1 results match your criteria: "Chris Hani-Baragwanath Hospital and the National Health Laboratory Service[Affiliation]"
Endotoxin-independent white cell cytokine production in haemodynamically stable patients with idiopathic dilated cardiomyopathy.
Cardiovasc J S Afr
April 2006
Cardiovascular Pathophysiology Laboratory, School of Physiology, University of the Witwatersrand, Chris Hani-Baragwanath Hospital and the National Health Laboratory Service, Johannesburg, South Africa.
Introduction: In heart failure, increased circulating white cell tumour necrosis factor-alpha production could be attributed to elevated plasma endotoxin concentrations or an increase in white cell sensitivity to endotoxin.
Aims: To ascertain whether, in patients with IDC, circulating white cell TNF-alpha production is also mediated through endotoxin-independent mechanisms.
Methods: Whole blood production of TNF-alpha, both with and without the presence of an endotoxin stimulus, was evaluated in 89 controls and in 60 patients with IDC in New York Heart Association functional class I, II or III heart failure and without evidence of oedema, reduced peripheral perfusion or elevated plasma endotoxin concentrations.