoscopic Adrenalectomy for Pheochromocytoma: An International Multicenter Study.
Eur Urol Focus
September 2024
Department of Hepatopancreatobiliary and Liver Transplant Surgery, Queen Elizabeth Hospital, Birmingham, UK.
Background And Objective: Robotic adrenalectomy (RA) has attracted interest as an alternative to laparoscopic adrenalectomy (LA) for patients with pheochromocytoma, although its beneficial effects are uncertain. Our aim was to compare RA and LA outcomes for these patients.
Methods: Data for patients who underwent RA or LA for pheochromocytoma in 46 international centers between 2012 and 2022 were reviewed.
Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma.
HPB (Oxford)
December 2024
Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands; GROW - School for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229, ER, Maastricht, The Netherlands; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address:
Background: Major hepatectomy in perihilar cholangiocarcinoma (pCCA) patients with a small future liver remnant (FLR) risks posthepatectomy liver failure (PHLF). This study examines combined portal and hepatic vein embolisation (PVE/HVE) to increase preoperative FLR volume and potentially decrease PHLF rates.
Methods: In this retrospective, multicentre, observational study, data was collected from centres affiliated with the DRAGON Trials Collaborative and the EuroLVD registry.
Global burden of cardiovascular diseases: projections from 2025 to 2050.
Eur J Prev Cardiol
September 2024
Yong Loo Lin School of Medicines, National University Singapore, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
Article Synopsis
- The study aims to project cardiovascular disease (CVD) mortality trends and risk factors from 2025 to 2050 to aid healthcare planning.
- Using historical data and Poisson regression, projections indicate a significant increase in CVD prevalence (90%), crude mortality (73.4%), and DALYs (54.7%), with ischaemic heart disease and high blood pressure as major contributors.
- Despite a stable age-standardized CVD prevalence, the study underscores a concerning rise in crude mortality due to an aging population, prompting the need for effective healthcare strategies.
Ethnic Differences in the Safety and Efficacy of Tenecteplase Versus Alteplase for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.
J Stroke
September 2024
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Background And Purpose: Tenecteplase is a thrombolytic agent with pharmacological advantages over alteplase and has been shown to be noninferior to alteplase for acute ischemic stroke in randomized trials. However, evidence pertaining to the safety and efficacy of tenecteplase in patients from different ethnic groups is lacking. The aim of this systematic review and metaanalysis was to investigate ethnicity-specific differences in the safety and efficacy of tenecteplase versus alteplase in patients with acute ischemic stroke.
View Article and Find Full Text PDFThe relative associations of aortic and carotid artery stiffness with CeVD and cognition.
J Cereb Blood Flow Metab
September 2024
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Article Synopsis
- A study involving 272 memory clinic participants aimed to explore the relationship between stiffness in aortic and carotid arteries and various aspects of cerebrovascular disease, cognition, and dementia subtypes.
- Researchers used applanation tonometry and carotid ultrasonography to measure artery stiffness and assessed cognitive function through tests like MMSE and MoCA.
- Results indicated that carotid artery stiffness was significantly linked to markers of cerebrovascular disease and cognitive impairment, showing a stronger impact than aortic stiffness on these health issues.
Frequent hemodialysis versus standard hemodialysis for people with kidney failure: Systematic review and meta-analysis of randomized controlled trials.
PLoS One
September 2024
Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia.
Article Synopsis
- Frequent hemodialysis (more than three times a week) may lower mortality and improve quality of life for kidney failure patients, but the evidence is not clear.
- A systematic review of available studies found only seven eligible trials with a total of 518 participants, indicating limited data on the health effects of frequent hemodialysis.
- The analysis suggested a possibly lower risk of death with frequent hemodialysis, but results were uncertain, and important outcomes like cardiovascular events and patient-reported well-being were largely missing.
Neck or Shoulder? Establishing Consensus for Spine Screening in Patients with Shoulder Pain: an International Modified Delphi Study.
Phys Ther
September 2024
Physiotherapy in Motion, Multi-Speciality Research Group (PTinMOTION), Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Valencia, Spain.
Objective: There is no established consensus for screening the spine in patients with shoulder pain. The aim of this study was to explore the role of the spine in shoulder pain and generate a set of recommendations for assessing the potential involvement of the spine in patients with shoulder pain.
Methods: A modified Delphi study was conducted through use of an international shoulder physical therapist's expert panel.
Two-Year Outcomes of Prostatic Artery Embolization for Symptomatic Benign Prostatic Hyperplasia: An International, Multicenter, Prospective Study.
Cardiovasc Intervent Radiol
November 2024
University Department of Radiology, Royal Berkshire Hospital, Reading, UK.
