Selective dual-mode detection of reactive oxygen species and metal ions by chemodosimetric chelation pathways: fluorescence 'turn-on' with OCl and Zn/Mn, employing theoretical, practical, and bioimaging applications.

An indole-coupled diaminomaleonitrile-based fluorescent chemosensor IMA has been designed and developed for the selective detection of ROS (OCl) and metal ions Zn and Mn chemodosimetric and chelation pathways respectively. The selective sensing of OCl is induced by a method of oxidatively cleaving of the imine bond of IMA, forming free indole aldehyde, which results in a 21-fold enhancement of fluorescence at 521 nm, with a detection limit of 2.8 µM.

A rapid investigation of near-infrared (NIR) fluorescent switch-on probes for detection and in cellulo tracking of G-quadruplex and double-stranded DNA.

This review provides a comprehensive overview of the recent advancements in Near Infrared (NIR) fluorescence switch-on probes designed for the detection and in cellulo tracking of G-quadruplex and double-stranded DNA (dsDNA). G-quadruplexes, non-canonical DNA structures, play pivotal roles in regulating various biological processes, making them critical targets for therapeutic and diagnostic applications. The unique properties of NIR fluorescence probes, such as deep tissue penetration, minimal photodamage, and low autofluorescence background, offer significant advantages for bioimaging.