Computational insights into potent USP5 inhibitors based on multistep virtual screening and molecular dynamics simulation.

USP5 is widely distributed in various malignant tumors and can regulate the stability and promoting tumor progression of many tumor-related proteins. However, there is still a lack of highly active USP5 inhibitors. Therefore, effective inhibitors were screened in the TCMIO database in this study.

Mixed Lineage Leukemia 1 Promoted Neuron Apoptosis in Ischemic Penumbra Regulating ASK-1/TNF-α Complex.

Neuron apoptosis in ischemic penumbra was proved to be involved in ischemic stroke (IS) development and contributed to the poor prognosis of IS. Recent studies showed that aberrant trimethylation of histone H3 lysine 4 (H3K4me3) level was associated with cell apoptosis. This study aimed to explore the underlying mechanism of neuron apoptosis in ischemic penumbra histone methyltransferase (HMT) mixed lineage leukemia 1 (MLL1) mediated epigenetic pathway.