Purpose: To describe clinical outcomes among patients with benign prostatic hyperplasia (BPH) 24 months following prostatic artery embolization (PAE).
Materials And Methods: This was an international, multicenter, prospective trial of males with BPH with lower urinary tract symptoms (LUTS) or acute urinary retention (AUR) treated with PAE. The primary outcome was the 12 month change in the International Prostate Symptom Score (IPSS) for patients referred for bothersome LUTS, or urinary catheter independence for patients treated for AUR.
An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality.
bioRxiv
August 2024
Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
To understand how aging affects functional decline and increases disease risk, it is necessary to develop accurate and reliable measures of how fast a person is aging. Epigenetic clocks measure aging but require DNA methylation data, which many studies lack. Using data from the Dunedin Study, we introduce an accurate and reliable measure for the rate of longitudinal aging derived from cross-sectional brain MRI: the Dunedin Pace of Aging Calculated from NeuroImaging or DunedinPACNI.
View Article and Find Full Text PDFFinerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.
N Engl J Med
October 2024
From the Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston (S.D.S., M.V., B.C., A.S.D.); British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow (J.J.V.M., P.S.J., A.D.H., M.C.P.), and Bayer, Reading (J.L.-F.) - both in the United Kingdom; National Heart Centre Singapore and Duke-National University of Singapore, Singapore (C.S.P.L.); University of Michigan School of Medicine, Ann Arbor (B.P.); University of Milano-Bicocca and Papa Giovanni XXIII Hospital, Bergamo (M. Senni), and the Department of Cardiology, University of Brescia, and ASST "Spedali Civili" Hospital, Brescia (S.N.) - all in Italy; Northwestern University Feinberg School of Medicine, Chicago (S.J.S.); University Medical Center Groningen, Groningen (A.A.V.), the Department of Cardiology, Hospital Group Twente, Almelo (G.C.M.L.), and Bayer, Hoofddorp (I.G.) - all in the Netherlands; Université de Lorraine, INSERM Clinical Investigation Centre, Centre Hospitalier Universitaire, Nancy, France (F.Z.); University of Malaya, Kuala Lumpur, Malaysia (I.Z.A.); Centro de Estudios Clínicos de Querétaro, Santiago de Querétaro (M.A.A.-G.), and Hospital Cardiologico Aguascalientes, Aguascalientes (G.L.-E.) - both in Mexico; Cardiology Research Department, Royal Brisbane and Women's Hospital, University of Queensland, Brisbane, Australia (J.J.A.); the Department of Cardiology and Angiology, Hannover Medical School, Hannover (J.B.), and Bayer, Wuppertal (P.K.) - both in Germany; Beijing Anzhen Hospital, Capital Medical University, Beijing (M.C.-S.); General Clinical Research Center and Division of Cardiology, Taipei Veterans General Hospital, and National Yang Ming Chiao Tung University, Taipei, Taiwan (C.-E.C.); Emergency Institute for Cardiovascular Diseases "Prof. Dr. C.C. Iliescu," University of Medicine Carol Davila, Bucharest, Romania (O.C.); Clinical Cardiology, Heart Failure and Research, Max Super Specialty Hospital, New Delhi, India (V.C.); the Department of Cardiology, Bellvitge University Hospital, and Bellvitge Biomedical Research Institute, Centro de Investigación Biomédica En Red Enfermedades Cardiovasculares, University of Barcelona, L'Hospitalet de Llobregat, Barcelona (J.C.-C.); the Department of Cardiology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens (G.F.); the Department of Internal Medicine, Hospital São Francisco Xavier, and NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.); the Department of Coronary Disease and Heart Failure, Jagiellonian University Medical College, Krakow, Poland (G.G.); the Heart Institute, Kaplan Medical Center, Rehovot, and Hebrew University, Jerusalem - both in Israel (S.G.); the Faculty of Medicine, Comenius University, Bratislava, Slovakia (E.G.); the Division of Cardiology, Severance Hospital, and Yonsei University Health System, Seoul, South Korea (S.K.); the Department of Noninvasive Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); St. Luke's Mid America Heart Institute, University of Missouri-Kansas City, Kansas City (M.N.K.); Latvian Center of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia (G.L.); Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong, Hong Kong (A.P.-W.L.); University Clinic of Lomonosov Moscow State University, Moscow (V. Mareev); Universidad Nacional de Córdoba, Córdoba, Argentina (F.A.M.); the Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (V. Melenovský); the Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Centro Cardiovascular Colombiano, Clínica Santa María, Medellin, Colombia (C.I.S.); Cardiovascular Division, Instituto de Pesquisa Clínica de Campinas, Campinas (J.F.K.S.), and Bayer, São Paulo (F.A.) - both in Brazil; Kawaguchi Cardiovascular and Respiratory Hospital, Saitama, Japan (N.S.); the Department of Cardiology, Herlev-Gentofte University Hospital, Hellerup, Denmark (M. Schou); the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore (K.S.); Christchurch Heart Institute, Department of Medicine, University of Otago, Christchurch, New Zealand (R.T.); Women's College Hospital and Peter Munk Cardiac Centre, Toronto General Hospital (J.A.U.), University of Toronto (J.A.U., S.V.), and the Division of Cardiac Surgery, St. Michael's Hospital (S.V.), Toronto, and the Section of Cardiology, Max Rady College of Medicine, University of Manitoba, Winnipeg (S.Z.) - both in Canada; Heart Centre, Turku University Hospital, Turku, Finland (H.U.); the Department of Medicine, University of Minnesota, and Minneapolis VA Health Care System, Minneapolis (O.V.); the Department of Internal Medicine, Division of Cardiology, Medical University of Graz, Graz, Austria (D.L.); National Scientific Center, Strazhesko Institute of Cardiology, National Academy of Medical Sciences, Kyiv, Ukraine (L.V.); Dokuz Eylul University Medical Faculty, Cardiology Department, Izmir, Turkey (M.B.Y.); and Bayer, Whippany, NJ (P.V.).
Article Synopsis
- Steroidal mineralocorticoid receptor antagonists help patients with heart failure and reduced ejection fraction, but their effectiveness in those with mildly reduced or preserved ejection fraction is unclear, indicating a need for further research on finerenone.
- In a double-blind study, patients with heart failure (ejection fraction 40% or greater) were assigned to receive either finerenone or a placebo to assess its impact on heart failure events and cardiovascular death.
- Results showed that finerenone led to fewer worsening heart failure events and a lower overall rate of primary outcome events compared to placebo, although it also carried a higher risk of hyperkalemia.
The prevalence and clinical features of leflunomide-associated peripheral neuropathy in patients with rheumatic disease in a New Zealand cohort.
Int J Rheum Dis
September 2024
Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Objective: To identify the prevalence and clinical features of leflunomide-associated peripheral neuropathy in patients with rheumatic disease over a 42-month observational period between January 1, 2016 and June 30, 2019.
Methods: A retrospective observational study was conducted using regional prescription data identifying all patients treated with leflunomide for rheumatic diseases in the Southern District Health Board of New Zealand. Medical records were used to identify patients who developed peripheral neuropathy while receiving treatment with leflunomide.
Temporal Trends in Takotsubo Syndrome: Results From the International Takotsubo Registry.
J Am Coll Cardiol
September 2024
Department of Cardiology and Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy.
Article Synopsis
- The study investigated changes in demographics, risk factors, clinical presentations, and outcomes of takotsubo syndrome (TTS) patients from 2004 to 2021, using data from the InterTAK registry.
- Over the years, the proportion of male patients increased, and there was a rise in cases of midventricular TTS as well as significant growth in the incidence of physical triggers.
- There was also a notable increase in 60-day mortality rates, although no significant change in 1-year mortality when excluding early deaths was observed, indicating a complex evolution of TTS and its management in recent years.
Use of a decision support tool and quick start onboarding tool in individuals with type 1 diabetes using advanced automated insulin delivery: a single-arm multi-phase intervention study.
BMC Endocr Disord
August 2024
Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, 201 Great King St, Dunedin, Otago, 9016, New Zealand.
Background: Multiple clinician adjustable parameters impact upon glycemia in people with type 1 diabetes (T1D) using Medtronic Mini Med 780G (MM780G) AHCL. These include glucose targets, carbohydrate ratios (CR), and active insulin time (AIT). Algorithm-based decision support advising upon potential settings adjustments may enhance clinical decision-making.
View Article and Find Full Text PDFClinical research in endometrial cancer: consensus recommendations from the Gynecologic Cancer InterGroup.
Lancet Oncol
September 2024
Kaiser Permanente Northern California, San Francisco, CA, USA.
Article Synopsis
- The GCIG Endometrial Cancer Consensus Conference was held in Incheon, South Korea, aimed at creating consensus statements to improve future clinical trials in endometrial cancer.
- Representatives from 33 member groups developed 18 statements across four key topics, focusing on treatment strategies and trial methodologies, including consideration for low-resource settings.
- For the first time, the conference included patient advocates and early-career investigators, resulting in a high consensus rate on the statements, reinforcing progress in global clinical research for endometrial cancer.